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Full-Text Articles in Medicine and Health Sciences
Estrogen Regulates Estrogen Receptors And Antioxidant Gene Expression In Mouse Skeletal Muscle, Kristen A. Baltgalvis, Sarah M. Greising, Gordon L. Warren, Dawn A. Lowe
Estrogen Regulates Estrogen Receptors And Antioxidant Gene Expression In Mouse Skeletal Muscle, Kristen A. Baltgalvis, Sarah M. Greising, Gordon L. Warren, Dawn A. Lowe
Physical Therapy Faculty Publications
Background: Estrogens are associated with the loss of skeletal muscle strength in women with age. Ovarian hormone removal by ovariectomy in mice leads to a loss of muscle strength, which is reversed with 17β-estradiol replacement. Aging is also associated with an increase in antioxidant stress, and estrogens can improve antioxidant status via their interaction with estrogen receptors (ER) to regulate antioxidant gene expression. The purpose of this study was to determine if ER and antioxidant gene expression in skeletal muscle are responsive to changes in circulating estradiol, and if ERs regulate antioxidant gene expression in this tissue.
Methodology/Principal Findings: Adult …