Medicine and Health Sciences Commons^™

Abstract 2988: Dok2 Suppression By Methylation Induces Platinum Resistance Via Suppression Of Apoptosis In Ovarian Cancer Cells., Noelle L. Cutter Ph.D., Elena Lum, Michelle Vigliotti, Nilanjana Banerjee, Sitharthan Kamalakaran, Kazimierz O. Wrzeszczynski, Sohail Khan, Nevenka Dimitrova, Douglas A. Levine, Robert Lucito

Faculty Works: Biology, Chemistry, and Environmental Studies

Ovarian cancers are highly heterogeneous and while chemotherapy is the preferred treatment, many patients are intrinsically resistant or quickly develop resistance. Furthermore, all tumors that recur will become resistant. Recent evidence suggests that epigenetic deregulation may be a key factor in the onset and maintenance of chemoresistance. To examine the ovarian epigenome, we first analyzed a set of 43 primary ovarian tumors and 9 normal ovarian samples. Since therapy response is a significant issue for ovarian cancer patients we analyzed the epigenetic differences that segregate with platinum response. We then associated expression data to identify genes with expression changes potentially …