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Articles 1 - 2 of 2
Full-Text Articles in Medicine and Health Sciences
"It Doesn't Do Any Harm, But Patients Feel Better": A Qualitative Exploratory Study On Gastroenterologists' Perspectives On The Role Of Antidepressants In Inflammatory Bowel Disease, Antonina A. Mikocka-Walus, Deborah Turnbull, Nicole T. Moulding, Ian G. Wilson, Jane M. Andrews, Gerald J. Holtmann
"It Doesn't Do Any Harm, But Patients Feel Better": A Qualitative Exploratory Study On Gastroenterologists' Perspectives On The Role Of Antidepressants In Inflammatory Bowel Disease, Antonina A. Mikocka-Walus, Deborah Turnbull, Nicole T. Moulding, Ian G. Wilson, Jane M. Andrews, Gerald J. Holtmann
Graduate School of Medicine - Papers (Archive)
Background: Interest in psychological factors in patients with inflammatory bowel disease (IBD) has increased in recent years. It has even been proposed that treating psychological co-morbidities with antidepressants may control disease activity and improve quality of life. Despite this, there is no data on gastroenterologists' attitudes to, and experiences with, antidepressant therapy in patients with IBD. Methods: We conducted semi-structured interviews with 18 gastroenterologists associated with metropolitan teaching hospitals. Qualitative content analysis was used to examine their responses. Results: Seventy-eight percent of gastroenterologists had treated IBD patients with antidepressants for pain, depression and/or anxiety, and insomnia. Antidepressants were reported to …
Effect Of Different Drugs Influencing Monoamine Neurotransmission On Haloperidol-Induced Catalepsy In Mice, Omar Mohamed Abdel-Salam, Ayman Ragab Baiuomy
Effect Of Different Drugs Influencing Monoamine Neurotransmission On Haloperidol-Induced Catalepsy In Mice, Omar Mohamed Abdel-Salam, Ayman Ragab Baiuomy
Turkish Journal of Medical Sciences
Aim: Catalepsy occurs following high dopamine D2 receptor blockade by the typical antipsychotic drug haloperidol. The present study investigated the effect of different drugs affecting monoamine neurotransmission in this animal model of Parkinson's disease in mice. Materials and Methods: Drugs were intraperitoneally administered with haloperidol 30 min prior to testing. Catalepsy was measured using the bar test. Results: Catalepsy duration was reduced by the non-selective noradrenaline and serotonin reuptake inhibitors imipramine and amitriptyline (21.1% and 22.3% reduction by 20 mg/kg imipramine and amitriptyline, respectively). Catalepsy duration was increased by the selective serotonin reuptake inhibitors (SSRIs) fluoxetine, fluvoxamine, and citalopram and …