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The Validity Of Cocaine Dependence Subtypes, Henry R. Kranzler, Victor M. Hesselbrock

UCHC Articles - Research

Cocaine dependence (CD) is a multifactorial disorder, variable in its manifestations, and heritable. We examined the concurrent validity of homogeneous subgroups of CD as phenotypes for genetic analysis. We applied data reduction methods and an empirical cluster-analytic approach to measures of cocaine use, cocaine-related effects, and cocaine treatment history in 1393 subjects, from 660 small nuclear families. Four of the six clusters that were derived yielded heritability estimates in excess of 0.3. Linkage analysis showed genomewide significant results for two of the clusters. Here we examine the concurrent validity of the six clusters using a variety of demographic and substance-related …