Medicine and Health Sciences Commons^™

Time-Frequency Analysis Of Transient-Evoked Otoacoustic Emissions In Children Exposed To Carboplatin Chemotherapy, Shaum Bhagat, Johnnie Bass, Ibrahim Qaddoumi, Rachel Brennan, Matthew Wilson, Jianrong Wu, Carlos-Rodriguez Galindo, Alessia Paglialonga, Gabriella Tognola

Faculty Publications

The aims of this study were to characterize and quantify time-frequency changes in transient-evoked otoacoustic emissions (TEOAEs) recorded in children diagnosed with retinoblastoma who were receiving carboplatin chemotherapy. A signal processing technique, the wavelet transform (WT), was used to analyze TEOAE waveforms in narrow-band frequency components. Ten children (aged 3–72 months) diagnosed with unilateral or bilateral retinoblastoma were enrolled in the study. TEOAEs were acquired from the children with linear sequences of 70 dB peak equivalent SPL clicks. After WT analysis, TEOAE energy, latency and normalized energy in the narrow-band frequency components were compared before and during carboplatin chemotherapy treatment …