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- Antispasmodic (3)
- Antidiarrheal (2)
- ALK alteration (1)
- ATP-dependent K+ channel activation (1)
- Adiantum capillus-veneris (1)
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- African giant rat (1)
- Analgesia (1)
- Antidiarrhoeal (1)
- Antisecretory (1)
- Astrocyte morphologies (1)
- Bone marrow aspiration (1)
- Bone marrow biopsy (BMBx) (1)
- Breast cancers (1)
- Ca++ antagonist (1)
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- Cell viability (1)
- Chamomile (1)
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- FoxM1 (1)
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- Invasion (1)
- K+ channel activation (1)
- K+ channels activation (1)
- Mammalian central nervous system (1)
- Non-pharmacological methods (1)
- P. bistorta (1)
- Pain control (1)
- Pharmacological agents (1)
Articles 1 - 8 of 8
Full-Text Articles in Medicine and Health Sciences
Methods Of Reducing Pain During Bone Marrow Biopsy: A Narrative Review, Mohammad Faizan Zahid
Methods Of Reducing Pain During Bone Marrow Biopsy: A Narrative Review, Mohammad Faizan Zahid
Medical College Documents
Bone marrow examination plays a crucial role in the diagnosis and management of various hematological and systemic diseases. Even though the procedure has been carried out for decades, it remains an extremely painful and uncomfortable experience for a majority of patients. This paper reviews the different strategies used to provide analgesia and summarizes the advantages and drawbacks of one strategy over the other. A literature review was carried out addressing the different approaches to providing pain relief during bone marrow aspiration and biopsy. Several different methods, procedure modifications and protocols are employed at various centers but pain control and analgesia …
Astrocyte Morphology, Heterogeneity, And Density In The Developing African Giant Rat (Cricetomys Gambianus), Matthew A. Olude, Oluwaseun A. Mustapha, Oluwatunde A. Aderounmu, James O. Olopade, Amadi O. Ihunwo
Astrocyte Morphology, Heterogeneity, And Density In The Developing African Giant Rat (Cricetomys Gambianus), Matthew A. Olude, Oluwaseun A. Mustapha, Oluwatunde A. Aderounmu, James O. Olopade, Amadi O. Ihunwo
Brain and Mind Institute
Astrocyte morphologies and heterogeneity were described in male African giant rats (AGR; Cricetomys gambianus, Waterhouse) across three age groups (five neonates, five juveniles, and five adults) using Silver impregnation method and immunohistochemistry against glial fibrillary acidic protein. Immunopositive cell signaling, cell size and population were least in neonates, followed by adults and juveniles, respectively. In neonates, astrocyte processes were mostly detected within the glia limitans of the mid and hind brain; their cell bodies measuring 32 ± 4.8 μm in diameter against 91 ± 5.4 μm and 75 ± 1.9 μm in juveniles and adults, respectively. Astrocyte heterogeneity in …
Antidiarrheal And Antispasmodic Activities Of Polygonum Bistorta Rhizomes Are Mediated Predominantly Through K+ Channels Activation, Muhammad Zeeshan Ali, Khalid Hussain Janbaz, Hassan Mehmood, Anwar Hassan Gilani
Antidiarrheal And Antispasmodic Activities Of Polygonum Bistorta Rhizomes Are Mediated Predominantly Through K+ Channels Activation, Muhammad Zeeshan Ali, Khalid Hussain Janbaz, Hassan Mehmood, Anwar Hassan Gilani
Department of Biological & Biomedical Sciences
Polygonum bistorta is a popular medicinal herb used to treat diarrhea. This study provides pharmacological basis to its folk use in diarrhea using in vivo and in vitro assays. Administration of P. bistorta rhizomes extract to mice offered protection against castor oil-induced diarrhea at 300-1,000 mg/kg and was found safe up to the dose of 5 g/kg. In isolated rabbit jejunum, the extract caused a dose-dependent relaxation of spontaneous and low K+ (25 mM)-induced contractions with weak effect against high K+ (80 mM). In tissues pretreated with glibenclamide or tetraethylammonium chloride (TEA), the relaxant effect of the extract …
Antidiarrhoeal, Antisecretory And Antispasmodic Activities Of Matricaria Chamomilla Are Mediated Predominantly Through K+-Channels Activation, Hassan Mehmood, Siraj Munir, Uzair Ali Khalid, Mudassir Asrar, Anwarul Hassan Gilani
Antidiarrhoeal, Antisecretory And Antispasmodic Activities Of Matricaria Chamomilla Are Mediated Predominantly Through K+-Channels Activation, Hassan Mehmood, Siraj Munir, Uzair Ali Khalid, Mudassir Asrar, Anwarul Hassan Gilani
Department of Biological & Biomedical Sciences
Background: Matricaria chamomilla commonly known as “Chamomile” (Asteraceae) is a popular medicinal herb widely used in indigenous system of medicine for a variety of ailments. However, there is no detailed study available showing its effectiveness in hyperactive gut disorders like, abdominal colic and diarrhoea. This study was designed to determine the pharmacological basis for the folkloric use of Matricaria chamomilla in diarrhoea.
Methods: The crude aqueous-methanolic extract of Matricaria chamomilla (Mc.Cr) was studied for its protective effect in mice against castor oil-induced diarrhoea and intestinal fluid accumulation. The isolated rabbit jejunum was selected for the in-vitro experiments using tissue bath …
Antidiarrheal And Antispasmodic Activities Of Adiantum Capillus-Veneris Are Predominantly Mediated Through Atp-Dependent K+ Channels Activation, Khalid Hussain Janbaz, Waseem Hassan, Hassan Mehmood, Anwar Hassan Gilani
Antidiarrheal And Antispasmodic Activities Of Adiantum Capillus-Veneris Are Predominantly Mediated Through Atp-Dependent K+ Channels Activation, Khalid Hussain Janbaz, Waseem Hassan, Hassan Mehmood, Anwar Hassan Gilani
Department of Biological & Biomedical Sciences
The study was tempted to explore the scientific basis for the medicinal use of Adiantum capillus-veneris L. in diarrhea using the in vivo and in vitro assays. The crude extract of dried leaves of A. capillus-veneris exhibited antidiarrheal effect against castor oil-induced diarrhea in mice at 300 and 500 mg/kg, similar to the effect loperamide. It was also found safe up to administered dose of 7 g/kg in mice. In isolated rabbit jejunum, extract of A. capillus-veneris showed a concentration-dependent relaxation of spontaneous and low K+ (25 mM)-induced contractions and had weak inhibitory effect on high K+ (80 …
Alk Alteration Is A Frequent Event In Aggressive Breast Cancers, Abdul K. Siraj, Shaham Beg, Zeenath Jehan, Sarita Prabhakaran, Maqbool Ahmed, Azhar Hussain, Fouad Al-Dayel, Asma Tulbah, Dahish Ajarim, Khawla S. Al-Kuraya
Alk Alteration Is A Frequent Event In Aggressive Breast Cancers, Abdul K. Siraj, Shaham Beg, Zeenath Jehan, Sarita Prabhakaran, Maqbool Ahmed, Azhar Hussain, Fouad Al-Dayel, Asma Tulbah, Dahish Ajarim, Khawla S. Al-Kuraya
Centre for Regenerative Medicine & Stem Cell Research
Introduction: Breast cancer is the most common female malignancy worldwide and, despite improvements in treatment modalities, there are increased chances of recurrence and metastasis in a substantial number of cases and it remains one of the major causes of mortality among female cancer patients. Anaplastic lymphoma kinase (ALK) gene has been found to be altered in several solid and hematologic tumors. We aimed to comprehensively study the prevalence of ALK expression, and changes in copy number and translocation in a large cohort of breast cancer cases in a Middle Eastern population.
Methods: ALK protein expression was investigated by immunohistochemistry and …
R990g Polymorphism Of Calcium Sensing Receptor Gene Is Associated With High Parathyroid Hormone Levels In Subjects With Vitamin D Deficiency: A Cross-Sectional Study, Hafsa Majid, Aysha Habib Khan, Tariq Moatter
R990g Polymorphism Of Calcium Sensing Receptor Gene Is Associated With High Parathyroid Hormone Levels In Subjects With Vitamin D Deficiency: A Cross-Sectional Study, Hafsa Majid, Aysha Habib Khan, Tariq Moatter
Department of Pathology and Laboratory Medicine
Single nucleotide polymorphisms (SNPs), R990G and A986S of the calcium sensing receptor (CaSR) gene, are shown to influence response of parathyroid hormone (PTH) in subjects with optimal vitamin D levels. This cross-sectional study was conducted in subjects with vitaminDdeficiency (VDD) to observe association’s betweenCaSR polymorphisms, plasma iPTH, and serumcalcium levels. Adult females (𝑛 = 140) with known VDD, intact parathyroid hormone (iPTH), and calcium levels were recruited for genotype analysis.The frequencies of the 986 alleles GG, GT, and TT were 68%, 25%, and 7%, respectively, whereas the frequencies of the 990 alleles AA, AG, and GG were 80%, 8.9%, and …
Co-Targeting Of Cyclooxygenase-2 And Foxm1 Is A Viable Strategy In Inducing Anticancer Effects In Colorectal Cancer Cells, Maqbool Ahmed, Azhar Hussain, Abdul K. Siraj, Shahab Uddin, Nasser Al-Sanea, Fouad Al-Dayel, Mohammed Al-Assiri, Shaham Beg, Khawla S. Al-Kuraya
Co-Targeting Of Cyclooxygenase-2 And Foxm1 Is A Viable Strategy In Inducing Anticancer Effects In Colorectal Cancer Cells, Maqbool Ahmed, Azhar Hussain, Abdul K. Siraj, Shahab Uddin, Nasser Al-Sanea, Fouad Al-Dayel, Mohammed Al-Assiri, Shaham Beg, Khawla S. Al-Kuraya
Centre for Regenerative Medicine & Stem Cell Research
Background: Cross-talk between deregulated signaling pathways in cancer cells causes uncontrolled growth and proliferation. These cancers cells become more aggressive and quickly develop resistance to therapy. Therefore targeting of these deregulated pathways simultaneously can result in efficient cell death of cancer cells. In this study we investigated co-expression of Cox-2 and FoxM1 in a cohort of colorectal carcinoma (CRC) samples and also examined whether inhibition of Cox-2 and FoxM1 simultaneously can lead to inhibition of cell viability and induction of apoptosis in colorectal cancer cell lines and in vivo xenograf
Methods: Protein expression of Cox-2 and FoxM1 was determined …