Medicine and Health Sciences Commons^™

Screening At Worksite Applying The Framingham Heart Study Score., Paulo A. Lotufo

Paulo A Lotufo

The first evaluation of class of occupation and cardiovascular risk factors in a Brazilian sample of civil servants. 1) context: Cardiovascular diseases are the main causes of death in Brazil. The high-risk approach to cardiovascular risk factors by screening test at worksite is one possible strategy of prevention. 2) objective: to verify the impact of a risk factors screening according to occupational levels. 3) type of study: cross-sectional 4) setting: occupational division of University of Sao Paulo 5) participants: 6,587 employees aged 20 to 69 years-old classified according three occupational grades (non-skilled, both manual and non-manual jobs; technical; faculty). 6) …

Satisfaction Of Orthognathic Surgical Patients In A Malaysian Population, K. K. Siow, S. T. Ong, C. B. Lian, W.C. Ngeow

Wei Cheong Ngeow

Thirty-one patients treated at the Faculty of Dentistry, University of Malaya, were assessed for their satisfaction following orthognathic surgery. The female to male ratio was 22:9 with an age range of 17 to 36. Almost all patients (97%) listed appearance as one of their rationales for surgery. More males (78%) than females (59%) wanted functional improvement, while more females (91%) than males (33%) hoped for improvement in self-confidence. All patients reported esthetic improvement while 68% each reported improvement in mastication and self-confidence. Slightly more than half (52%) chose esthetic improvement as the single most important factor resulting in satisfaction. Almost …

Orthognathic Surgery In The University Of Malaya, W.C. Ngeow, S. T. Ong, K. K. Siow, C. B. Ian

Wei Cheong Ngeow

This is the first review on orthognathic surgery in Malaysia. The records of a total of 84 patients seen between 1977 and 1999 in the Department of Oral and Maxillofacial Surgery of the Faculty of Dentistry, University of Malaya were analysed. Skeletal III deformity formed 85% of the sample with a female dominance of 2 to 1. The patients' age ranged from 17 to 36 years, with a mean of 25.3 years. The common surgical techniques used were combined bilateral sagittal split and Le Fort I osteotomy. The predominant ethnic group was Chinese (n=58, 69%); followed by Malay (n=14, 17%) …

Cutting Edge: Persistent Viral Infection Prevents Tolerance Induction And Escapes Immune Control Following Cd28/Cd40 Blockade-Based Regimen, Thandi M. Onami, M. A. Williams, A. B. Adams, M. M. Durham, T. C. Pearson, R. Ahmed, C. P. Larsen

Thandi M. Onami

A continuing concern with CD28 and/or CD40 blockade-based strategies to induce tolerance and mixed chimerism is their potential to disrupt protective immunity to preexisting infections. In this report, we find that preexisting persistent infection with lymphocytic choriomeningitis virus (LCMV) clone 13 prevents the induction of tolerance, mixed chimerism, and donor-reactive T cell deletion. Mice continue to be refractory to tolerance induction even after viremia has been resolved and virus is present only at very low levels in peripheral tissues. Conversely, we find that the full tolerance regimen, or costimulation blockade alone, specifically inhibits already ongoing antiviral immune responses, leading to …

Short Communication: Relationship Between Body Growth And Mammary Development In Dairy Heifers, L F. Silva, M J. Vandehaar, Brian K. Whitlock, R P. Radcliff, H A. Tucker

Brian K Whitlock, PhD, DVM, DACT

Our objective was to determine if prepubertal rate of body weight (BW) gain, independent of diet, was related to mammary development of dairy heifers. Data from two studies recently conducted at Michigan State University were used to identify factors, within a dietary treatment group, that would account for variation in first lactation milk production or amount of mammary parenchymal DNA at the time of puberty. Factors analyzed for variation in milk production during first lactation were: postpartum BW, prepubertal BW gain, gestational BW gain, postpartum BW gain, body condition score (BCS) at breeding, and BCS at calving. Factors analyzed for …

A Bayesian Analysis Involving Colonic Crypt Structure And Coordinated Response To Carcinogens Incorporating Missing Crypts, Jeffrey S. Morris, Naisyin Wang, Joanne R. Lupton, Robert S. Chapkin, Nancy D. Turner, Mee-Young Hong, Raymond J. Carroll

Jeffrey S. Morris

This paper is concerned with modeling the architecture of colonic crypts and the implications of this modeling for understanding possible coordinated response of carcinogen–induced DNA damage between various regions of the colon. The methods we develop to address these two issues are applied to a particular important example in colon carcinogenesis. We cast the problem as an unusual and not previously studied hierarchical mixed-effects model characterized by completely missing covariates in units at a structurally base level, except for some randomly selected units. Information concerning the missing covariates is available through certain known ordering constraints and surrogate measures. Our methods …

Molecular Cloning And Characterization Of A Novel Mouse Macrophage C-Type Lectin, Mmgl2, Which Has A Distinct Carbohydrate Specificity From Mmgl1, Thandi M. Onami, M. Tsuiji, M. Fujimori, Y. Ohashi, N. Higashi, S. M. Hendrick, T. Irimura

Thandi M. Onami

A novel mouse macrophage galactose-type C-type lectin 2 (mMGL2) was identified by BLAST analysis of expressed sequence tags. The sequence of mMGL2 is highly homologous to the mMGL, which should now be called mMGL1. The open reading frame of mMGL2 contains a sequence corresponding to a type II transmembrane protein with 332 amino acids having a single extracellular C-type lectin domain. The 3'-untranslated region included long terminal repeats of mouse early transposon. The Mgl2 gene was cloned from a 129/SvJ mouse genomic library and sequenced. The gene spans 7,136 base pairs and consists of 10 exons, which is similar to …

Generation Of Mice Deficient For Macrophage Galactose- And N-Acetylgalactosamine-Specific Lectin: Limited Role In Lymphoid And Erythroid Homeostasis And Evidence For Multiple Lectins, Thandi M. Onami, M. Y. Lin, D. M. Page, S. A. Reynolds, C. D. Katayama, J. D. Marth, T. Irimura, A. Varki, N. Varki, S. M. Hedrick

Thandi M. Onami

Macrophage receptors function in pattern recognition for the induction of innate immunity, in cellular communication to mediate the regulation of adaptive immune responses, and in the clearance of some glycosylated cells or glycoproteins from the circulation. They also function in homeostasis by initiating the engulfment of apoptotic cells. Evidence has suggested that macrophage receptors function to recognize cells that are destined for programmed cell death but not yet overtly apoptotic. We have examined the function of a macrophage receptor specific for unsialylated glycoproteins, known as the mouse macrophage galactose- and N-acetylgalactosamine-specific lectin (mMGL) (Ii et al., J. Biol. Chem. 265:11295-11298, …

How Cigarette Advertising Works: Rich Imagery And Poor Information, Richard W. Pollay

Richard W. Pollay

No abstract provided.

Malignancy In Oral Lichen Planus: A Review Of A Group From The Malaysian Population, H. B. Yaacob, P. L. Tan, W.C. Ngeow

Wei Cheong Ngeow

The objective of this study was to determine the socio-demography (age, race and gender) of a group of Malaysian patients who were diagnosed as suffering from oral lichen planus (OLP). The occurrence of malignancy was also investigated. A total of 77 clinical and biopsy records of patients with OLP were studied. Females were affected more than males, with the female to male ratio being 2:1. Middle-aged Indian and Chinese females tend to be affected by OLP when compared with the rest of the population. Only 19 patients returned for further follow-up. One adult Indian female with a six-year history of …

Effect Of Dietary Protein On Prepubertal Mammary Development In Rapidly Growing Dairy Heifers, Brian K. Whitlock, M J. Vandehaar, L F. Silva, H A. Tucker

Brian K Whitlock, PhD, DVM, DACT

The objective was to determine whether increased dietary protein would enhance mammary development in prepubertal heifers fed for rapid body growth (1.2 kg/d). Fifty-four Holstein heifers (weighing approximately 134 kg) were assigned to one of three treatments. Heifers were fed a total mixed ration with metabolizable energy at 2.85 Mcal/kg and metabolizable protein at low, standard, or high concentrations (37, 41, or 44 g/Mcal of metabolizable energy, respectively) from 3.5 mo of age until slaughter at approximately 46 d after puberty. Heifers fed low, standard, and high protein gained 1130, 1170, and 1180 g/d, respectively. Dietary protein did not affect …

Dynamic Regulation Of T Cell Immunity By Cd43, Thandi M. Onami, L. E. Harrington, M. A. Williams, M. Galvan, C. P. Larsen, T. C. Pearson, N. Manjunath, L. G. Baum, B. D. Pearce, R. Ahmed

Thandi M. Onami

During a viral response, Ag-specific effector T cells show dramatically increased binding by the mAb 1B11 and the lectin peanut agglutinin (PNA). We investigated the contribution of CD43 expression to 1B11 and PNA binding as well as its role in generation and maintenance of a CD8 T cell response. Analysis of CD43(-/-) mice revealed no increased 1B11 binding and reduced PNA binding on virus-specific CD8 T cells from -/- mice compared with +/+ mice. Furthermore, we examined the role of CD43 in the kinetics of an immune response. We show that CD43 expression modestly effects generation of a primary virus-specific …

Dengue And Hurricane Reconstruction - Text 2002, Frank Cortez Flores

Frank Cortez Flores

Unrelenting rains and savage winds, which accompany hurricanes, produce devastating mudslides and sustained flooding. In the wake of hurricanes, thousands of inhabitants face the plight of a greatly diminished capacity to go about their daily lives as a result of destroyed or severely-damaged homes, deteriorated living conditions, and increased health risks. Hurricanes inevitably aggravate the frail health of an already vulnerable segment of the population living both in and outside its destructive path. Repeated epidemics of dengue and dengue hemorrhagic fever afflicting millions of individuals occur annually in tropical and subtropical areas of the world, including The Caribbean and Central …

The Aging And Dying Processes And The Health Of Older Adults, Paula Diehr

Paula Diehr

It is difficult to distinguish changes in health due to aging from those related to dying, because the two processes are highly related. Some potentially treatable conditions may mistakenly be dismissed as due to old age. The goal of this article was to examine the relationships of aging and of dying to changes in 10 health-related variables: self-rated health, depression, ADLs, IADLs, minimental state examination, body mass index, blocks walked per week, bed days, hospitalization, and walking speed (all coded so that higher values were better). We used longitudinal data from the Cardiovascular Health Study to estimate the changes in …

Language Plasticity Revealed By Electroencephalogram Mapping, Armando F. Rocha, Flávia B. Foz

Armando F Rocha

Reasoning is the result of the computations made by intelligent systems, for instance those in the brain. It is not an abstract concept because calculations performed by computations are very concrete transactions among the different central processing unit components. Entropy measurements are proposed here to disclose the plasticity of the cerebral processing associated with language comprehension in video game playing. It is also assumed that entropy may be evaluated from the correlation coefficients obtained for the game event-related activity calculated for the different electroencephalogram derivations in the 10/20 system. The brain mapping derived from these entropy measurements clearly demonstrates the …

Targeting Of Asian Americans And Pacific Islanders By The Tobacco Industry: Results From The Minnesota Tobacco Document Depository, Richard W. Pollay

Richard W. Pollay

No abstract provided.

Galactose-Binding Lectin From The Seeds Of Champedak (Artocarpus Integer): Sequences Of Its Subunits And Interactions With Human Serum O-Glycosylated Glycoproteins, Onn Haji Hashim

Onn Haji Hashim

Our group has previously reported the isolation, partial characterisation, and application of a Galbeta1-3GalNAc- and IgA1-reactive lectin from the seeds of champedak (Artocarpus integer). In the present study, we have subjected the purified lectin to reverse-phase high performance liquid chromatography and sequenced its subunits. Determination of the N-terminal sequence of the first 47 residues of the large subunit demonstrated at least 95% homology to the N-terminal sequence of the alpha chains of a few other galactose-binding Artocarpus lectins, The two smaller subunits of the lectin, each comprised of 21 amino acid residues, demonstrated minor sequence variability. Their sequences were generally …

Response Decision Processes And Externalizing Behavior Problems In Adolescents, Reid Griffith Fontaine, Virginia Salzer Burks, Kenneth A. Dodge

Reid G. Fontaine

Externalizing behavior problems of 124 adolescents were assessed across Grades 7–11. In Grade 9, participants were also assessed across social-cognitive domains after imagining themselves as the object of provocations portrayed in six videotaped vignettes. Participants responded to vignette-based questions representing multiple processes of the response decision step of social information processing. Phase 1 of our investigation supported a two-factor model of the response evaluation process of response decision (response valuation and outcome expectancy). Phase 2 showed significant relations between the set of these response decision processes, as well as response selection, measured in Grade 9 and (a) externalizing behavior in …

Migraine And Coronary Heart Disease In Women And Men, Paulo A. Lotufo

Paulo A Lotufo

Objective.—We evaluated migraine as an independent risk factor for subsequent coronary heart disease (CHD) events among women in the Women’s Health Study (WHS) and men in the Physicians’ Health Study (PHS). Background.—Although several studies have suggested that migraine is associated with increased risk of stroke, there are few and conflicting data on whether migraine predicts risk of future CHD events. Methods.—The WHS is an ongoing randomized, double-blind, placebo-controlled trial of low-dose aspirin and vitamin E in the primary prevention of cardiovascular disease and cancer in 39,876 women health professionals aged 45 years in 1993, and the PHS is a completed …

Epidemologia Das Doenças Cardiovasculares No Brasil [Portuguese], Paulo A. Lotufo

Paulo A Lotufo

No abstract provided.

The Importance Of The Normality Assumption In Large Public Health Data Sets, Paula Diehr, Thomas Lumley

Paula Diehr

It is widely but incorrectly believed that the t-test and linear regression are valid only for Normally distributed outcomes. The t-test and linear regression compare the mean of an outcome variable for different subjects. While these are valid even in very small samples if the outcome variable is Normally distributed, their major usefulness comes from the fact that in large samples they are valid for any distribution. We demonstrate this validity by simulation in extremely non-Normal data. We discuss situations in which in other methods such as the Wilcoxon rank sum test and ordinal logistic regression (proportional odds model) have …

Weight-Modification Trials In Older Adults: What Should The Outcome Measure Be?, Paula Diehr

Paula Diehr

BACKGROUND: Overweight older adults are often counseled to lose weight, even though there is little evidence of excess mortality in that age group. Overweight and underweight may be more associated with health status than with mortality, but few clinical trials of any kind have been based on maximizing years of healthy life (YHL), as opposed to years of life (YOL). OBJECTIVE: This paper examines the relationship of body mass index (BMI) to both YHL and YOL. Results were used to determine whether clinical trials of weight-modification based on improving YHL would be more powerful than studies based on survival. DESIGN: …

Strategies Used By Families To Simplify Tasks For Individuals With Alzheimer's Disease And Related Disorders: Psychometric Analysis Of The Task Management Strategy Index, Laura Gitlin, Lorraine Winter, Sandy Schinfeld, Marie Dennis, Mary A. Corcoran, Walter Hauck

Mary A Corcoran

No abstract provided.

What’S Therapeutic About The Therapeutic Milieu?, Sandra Thomas, Mona Shattell, Tracey Martin

Mona Shattell

While the milieu of an inpatient facility is considered a treatment modality, extant literature focuses on the staff’s role in creating the milieu rather than the patient’s perception of it. Not since Goffman’s Asylums (1961) has there been an in-depth examination of the phenomenal world of the hospitalized psychiatric patient. In this study, eight inpatients (ages 23 to 58) on the acute psychiatric unit of a metropolitan general hospital participated in phenomenological interviews about their experience of the environment. The essential meaning of the hospital was refuge from selfdestructiveness. Prominent aspects of patients’ experience within the place of refuge were …

Variability Of Placental Expression Of Cyclin E Low Molecular Weight Variants, A Bukovsky, Maria Cekanova Ms, Rndr, Phd, Mr Caudle, J Wimalasena, Js Foster, Ja Keenan, Rf Elder

Maria Cekanova MS, RNDr, PhD

No abstract provided.

Differentiation And Treatment Of Anemia In Hiv Disease, Kenneth D. Phillips, M Groer

Kenneth D. Phillips

Anemia is a frequent complication of HIV disease that contributes to decreased quality of life and increased morbidity and mortality. The three major categories of anemia in HIV disease are anemia due to impaired red blood cell production, anemia due to increased red blood cell destruction, and anemia due to increased red blood cell loss. Although anemia of chronic illness is the most common type of anemia in HIV disease, other classifications of anemia may be encountered. Understanding the pathophysiology of anemia and laboratory tests that are frequently used to establish the differential diagnosis of anemia helps to ensure that …

Incidence And Correlates Of Violence Among Hiv-Infected Women At Risk For Pregnancy In The Southeastern United States, R.L. Sowell, Kenneth D. Phillips, B. Seals, C. Murdaugh, C. Rush

Kenneth D. Phillips

To identify the incidence and correlates of physical and sexual violence among HIV-infected women at risk for pregnancy, a cross-sectional examination was conducted within a longitudinal study of reproductive decision making. Participants consisted of 275 HIVinfected women 17 to 49 years of age (mean = 30.1 years).Women were predominantly African American (87%) and single (82%), with annual incomes of $10,000 or less (66%). Overall, 68% of the women reported experiencing lifetime physical and/or sexual violence. Before becoming HIV infected, 65% of the women reported having been physically or sexually abused. After HIV diagnosis, 33% of the women reported experiencing physical …

Age Differences In Anger Frequency, Intensity, And Expression, Sandra Thomas

Sandra Thomas

BACKGROUND: Although research consistently indicates harmful effects of mismanaged anger, little attention has been given to age differences in the experience and expression of this emotion. It is plausible that, with age and experience, people have less intense anger or learn to manage it more constructively.

OBJECTIVE: The purpose of this project was to examine age differences in anger frequency, intensity, and expression in a nonclinical sample of students, faculty, and staff who participated in a health fair at a large southeastern university.

STUDY DESIGN: This descriptive study involved a predominantly white sample, ranging in age from 18 to 76 …

What's Therapeutic About The Therapeutic Milieu?, Sandra Thomas, M. Shattell, T. Martin

Sandra Thomas

While the milieu of an inpatient facility is considered a treatment modality, extant literature focuses on the staff's role in creating the milieu rather than the patient's perception of it. Not since Goffman's Asylums (1961) has there been an in-depth examination of the phenomenal world of the hospitalized psychiatric patient. In this study, eight inpatients (ages 23 to 58) on the acute psychiatric unit of a metropolitan general hospital participated in phenomenological interviews about their experience of the environment. The essential meaning of the hospital was refuge from self-destructiveness. Prominent aspects of patients' experience within the place of refuge were …

A Phenomenological Study Of The Experience Of The Spouse Of A Heart Transplant Recipient, A.H. Mccurry, Sandra Thomas

Sandra Thomas

In this phenomenological study, in-depth interviews were used to obtain a description of spouses’ experiences in heart transplantation. Thematic analysis of the transcripts revealed four major, interrelated themes: death-life, vigilance, change, and gift. The experience was contextualized by the existential grounds of time and other people. Findings suggested that the changes inherent in the transplant experience have not been fully described in previous studies. The theme of death-life was dominant and pervasive in all interviews. As the threat of their husbands’ deaths became less prominent, wives reported difficulty letting go of their vigilance. Although the most outstanding gift was that …