Medicine and Health Sciences Commons^™

Synthesis, Structural Characterisation, And Preliminary Evaluation Of Non-Indolin-2-One-Based Angiogenesis Inhibitors Related To Sunitinib (Sutent®), Pichit Sudta, Nicholas Kirk, Anna Bezos, Anthony Gurlica, Rhys Mitchell, Thomas Weber, Anthony C. Willis, Samran Prabpai, Palangpon Kongsaeree, Christopher R. Parish, Sunit Suksamrarn, Michael J. Kelso

Faculty of Science, Medicine and Health - Papers: part A

The indolin-2-one fused-ring system and the 2,4-dimethylpyrrole unit represent key structural motifs in the anticancer drug sunitinib (Sutent®) and predecessor angiogenesis inhibitors that have undergone anticancer clinical trials (e.g. semaxanib, SU5416). In pursuit of novel anti-angiogenic scaffolds, we were interested in identifying whether the indolin-2-one group in these structures could be modified without losing activity. This paper describes novel condensation chemistry used to prepare a test series of (E)- and (Z)-alkenes related to SU5416 that retain the 2,4-dimethylpyrrole unit while incorporating ring-opened indolin-2-ones. Unique structural characteristics were identified in the compounds, such as intramolecular hydrogen bonds in the (Z)-alkenes, and …

Self-Reported Side Effects Of Breast Cancer Treatment: A Cross-Sectional Study Of Incidence, Associations, And The Influence Of Exercise, Sheridan A. Gho, Julie R. Steele, Sandra C. Jones, Bridget J. Munro

Faculty of Science, Medicine and Health - Papers: part A

Purpose Side effects as a result of breast cancer treatment may have a lasting detrimental impact on quality of life. Exercise has been shown to be an effective intervention in post-treatment care. This study aimed to gain a better understanding of breast cancer treatment-related side effects through identifying potential patient characteristic associations, including current levels of exercise.

Methods Four hundred and thirty-two breast cancer patients completed an online survey covering their treatment and demographic background, current exercise levels, and self-reported treatment side effects. Side effects were considered in a binary logistic regression against age, surgery, currently undergoing treatment, and exercise …

A Food Photograph Series For Identifying Portion Sizes Of Culturally Specific Dishes In Rural Areas With High Incidence Of Oesophageal Cancer, Martani Lombard, Nelia Steyn, Hester-Mari Burger, Karen Charlton, Marjanne Senekal

Faculty of Science, Medicine and Health - Papers: part A

Rural areas of the Eastern Cape (EC) Province, South Africa have a high incidence of squamous cell oesophageal cancer (OC) and exposure to mycotoxin fumonisin has been associated with increased OC risk. However, to assess exposure to fumonisin in Xhosas—having maize as a staple food—it is necessary to determine the amount of maize consumed per day. A maize-specific food frequency questionnaire (M-FFQ) has recently been developed. This study developed a food photograph (FP) series to improve portion size estimation of maize dishes. Two sets of photographs were developed to be used alongside the validated M-FFQ. The photographs were designed to …