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Articles 1 - 7 of 7
Full-Text Articles in Medicine and Health Sciences
The Neuropsychological Effects Of Combined Physical And Mental Exercise In Schizophrenia, Maggie M. Manning
The Neuropsychological Effects Of Combined Physical And Mental Exercise In Schizophrenia, Maggie M. Manning
Honors Theses
People suffering from severe mental disorders encounter many debilitating side effects. Those diagnosed with schizophrenia face a large number of challenges each day. Not only must they endure symptoms, like hallucinations and delusions, commonly associated with the illness, but their higher-level cognitive functioning is further impaired in numerous ways. People with schizophrenia, suffering from thought disorder, battle with a pattern of disorganized thinking in which seemingly simple tasks, i.e attention and memory, are difficult. Negative symptoms include the inability to establish social relationships, and hinder their everyday experiences, including work. Their extremely sedentary lifestyle also negatively impacts engagement in other …
Metacaspase Gene Function In The Mushroom Fungus Schizophyllum Commune, Matthew P. Hanley
Metacaspase Gene Function In The Mushroom Fungus Schizophyllum Commune, Matthew P. Hanley
Honors Theses
The overall goal of this project was to investigate the biological role of a putative metacaspase gene present in the mushroom fungus Schizophyllum commune. For this study, we have utilized a strain of S. commune that is unable to integrate DNA via the non-homologous end joining pathway. This forces transforming DNA to integrate homologously, as is required for the purposes of gene knockout. The gene Scp1 encodes a likely member of the metacaspase protein family, which are suspected to have activity similar to caspases, the latter crucial to programmed cell death. A knockout construct containing a non-functional version of Scp1 …
Development Of A Robust Genetic Test For Hyperkalemic Periodic Paralysis (Hypp) In Quarter Horses, Samantha Traver
Development Of A Robust Genetic Test For Hyperkalemic Periodic Paralysis (Hypp) In Quarter Horses, Samantha Traver
Honors Theses
A single nucleotide substitution in a region of the skeletal muscle sodium channel gene (SCN4A) is known to cause an equine genetic disorder known as Hyperkalemic Periodic Paralysis (HYPP). The clinical effects of this disorder range from little or no symptoms to frequent episodes of muscle tremors, weakness, and/or complete collapse. Oligonucleotide primer pairs were designed for both the wild type and mutant alleles of the SCN4A gene for use in Amplification Refractory Mutation System-PCR (ARMS-PCR). These primers were tested with genomic DNA isolated from whole blood, saliva swabs, and hair of individual horses. It was determined that horse hair …
Effects Of Arginine On The Kinetics Of Bovine Insulin Aggregation Studied By Dynamic Light Scattering, Michael M. Varughese
Effects Of Arginine On The Kinetics Of Bovine Insulin Aggregation Studied By Dynamic Light Scattering, Michael M. Varughese
Honors Theses
In the fields of protein science and medicine, understanding the kinetics of protein aggregation are significant in the research and treatment of certain amyloid diseases such as Alzheimer’s. Previous studies have suggested that arginine can increase the solubility of certain proteins, suppress protein aggregation, and assist in the refolding of aggregated proteins; however, the molecular mechanisms by which arginine can influence protein aggregation are still unclear. Bovine insulin was employed as a model system for further understanding the effects of arginine on protein aggregation. Using Dynamic Light Scattering (DLS), we studied the concentration-dependent and temperature-dependent suppression of aggregation in insulin …
Neuropsychological And Neurophysiological Effects Of Low-Intensity Strengthening Exercise On Cognition, Vadim V. Yerokhin
Neuropsychological And Neurophysiological Effects Of Low-Intensity Strengthening Exercise On Cognition, Vadim V. Yerokhin
Honors Theses
With the growing aging population, it’s becoming increasingly important to find ways to either deter or prevent dementia. To date, most research has concentrated on the effects of aerobic exercise on cognition. Unfortunately, a large portion of older adults are often contraindicated to perform aerobic exercise due to different risk factors, which increase with age. Alas, alternate ways of exercise are necessary. Low-intensity strengthening exercise is a type of exercise aimed at improving balance and strengthening muscles without requiring one to overstrain. The current 11-week long exercise study test neuropsychological effects of exercise with a neuropsychological battery and neurophysiological effects …
A Review Of Literature For Osteology: Cell Biology, Tissue Biology, And The Application Of Synthetic Compounds For The Facilitation Of Bone Tissue Repair, Ryan T. Jones
Honors Theses
Bone is a dynamic matter that provides support, structure, mineral reserves, and stem cell reserves for the body. Important functions range from structural support for the body to roles in maintaining homeostasis. Structure and support for the body is the most obvious role, with the skeletal system as a whole providing a normal force for other tissues and organs to resist gravity. Protection is also inferred for tissues and organs from impacting forces, especially with axial bones covering vital organs in the thoracic cavity. Another function of bone includes the ability to store and release minerals when needed to maintain …
The Impact Of Tricaine Methanesulfonate, 2-Phenoxyethanol, And Carvone-Methyl Salicylate On The Innate Immune Response Of Zebrafish (Danio Rerio), Charles R. Wulff
The Impact Of Tricaine Methanesulfonate, 2-Phenoxyethanol, And Carvone-Methyl Salicylate On The Innate Immune Response Of Zebrafish (Danio Rerio), Charles R. Wulff
Honors Theses
Anesthesia plays a vital role in the maintenance of aquaculture species, where it is used to minimize stress during complex handling tasks such as transport, assessment, and harvesting. However, anesthetics have been shown to suppress the innate immune response, which could impact immunity and increase risk of infection. Tricaine methanesulfonate (MS-222) and 2-Phenoxyethanol (2-PE) represent two of the most commonly used anesthetics in aquaculture, with R-(+)-carvone, in the form of carvone-methyl salicylate (CMS) has recently been proposed as an alternative anesthetic for food fish. These three anesthetics were used to assess the influence of anesthetics on the immune system of …