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Survival Versus Years Of Healthy Life; Which Is More Powerful As A Study Outcome?, Paula Diehr
Survival Versus Years Of Healthy Life; Which Is More Powerful As A Study Outcome?, Paula Diehr
Paula Diehr
Studies of interventions that are intended to improve patients' health are often evaluated with survival as the primary outcome, even when a measure adjusted for quality of survival, such as years of healthy life (YHL), would seem more appropriate. The purpose of this article is to determine whether studies based on survival are more or less powerful than studies based on YHL in clinical trials where either measure might be appropriate. We used data from the Cardiovascular Health Study (CHS) to estimate the sample size that would be needed in studies of 156 different health conditions, for the two outcome …