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Case-cohort design; HIV vaccine trial; Interval censoring; Proportional hazards model; Random dropout; Weighted likelihood
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Weighted Likelihood Method For Grouped Survival Data In Case-Cohort Studies With Application To Hiv Vaccine Trials, Zhiguo Li, Peter B. Gilbert, Bin Nan
Weighted Likelihood Method For Grouped Survival Data In Case-Cohort Studies With Application To Hiv Vaccine Trials, Zhiguo Li, Peter B. Gilbert, Bin Nan
The University of Michigan Department of Biostatistics Working Paper Series
Grouped failure time data arise often in HIV studies. In a recent preventive HIV vaccine efficacy trial, immune responses generated by the vaccine were measured from a case-cohort sample of vaccine recipients, who were subsequently evaluated for the study endpoint of HIV infection at pre-specified follow-up visits. Gilbert et al. (2005) and Forthal et al. (2007) analyzed the association between the immune responses and HIV incidence with a Cox proportional hazards model, treating the HIV infection diagnosis time as a right censored random variable. The data, however, are of the form of grouped failure time data with case-cohort covariate sampling, …