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Appl1 Associates With Trka And Gipc1 And Is Required For Nerve Growth Factor-Mediated Signal Transduction, D. C. Lin, C. Quevedo, N. E. Brewer, A. Bell, J. R. Testa, Mark L. Grimes, F. D. Miller, D. R. Kaplan
Appl1 Associates With Trka And Gipc1 And Is Required For Nerve Growth Factor-Mediated Signal Transduction, D. C. Lin, C. Quevedo, N. E. Brewer, A. Bell, J. R. Testa, Mark L. Grimes, F. D. Miller, D. R. Kaplan
Biomedical and Pharmaceutical Sciences Faculty Publications
The neurotrophin receptor TrkA plays critical roles in the nervous system by recruiting signaling molecules that activate pathways required for the growth and survival of neurons. Here, we report APPL1 as a TrkA-associated protein. APPL1 and TrkA coirnmunoprecipitated in sympathetic neurons. We have identified two routes through which this association can occur. APPL1 was isolated as a binding partner for the TrkA-interacting protein GIPC1 from rat brain lysate by mass spectrometry. The PDZ domain of GIPC1 directly engaged the C-terminal sequence of APPL1. This interaction provides a means through which APPL1 may be recruited to TrkA. In addition, the APPL1 …
Nested Case-Control Study Of Autoimmune Disease In An Asbestos-Exposed Population, Curis W. Noonan, Jean C. Pfau, Theodore C. Larson, Michael R. Spence
Nested Case-Control Study Of Autoimmune Disease In An Asbestos-Exposed Population, Curis W. Noonan, Jean C. Pfau, Theodore C. Larson, Michael R. Spence
Biomedical and Pharmaceutical Sciences Faculty Publications
OBJECTIVE: To explore the potential association between asbestos exposure and risk of autoimmmune disease, we conducted a case-control study among a cohort of 7,307 current and former residents of Libby, Montana, a community with historical occupational and environmental exposure to asbestos-contaminated vermiculite. METHODS: Cases were defined as those who reported having one of three systemic autoimmune diseases (SAIDs): systemic lupus erythematosus, scleroderma, or rheumatoid arthritis (RA). Controls were randomly selected at a 3:1 ratio from among the remaining 6,813 screening participants using frequency-matched age and sex groupings. RESULTS: The odds ratios (ORs) and 95% confidence intervals (CIs) for SAIDs among …