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Full-Text Articles in Medicine and Health Sciences

Brachytherapy Seed And Applicator Localization Via Iterative Forward Projection Matching Algorithm Using Digital X-Ray Projections, Damodar Pokhrel Oct 2010

Brachytherapy Seed And Applicator Localization Via Iterative Forward Projection Matching Algorithm Using Digital X-Ray Projections, Damodar Pokhrel

Theses and Dissertations

Interstitial and intracavitary brachytherapy plays an essential role in management of several malignancies. However, the achievable accuracy of brachytherapy treatment for prostate and cervical cancer is limited due to the lack of intraoperative planning and adaptive replanning. A major problem in implementing TRUS-based intraoperative planning is an inability of TRUS to accurately localize individual seed poses (positions and orientations) relative to the prostate volume during or after the implantation. For the locally advanced cervical cancer patient, manual drawing of the source positions on orthogonal films can not localize the full 3D intracavitary brachytherapy (ICB) applicator geometry. A new iterative forward …


Adherence To The American College Of Surgeons (Acs) Recommendation On Double Gloving, Hand Free Zone And Blunt Suture Needle Use Among Surgeon Ranks, Akbar Nassiry Aug 2010

Adherence To The American College Of Surgeons (Acs) Recommendation On Double Gloving, Hand Free Zone And Blunt Suture Needle Use Among Surgeon Ranks, Akbar Nassiry

Theses and Dissertations

Background: The American College of Surgeons guidelines suggest the use of intact gloves, double gloving, hands-free zone technique to pass sharp instruments, and blunt tip suture needles to protect patients, as well as the surgical team. This study estimates the extent to which these guidelines are followed in a large academic health system. Methods: Over a two-month period in the spring of 2010, 320 general surgical attendings, subspecialty surgical attendings, and surgical resident physicians practicing at a large academic health system, were approached during or after surgical conferences to participate in a cross-sectional study. Nearly 1/3rd completed an anonymous and …


The Development And Use Of A Geographic Information System For Evaluating The Association Between Pesticide Exposure And Prostate Cancer, Kristen Wells Jul 2010

The Development And Use Of A Geographic Information System For Evaluating The Association Between Pesticide Exposure And Prostate Cancer, Kristen Wells

Theses and Dissertations

Abstract 1 – A Geographic Information System for Evaluating Residential Pesticide Exposure and Prostate Cancer Incidence Agricultural pesticide exposure is hypothesized to be a risk factor for prostate cancer, and such exposures are of particular concern for men living in farming communities where large-scale pesticide applications occur. Prostate cancer incidence data were obtained from the State Health Registry of Iowa for the years 1996 through 2006, and county and census tract level age-adjusted incidence rates were calculated. Historical crop-specific land use records and pesticide sales data for the state of Iowa during 1990 were integrated into a geographic information system …


The Association Between Teen Parenthood And Marital Status Among Women, Amy Feinberg May 2010

The Association Between Teen Parenthood And Marital Status Among Women, Amy Feinberg

Theses and Dissertations

Introduction: Teen pregnancy and teen parenting are prevalent and significant public health issues. Teen parenting also has many social and economic consequences for mother and family. Single parenthood is associated with increased financial, work and child care strains compared to a more traditional family type. Therefore, the impact of teen pregnancy on marital status needs to be investigated. This study examines the association between teen parenthood and future marital status. Methods: The 2002 National Survey of Family Growth, Cycle 6 was analyzed. This study included 12398 women age 20 – 44 years who had children. Teen parenthood was defined as …


A Qualitative Approach To Explore The Experiences Of Health Care Providers Who Treat Patients For Post Traumatic Stress Disorder (Ptsd), Mark Killebrew May 2010

A Qualitative Approach To Explore The Experiences Of Health Care Providers Who Treat Patients For Post Traumatic Stress Disorder (Ptsd), Mark Killebrew

Theses and Dissertations

Post Traumatic Stress Disorder (PTSD) is an anxiety disorder that occurs when people are exposed to stressful, life-threatening experiences. Consequently, after exposure to such an event, many people may experience fear, guilt, or anger and may believe the trauma is reoccurring. According to the National Institute of Mental Health, approximately 5.2 million U.S. adults age 18-54 have PTSD in any given year. The prevalence of PTSD is even more problematic within the military where an estimated 30% of those who have spent time in war zones experiences PTSD. Researchers have been examining the impact of veterans’ PTSD symptoms on family …


A Community-Engaged Research Approach To The Development Of An Assessment Tool For Historical Data Collection Of Saara Client Population, Jessica Markey May 2010

A Community-Engaged Research Approach To The Development Of An Assessment Tool For Historical Data Collection Of Saara Client Population, Jessica Markey

Theses and Dissertations

Through collaboration between the Substance Abuse and Addiction Recovery Alliance (SAARA) and several community partners, a need was identified for a new measurement tool to gather comprehensive client histories for program evaluation and development. The purpose of this study was to (1) develop a culturally relevant and organizationally appropriate mechanism for the collection of comprehensive client histories and (2) to provide the opportunity for staff to engage in a new process of developing and implementing data collection strategies. As a result of the use of a community-based participatory approach, (1) a missed opportunity for program evaluation and development was identified, …


Statin Use And The Risk Of Clostridium Difficile In Academic Medical Centers: A Matched Case Control Study, Christine Motzkus May 2010

Statin Use And The Risk Of Clostridium Difficile In Academic Medical Centers: A Matched Case Control Study, Christine Motzkus

Theses and Dissertations

BACKGROUND: Increasing rates of hospital acquired Clostridium difficile (CDI), as well as mortality owing to CDI, warrants further exploration of risk factors. Clostridium difficile bacteria typically produce toxins which inactivate the Rho proteins found in the colonic epithelium. Statins also disrupt Rho protein cell signaling functions. The objective of this study was to estimate the extent to which use of statins increases the risk of healthcare-acquired CDI. METHODS: Patients over 18 years of age admitted to hospitals contributing data to the University HealthSystem Consortium between 2002 and 2009 were eligible. We identified 25, 111 incident cases of CDI and matched …


The Relationship Between Treatment-Seeking And Characteristics Of Depression Among African Americans, Tamara Scott May 2010

The Relationship Between Treatment-Seeking And Characteristics Of Depression Among African Americans, Tamara Scott

Theses and Dissertations

Objective: Depression is a common psychiatric condition, and despite the availability of effective treatments, this condition is largely under-recognized and undertreated, particularly among African Americans. One reason for this discrepancy may be that depressive symptoms often co-occur with physical health conditions, which can influence both the reporting of depressive symptomology, willingness to seek care, and the type of healthcare provider sought. The purpose of this study was to explore the relationship between treatment-seeking characteristics and diagnostic attributions of depression among community-dwelling African American adults. Methods: Data come from the National Survey of American Life, a nationally representative sample of African …


Strategies For Deriving A Single Measure Of The Overall Burden Of Antimicrobial Resistance In Hospitals, Alessandro Orlando May 2010

Strategies For Deriving A Single Measure Of The Overall Burden Of Antimicrobial Resistance In Hospitals, Alessandro Orlando

Theses and Dissertations

Background: Antimicrobial-resistant infections result in hospital stays costing between $18,000 and $29,000. As of 2009, Centers for Medicare and Medicaid Services no longer upgrade payments for hospital-acquired infections. Hospital epidemiologists monitor and document rates of individual resistant microbes in antibiogram reports. Overall summary measures capturing resistance within a hospital may be useful. Objectives: We applied four techniques (L1- and L2-principal component analysis (PCA), desirability functions, and simple summary) to create summary measures of resistance and described the four summary measures with respect to reliability, proportion of variance explained, and clinical utility. Methods: We requested antibiograms from hospitals participating in the …


The Effect Of Medicaid Policy Reform On Dental Utilization Rates For Children, Matthew Winheim May 2010

The Effect Of Medicaid Policy Reform On Dental Utilization Rates For Children, Matthew Winheim

Theses and Dissertations

Background: Regular access to dental services is a well-known factor in the oral health and development of children.1 As such, the United States federal government mandates each state to include dental services for children enrolled in Medicaid through the age of 21. Despite this mandate, the utilization rate of dental services among Medicaid enrolled children has remained remarkably low.2 In July 2005, Virginia implemented a sweeping Medicaid policy reform titled “Smiles for Children,” specifically aiming to increase Medicaid pediatric dental utilization rates. The purpose of this study aims to assess the effect of this 2005 policy reform on the utilization …


Nonmedical Prescription Drug Use On College Campuses: Risk Factors For Abuse, Jennifer Barber May 2010

Nonmedical Prescription Drug Use On College Campuses: Risk Factors For Abuse, Jennifer Barber

Theses and Dissertations

Background: In recent years, there has been an increase in prescription drug abuse, particularly among adolescents and young adults. While substance abuse on college campuses has remained a pervasive public health concern, rates of nonmedical prescription drug use surpass commonly abused drugs. The three most commonly abused prescription drugs (central nervous system (CNS) depressants, opioids, and stimulants) were assessed to identify differences among student characteristics, as well as their relationship with abuse. Purpose: The purpose of this study is to conduct a secondary analysis to explore demographic variables (race, gender, academic performance, living arrangement, alcohol and other drug usage, and …


The Association Between Domestic Violence, Hiv Status And Consent To Testing Among Zambian Women, Kara Nelson May 2010

The Association Between Domestic Violence, Hiv Status And Consent To Testing Among Zambian Women, Kara Nelson

Theses and Dissertations

In the past twenty years a global trend has emerged illustrating increasing rates of violence against women, with HIV rates among this population also steadily on the rise. Despite the burden of the problem, there is scant corpus of literature exploring the influence of domestic violence on HIV. Therefore, this study examined the association between domestic violence and women’s decision to consent to HIV testing, and their HIV status. Using the 2007 Zambia Demographic and Health Survey, it was found that Zambian women who have experienced domestic violence are 13% more likely to consent to an HIV test. After adjusting …


Master Of Public Health Research Project: Unmarried Women In Ghana, Africa: Predictors Of Condom Use- An Analysis Of The 2008 Ghana Demographic And Health Survey/Questionnaire Database, Emilie Hill May 2010

Master Of Public Health Research Project: Unmarried Women In Ghana, Africa: Predictors Of Condom Use- An Analysis Of The 2008 Ghana Demographic And Health Survey/Questionnaire Database, Emilie Hill

Theses and Dissertations

Background: Many factors affect whether women will insist that their sexual partners use a condom. This research project will identify some of the predictors of condom use among unmarried women in Ghana, Africa. Methods: This research project evaluated data from the 2008 DHS of women in Ghana, Africa for predictors of condom use among unmarried women. A total of 4,916 women completed the surveys. Of these, 1,966 women were unmarried. The research project employed multiple logistic regression analysis to determine condom use predictors at the time of the last sexual encounter for these 1,966 unmarried women. Results: Women with a …


Is Food Insecurity A Contributing Factor To Childhood Obesity? The Association Of Household Food Insecurity And Obesity Prevalence Among Children And Adolescents In The United States, Zarah Liz Panaguiton May 2010

Is Food Insecurity A Contributing Factor To Childhood Obesity? The Association Of Household Food Insecurity And Obesity Prevalence Among Children And Adolescents In The United States, Zarah Liz Panaguiton

Theses and Dissertations

The obesity epidemic is a major public health concern, where the prevalence rates amongst the American children population have more than doubled since the 1980s. Among overweight children, the risk of becoming an overweight or obese adult is 70% higher than children of normal weight, and obese children are more likely to remain obese into adulthood and face a number of morbidities associated with it, including lower quality of life and increased financial burden. In this research, we examined the relationship between household food security and obesity among children and adolescents between the ages of 2-18 years old. We used …


The Epidemiology Of Snakebite Injury In The Amazonian Regions Of Ecuador, Sarah Stuppy May 2010

The Epidemiology Of Snakebite Injury In The Amazonian Regions Of Ecuador, Sarah Stuppy

Theses and Dissertations

The epidemiology of snakebite injury in the Amazonian regions of Ecuador Introduction: Morbidity and mortality from snakebite envenomations is a major public health issue in remote areas of under-developed countries. Several attempts have been made to approximate the impact of snakebites worldwide, however these are assumed to be underestimations due to the lack of documentation on the local level. Ecuador's Amazonian region lacks a comprehensive community-based surveillance system, however it is unique in that an aero-medical transport system is in place to transfer the patients requiring hospitalization to one of the five urban medical centers. Beginning in 1998, Servicio Aéreo …


The Association Between Prenatal Care Content And Quality With Preterm Birth And Maternal Postpartum Health Behaviors, Susan Cha May 2010

The Association Between Prenatal Care Content And Quality With Preterm Birth And Maternal Postpartum Health Behaviors, Susan Cha

Theses and Dissertations

Background: Health policies that seek to improve pregnancy outcomes focus on increasing the availability and access to prenatal care (PNC) services based on studies that support an association between insufficient PNC and adverse birth outcomes. These studies employ PNC utilization indices that measure the adequacy of PNC use, but these indices fail to account for the content or specific components of PNC. Objectives: The purpose of this study was to utilize PRAMS and birth certificate data to evaluate the content and quality of PNC in Virginia, and its impact on preterm birth and maternal postpartum health behaviors. Methods: Data was …


When Volunteering Doesn’T Cut It: A Critical Examination Of Carbapenem-Resistant Enterobacteriaceae Surveillance And Trends In The United States., Erica E. Smith May 2010

When Volunteering Doesn’T Cut It: A Critical Examination Of Carbapenem-Resistant Enterobacteriaceae Surveillance And Trends In The United States., Erica E. Smith

Theses and Dissertations

Background. Carbapenem-resistant Enterobacteriaceae, including Escherichia coli and Klebsiella pneumoniae, are newly emerging pathogens of public health importance. Currently no nationally representative or mandatory surveillance or reporting system exists to examine trends of these important pathogens. Objective. The purpose of the current study was to estimate trends in overall microbial burden and carbapenem resistance in E. coli and K. pneumoniae and to understand the extent to which hospitals which report to voluntary surveillance systems represent all hospitals in the United States. Design. We conducted a descriptive study to compare the hospitals participating in voluntary reporting systems of the University HealthSystem Consortium …


Sensitivity Analysis – The Effects Of Glasgow Outcome Scale Misclassification On Traumatic Brain Injury Clinical Trials, Juan Lu Apr 2010

Sensitivity Analysis – The Effects Of Glasgow Outcome Scale Misclassification On Traumatic Brain Injury Clinical Trials, Juan Lu

Theses and Dissertations

I. EFFECTS OF GLASGOW OUTCOME SCALE MISCLASSIFICATION ON TRAUMATIC BRAIN INJURY CLINICAL TRIALS The Glasgow Outcome Scale (GOS) is the primary endpoint for efficacy analysis of clinical trials in traumatic brain injury (TBI). Accurate and consistent assessment of outcome after TBI is essential to the evaluation of treatment results, particularly in the context of multicenter studies and trials. The inconsistent measurement or interobserver variation on GOS outcome, or for that matter, on any outcome scales, may adversely affect the sensitivity to detect treatment effects in clinical trial. The objective of this study is to examine effects of nondifferential misclassification of …


Particulate Characterization And Control Evaluation For Carbon Fiber Composite Aircraft Crash Recovery Operations, Matthew R. Ferreri Mar 2010

Particulate Characterization And Control Evaluation For Carbon Fiber Composite Aircraft Crash Recovery Operations, Matthew R. Ferreri

Theses and Dissertations

Within the United States Air Force (USAF) Advanced Composite Material (ACM) is gaining an increasing use in military aircraft. With the number of aircraft that have increasingly large amounts of ACM materials, the probability of an incident with one of these aircraft also increases. When such an incident occurs the aircraft needs to be disassembled, removed, and later inspected as part of the accident investigation process. This disassembly process is termed “Crash Recovery Operations.” Carbon fibers have been shown to be hazardous to human health and a pilot study raised the suspicion that nanosized aerosol may be generated during the …


High Volume Air Sampling For Viral Aerosols: A Comparative Approach, Casey W. Cooper Mar 2010

High Volume Air Sampling For Viral Aerosols: A Comparative Approach, Casey W. Cooper

Theses and Dissertations

The United States Air Force has high volume biological air sampling equipment available including the XMX/2L-MIL and DFU-1000. Neither system has been evaluated for effectiveness in the collection of viruses. Furthermore, decontamination methods have not been evaluated for these systems after use in sampling for a viral agent. MS2 bacteriophage was used as a surrogate virus. Aerosolized MS2 was released into a 12 m3 exposure chamber. High and moderate airborne concentrations of MS2 were evaluated. Low volume impingers were used for comparative purposes as well. Samples were analyzed using plaque assay and polymerase chain reaction (PCR). At high viral loads …


Development Of A Novel Noise Delivery System For Jp-8 Ototoxicity Studies, John E. Stubbs Mar 2010

Development Of A Novel Noise Delivery System For Jp-8 Ototoxicity Studies, John E. Stubbs

Theses and Dissertations

Numerous chemicals with ototoxic properties may cause hearing loss directly, potentiate noise-induced hearing loss, or produce additive effects. Of interest to the US Air Force are studies showing ototoxic effects of JP-8 jet fuel and its hydrocarbon constituents. The Naval Health Research Center (NHRC) at Wright-Patterson AFB, Ohio, in conjunction with the USAF, is studying the ototoxic effects of JP-8 in rats. The study requires a white noise source that is one octave band wide, centered at 8 kHz frequency, delivered from outside of exposure chambers. Sound pressure levels must be within ± 2 dB at all exposure points within …