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Articles 1 - 3 of 3
Full-Text Articles in Medicine and Health Sciences
Using Collagen Binding Poly(N-Isopropylacrylamide) Nanoparticles To Prevent Intravascular Platelet Adhesion And Activation, Anna E. Searle, Alyssa Panitch, James Mcmasters
Using Collagen Binding Poly(N-Isopropylacrylamide) Nanoparticles To Prevent Intravascular Platelet Adhesion And Activation, Anna E. Searle, Alyssa Panitch, James Mcmasters
The Summer Undergraduate Research Fellowship (SURF) Symposium
Balloon angioplasty, the most prevalent non-surgical treatment for Atherosclerosis, damages the endothelial layer of the artery, baring an underlying collagenous layer, which causes platelet adhesion and activation and eventual thrombosis and intimal hyperplasia. Previous work in our lab has used a collagen-binding peptidoglycan, dermatan-sulfate-SILY (DS-SILY), that has been shown to bind to type I collagen and prevent platelet adhesion and activation. Our goal is to fabricate nanoparticle-SILY by cross-linking SILY to a poly(N-isopropylacrylamide) (NIPAm) nanoparticle instead of a DS backbone, while retaining the SILY’s high collagen binding affinity and platelet inhibition capacity observed in DS-SILY. Using a biotin-streptavidin assay, we …
Growing Impact Of Restenosis On The Surgical Treatment Of Peripheral Arterial Disease, Douglas W. Jones, Andres Schanzer, Yuanyuan Zhao, Todd A. Mackenzie, Brian W. Nolan, Michael S. Conte, Philip P. Goodney
Growing Impact Of Restenosis On The Surgical Treatment Of Peripheral Arterial Disease, Douglas W. Jones, Andres Schanzer, Yuanyuan Zhao, Todd A. Mackenzie, Brian W. Nolan, Michael S. Conte, Philip P. Goodney
Andres Schanzer
BACKGROUND: Patients with peripheral arterial disease often experience treatment failure from restenosis at the site of a prior peripheral endovascular intervention (PVI) or lower extremity bypass (LEB). The impact of these treatment failures on the utilization and outcomes of secondary interventions is poorly understood. METHODS AND RESULTS: In our regional vascular quality improvement collaborative, we compared 2350 patients undergoing primary infrainguinal LEB with 1154 patients undergoing secondary infrainguinal LEB (LEB performed after previous revascularization in the index limb) between 2003 and 2011. The proportion of patients undergoing secondary LEB increased by 72% during the study period (22% of all LEBs …
Transradial Approach In The Diagnosis And Treatment Of Coronary Artery Disease: A 2-Center Experience, Mustafa Yurtdaş, Yüksel Kaya, Edi̇p Gönüllü
Transradial Approach In The Diagnosis And Treatment Of Coronary Artery Disease: A 2-Center Experience, Mustafa Yurtdaş, Yüksel Kaya, Edi̇p Gönüllü
Turkish Journal of Medical Sciences
To document the safety, success, and complications of transradial coronary procedures. Materials and methods: This retrospective study consisted of 427 patients who had undergone transradial coronary angiography and/or angioplasty between June 2010 and May 2012. The main outcome measures were the procedural safety, success rate, and complications associated with transradial interventions. Results: Procedural success rate was 93.2% (398/427), with cannulation time of 2.1 ± 1.4 min, diagnostic time of 5.6 ± 2.1 min, fluoroscopy time of 9.5 ± 6.6 min, and total procedure time of 47.1 ± 20.2 min. The main causes for unsuccessful procedures were failed radial puncture (11 …