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Full-Text Articles in Medicine and Health Sciences
Randomized, Double-Blind, Placebo-Controlled Trial Of The Effect Of Vitamin D3 On The Interferon Signature In Patients With Systemic Lupus Erythematosus, C. Aranow, D. L. Kamen, M. Dall'era, E. M. Massarotti, M. C. Mackay, F. Koumpouras, A. Coca, W. W. Chatham, M. E. Clowse, L. G. Criscione-Schreiber, S. Callahan, E. A. Goldmuntz, L. Keyes-Elstein, M. Oswald, P. K. Gregersen, B. Diamond
Randomized, Double-Blind, Placebo-Controlled Trial Of The Effect Of Vitamin D3 On The Interferon Signature In Patients With Systemic Lupus Erythematosus, C. Aranow, D. L. Kamen, M. Dall'era, E. M. Massarotti, M. C. Mackay, F. Koumpouras, A. Coca, W. W. Chatham, M. E. Clowse, L. G. Criscione-Schreiber, S. Callahan, E. A. Goldmuntz, L. Keyes-Elstein, M. Oswald, P. K. Gregersen, B. Diamond
Journal Articles
OBJECTIVE: Vitamin D modulates the immune response and blocks induction of an interferon (IFN) signature by systemic lupus erythematosus (SLE) sera. This study was undertaken to investigate the effects of vitamin D supplementation on the IFN signature in patients with SLE. METHODS: SLE patients (n = 57) with stable, inactive disease, a serum 25-hydroxyvitamin D (25[OH]D) level/=30 ng/ml) was not observed in any of the patients who were receiving placebo, while repletion was observed in 16 of 33 patients receiving vitamin D3 . The percentage of patients with an IFN signature response did not differ among the treatment groups. Moreover, …