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Distinct Neural Mechanisms Underlying Acute And Repeated Administration Of Antipsychotic Drugs In Rat Avoidance Conditioning, Ming Li, Tao Sun, Chen Zhang, Gang Hu
Distinct Neural Mechanisms Underlying Acute And Repeated Administration Of Antipsychotic Drugs In Rat Avoidance Conditioning, Ming Li, Tao Sun, Chen Zhang, Gang Hu
Department of Psychology: Faculty Publications
Rationale — Acute antipsychotic treatment disrupts conditioned avoidance responding, and repeated treatment induces a sensitization- or tolerance-like effect. However, the neurochemical mechanisms underlying both acute and repeated antipsychotic effects remain to be determined.
Objective — The present study examined the neuroreceptor mechanisms of haloperidol, clozapine, and olanzapine effect in a rat two-way conditioned avoidance model.
Methods — Well-trained Sprague–Dawley rats were administered with haloperidol (0.05 mg/kg, sc), clozapine (10.0 mg/ kg, sc), or olanzapine (1.0 mg/kg, sc) together with either saline, quinpirole (a selective dopamine D2/3 agonist, 1.0 mg/ kg, sc), or 2,5-dimethoxy-4-iodo-amphetamine (DOI; a selective 5-HT2A/2C agonist, 2.5 mg/kg, …