Open Access. Powered by Scholars. Published by Universities.®

Medicine and Health Sciences Commons

Open Access. Powered by Scholars. Published by Universities.®

2011

Theses and Dissertations

Virginia Commonwealth University

Traumatic brain injury

Articles 1 - 2 of 2

Full-Text Articles in Medicine and Health Sciences

The Characterization Of The Anterograde And Retrograde Consequences Of Traumatic Axonal Injury In A Mouse Model Of Diffuse Brain Injury, John E. Greer Sep 2011

The Characterization Of The Anterograde And Retrograde Consequences Of Traumatic Axonal Injury In A Mouse Model Of Diffuse Brain Injury, John E. Greer

Theses and Dissertations

Traumatic axonal injury (TAI) is a consistent feature of (TBI) and is responsible for much of its associated morbidity. TAI is now recognized to result from progressive/secondary axonal injury, though much remains unknown in regards to the pathobiology and the long-term consequences of axonal injury. TAI has been described in the perisomatic domain, located within the neocortex following mild TBI, and within this domain has been linked to neuronal recovery, not neuronal cell death in the acute setting. Due to technical limitations, our understanding of the long-term fate of this neuronal population and the mechanisms responsible for permitting neuronal survival, …


Characterization Of A Blast Wave Device And Blast Wave Induced Traumatic Brain Injury In A Rat Model By Magnetic Resonance Imaging And Spectroscopy, Frank Corwin Apr 2011

Characterization Of A Blast Wave Device And Blast Wave Induced Traumatic Brain Injury In A Rat Model By Magnetic Resonance Imaging And Spectroscopy, Frank Corwin

Theses and Dissertations

Blast wave induced traumatic brain injury (bTBI) is a modality of injury that has come into prominence at the current time due to the large number of military and civilian personnel who have experienced the localized shock wave produced by explosive devices. The shock wave will travel concentrically outward from the explosive center, being absorbed and transmitted thru soft objects, such as tissue, and reflecting off stationary obstructions. Transmission and absorption in tissues can result in a number of physiological measureable injuries, the most common of which being what is frequently called “blast lung”. Blast lung involves the spalling effect …