Medicine and Health Sciences Commons^™

Genetics And Functions Of Herpes Simplex Virus Type 1 Membrane Proteins In Virus-Induced Cell Fusion, Virion Morphogenesis And Egress, Jeffrey Michael Melancon

LSU Doctoral Dissertations

The Herpes Simplex Virus life cycle contains a number of membrane fusion events that must function properly to ensure a productive infection, including: virus attachment and entry into susceptible cells, de-envelopment at the outer nuclear lamellae, and virus-induced cell-to-cell fusion. A virus-free cell fusion assay was recently developed in order to attempt to understand the underlying mechanisms that are responsible for viral fusion events and was utilized in order to investigate the effect of mutations targeted to the carboxyl terminus of gB. We showed that the predicted alpha helical domain H17b within the carboxyl-terminus of gB is involved in both …