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Full-Text Articles in Medicine and Health Sciences
Toxoplasma Gondii Induces Granulocyte Colony-Stimulating Factor And Granulocyte-Macrophage Colony-Stimulating Factor Secretion By Human Fibroblasts: Implications For Neutrophil Apoptosis, Jacqueline Y. Channon, Kristin A. Miselis, Laurie A. Minns, Chaitali Dutta, Lloyd H. Kasper
Toxoplasma Gondii Induces Granulocyte Colony-Stimulating Factor And Granulocyte-Macrophage Colony-Stimulating Factor Secretion By Human Fibroblasts: Implications For Neutrophil Apoptosis, Jacqueline Y. Channon, Kristin A. Miselis, Laurie A. Minns, Chaitali Dutta, Lloyd H. Kasper
Dartmouth Scholarship
Human neutrophils are rescued from apoptosis following incubation with once-washed, fibroblast-derived Toxoplasma gondii tachyzoites. Both infected and uninfected neutrophils are rescued, implicating a soluble mediator. In this study we investigated the origin and identity of this soluble mediator. Neutrophils were incubated either with purified tachyzoites or with conditioned medium derived from T. gondii-infected human fibroblasts. Conditioned medium was found to be a potent stimulus that delayed neutrophil apoptosis up to 72 h, whereas purified and extensively washed tachyzoites had no effect. Delayed apoptosis correlated with up-regulation of the neutrophil antiapoptotic protein, Mcl-1, and the neutrophil interleukin 3 receptor alpha subunit …
The Signaling Pathway Of Oxysterol Induced Apoptosis In Chinese Hamster Ovary (Cho)-K1 Cells., Lin Yang
The Signaling Pathway Of Oxysterol Induced Apoptosis In Chinese Hamster Ovary (Cho)-K1 Cells., Lin Yang
Electronic Theses and Dissertations
Apoptosis, a form of genetically programmed cell death, plays a key role in regulation of cellularity of the arterial wall. During atherogenesis, improper apoptosis may cause abnormalities of arterial morphogenesis, wall structural stability, and metabolisms. It has been well established that vascular cells undergo apoptosis after uptake of oxidized low-density lipoprotein (oxLDL). Thus, an analysis of the signaling pathway of apoptotic induction by oxLDL is of value in understanding the development of atherosclerotic plaque. In order to elucidate the signaling pathway of apoptosis induced by oxLDL, we have used Chinese hamster ovary (CHO)-K1 cells treated with a potent oxysterol, 25-hydroxycholesterol …
Method For Controlling Cell Necrosis Or Apoptosis, Elaine L. Jacobson, Myron Jacobson
Method For Controlling Cell Necrosis Or Apoptosis, Elaine L. Jacobson, Myron Jacobson
Graduate Center for Nutritional Sciences Faculty Patents
The invention relates to the manipulation of enzymatic pathways, such as poly (ADP-ribose) polymerase pathways, which are dependent upon NAD as a substrate. By administering pro-NAD compounds, cell death caused by necrosis and/or apoptosis can be reduced. Further, by inhibiting one or more of these enzymes, the process of cell death can be accelerated, in conditions such as cancer, where acceleration of cellular necrosis and/or apoptosis is desired. Various inhibitors are described.
Ube1l Is A Retinoid Target That Triggers Pml/Rarα Degradation And Apoptosis In Acute Promyelocytic Leukemia, Sutisak Kitareewan, Ian Pitha-Rowe, David Sekula, Christopher H. Lowrey, Michael J. Nemeth, Todd R. Golub, Sarah J. Freemantle, Ethan Dmitrovsky
Ube1l Is A Retinoid Target That Triggers Pml/Rarα Degradation And Apoptosis In Acute Promyelocytic Leukemia, Sutisak Kitareewan, Ian Pitha-Rowe, David Sekula, Christopher H. Lowrey, Michael J. Nemeth, Todd R. Golub, Sarah J. Freemantle, Ethan Dmitrovsky
Dartmouth Scholarship
All-trans-retinoic acid (RA) treatment induces remissions in acute promyelocytic leukemia (APL) cases expressing the t(15;17) product, promyelocytic leukemia (PML)/RA receptor α (RARα). Microarray analyses previously revealed induction of UBE1L (ubiquitin-activating enzyme E1-like) after RA treatment of NB4 APL cells. We report here that this occurs within 3 h in RA-sensitive but not RA-resistant APL cells, implicating UBE1L as a direct retinoid target. A 1.3-kb fragment of the UBE1L promoter was capable of mediating transcriptional response to RA in a retinoid receptor-selective manner. PML/RARα, a repressor of RA target genes, abolished this UBE1L promoter activity. A hallmark of …
Siva-1 Binds To And Inhibits Bcl-Xl-Mediated Protection Against Uv Radiation-Induced Apoptosis, Li Xue, Fei Chu, Yuan Cheng, Xiangjie Sun, Alip Borthakur, Manjunath Ramarao, Pramod Pandey, Mei Wu, Stuart F. Schlossman, Kanteti V. S. Prasad
Siva-1 Binds To And Inhibits Bcl-Xl-Mediated Protection Against Uv Radiation-Induced Apoptosis, Li Xue, Fei Chu, Yuan Cheng, Xiangjie Sun, Alip Borthakur, Manjunath Ramarao, Pramod Pandey, Mei Wu, Stuart F. Schlossman, Kanteti V. S. Prasad
Clinical & Translational Sciences
We previously cloned Siva-1 by using the cytoplasmic tail of CD27, a member of the tumor necrosis factor receptor family, as the bait in the yeast two-hybrid system. The Siva gene is organized into four exons that code for the predominant full-length Siva-1 transcript, whereas its alternate splice form, Siva-2, lacks exon 2 coding sequence. Various groups have demonstrated a role for Siva-1 in several apoptotic pathways. Interestingly, the proapoptotic properties of Siva-1 are lacking in Siva-2. The fact that Siva-1 is partly localized to mitochondria despite the absence of any mitochondrial targeting signal, it harbors a 20-aa-long putative amphipathic …