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Allergen Sensitization And Immunomodulation By Synthetic Ligands, Pul-042, In An Allergen-Induced Asthma Murine Model, Maryann A. Edwards
Allergen Sensitization And Immunomodulation By Synthetic Ligands, Pul-042, In An Allergen-Induced Asthma Murine Model, Maryann A. Edwards
Dissertations & Theses (Open Access)
Allergen-induced asthma is the leading form of asthma and a chronic condition worldwide. Common allergens are known to contribute to the pathogenesis of this disease. Murine models of allergic asthma have mostly used an intraperitoneal route of sensitization (not airway) to study this disease. Allergic asthma pathophysiology involves the activation of TH2-specific cells, which triggers production of IgE antibodies, the up-regulation of TH2-specific cytokines (i.e. IL-4, IL-5, IL-9 and IL-13), increased airway eosinophilia, and mucin hypersecretion. Although there are several therapeutics currently treating asthmatic patients, some of these treatments can result in drug tolerance and …