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Hyperglycemia-Induced Diaphragm Weakness Is Mediated By Oxidative Stress, Leigh Ann Callahan, Gerald S. Supinski
Hyperglycemia-Induced Diaphragm Weakness Is Mediated By Oxidative Stress, Leigh Ann Callahan, Gerald S. Supinski
Internal Medicine Faculty Publications
INTRODUCTION: A major consequence of ICU-acquired weakness (ICUAW) is diaphragm weakness, which prolongs the duration of mechanical ventilation. Hyperglycemia (HG) is a risk factor for ICUAW. However, the mechanisms underlying HG-induced respiratory muscle weakness are not known. Excessive reactive oxygen species (ROS) injure multiple tissues during HG, but only one study suggests that excessive ROS generation may be linked to HG-induced diaphragm weakness. We hypothesized that HG-induced diaphragm dysfunction is mediated by excessive superoxide generation and that administration of a specific superoxide scavenger, polyethylene glycol superoxide dismutase (PEG-SOD), would ameliorate these effects.
METHODS: HG was induced in rats using streptozotocin …