Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 2 of 2
Full-Text Articles in Medicine and Health Sciences
Kitchen 2.0: Investigation Of The Effect Of Ventilation On Indoor Air Quality, Kelli Marie Whelan
Kitchen 2.0: Investigation Of The Effect Of Ventilation On Indoor Air Quality, Kelli Marie Whelan
Dissertations, Master's Theses and Master's Reports
Even in today’s technology-filled world, nearly half of the global population still relies on some form of biomass to meet their daily energy requirement. Currently, improved combustion technologies (improved cookstoves) are the most common intervention to reduce fuel usage and to reduce human exposure to harmful products of incomplete combustion. This report explores an alternative option to cookstove replacement: ventilation as a low-cost, low-impact solution for health risk reduction.
Engineering Approaches For Suppressing Deleterious Host Responses To Medical Implants, Connor Mccarthy
Engineering Approaches For Suppressing Deleterious Host Responses To Medical Implants, Connor Mccarthy
Dissertations, Master's Theses and Master's Reports
Small diameter (< 6 mm) vascular grafts suffer from serious deleterious effects not encountered with their larger diameter relatives, leading to premature graft failure through restenosis. Platelet activation, inflammation, and smooth muscle cell proliferation are leading contributors to thrombosis and neointimal hyperplasia, both contributors to the progression of restenosis. It may be possible to suppress negative biological responses to vascular implants through the modification of surface properties and incorporation of drug release into blood contacting materials. In this work, bioengineering approaches are presented to improve the biocompatibility of small diameter vascular grafts.
We demonstrate a novel engineering approach for incorporating natural, decollagenized elastin matrices into PEU 1074A reinforced vascular grafts through spray-coating and electrospinning processes in a manner that retains elastin’s excellent blood contacting properties. A vascular construct with excellent mechanical and surgical handling properties demonstrating the suppression of neointimal hyperplasia is presented after 21 days in vivo.
Nitric oxide (NO) has been investigated over the past several decades due to its platelet, inflammation, and smooth muscle cell suppressing effects; and if appropriately delivered, could positively mediate the contributors to restenosis. Here, we characterize a novel macrocyclic NO …