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Effects Of Atp-Mgcl_2 On Myocardial Ischemia-Reperfusion Injury: An In Vivo Experimental Study, Zülfi̇kar Kadi̇r Saritaş, Nusret Apaydin, Fatma Eser Özgenci̇l, Kamuran Pamuk, A. Tulga Ulus, Ayşen Aksoyek, Ufuk Tütün, Ali̇ İhsan Parlar, Sali̇h Fehmi̇ Katircioğlu
Effects Of Atp-Mgcl_2 On Myocardial Ischemia-Reperfusion Injury: An In Vivo Experimental Study, Zülfi̇kar Kadi̇r Saritaş, Nusret Apaydin, Fatma Eser Özgenci̇l, Kamuran Pamuk, A. Tulga Ulus, Ayşen Aksoyek, Ufuk Tütün, Ali̇ İhsan Parlar, Sali̇h Fehmi̇ Katircioğlu
Turkish Journal of Veterinary & Animal Sciences
We investigated the effect of ATP-MgCl_2 on myocardial hemodynamics and metabolism. The study included 12 mongrel dogs that were randomly divided into 2 groups: the control and the ATP-MgCl_2 (study) groups. Following a right thoracotomy, the left anterior descending artery was ligated for 15 min and then reperfusion was performed. After the ischemic period, cardiopulmonary bypass was initiated and the aorta was cross-clamped. ATP-MgCl_2 (70+70 mmol/l) 0.25 ml/kg per h was given to the study group at the start of the ischemic period. Hemodynamic and metabolic measurements were obtained at basal, and then after 60, 120, and 180 min of …
The Effects On Myocardial Improvement Using Atp-Mgcl_2 During The Ischemia Reperfusion Period; An In Vitro Study, Nusret Apaydin, Zülfi̇kar Kadi̇r Saritaş, Kamuran Pamuk, Fatma Eser Özgenci̇l, Fulya Ocak, Tulga Ulus, Baran Budak, Selçuk Sürücü, Sali̇h Fehmi̇ Katircioğlu
The Effects On Myocardial Improvement Using Atp-Mgcl_2 During The Ischemia Reperfusion Period; An In Vitro Study, Nusret Apaydin, Zülfi̇kar Kadi̇r Saritaş, Kamuran Pamuk, Fatma Eser Özgenci̇l, Fulya Ocak, Tulga Ulus, Baran Budak, Selçuk Sürücü, Sali̇h Fehmi̇ Katircioğlu
Turkish Journal of Veterinary & Animal Sciences
We investigated the effect of ATP-MgCl_2 on myocardial hemodynamics and ultrastructure. In the in vitro study, left ventricular systolic and diastolic pressures and dp/dt values were significantly high in the ATP-MgCl_2 group beginning from 0.5 h of the reperfusion period. In the ATP-MgCl_2 group, at the end of the third hour, systolic and diastolic pressure values were 80.0 ± 6.2 and 75.2 ± 7.2 mmHg, while in the control group they were 18.4 ± 7.7 and 7.5 ± 6.8 mmHg (P < 0.05). In the ultrastructural analysis, myofibrillary damage was observed in both groups, but the mitochondrial pathologic changes were clearer in the control group. The electron microscopic score was 0.40 ± 0.061 in the ATP-MgCl_2 group and 1.2 ± 0.039 in the control group (P < 0.001). The hemodynamic and ultrastructural parameters of the specimens investigated in this study revealed that the usage of ATP-MgCl_2 may be beneficial in coping with ischemia-reperfusion damage. In the near future, with the help of more comprehensive studies, ATP-MgCl_2 is expected to be used routinely because of its potential benefits.