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Proliferating Cell Nuclear Antigen (Pcna) And P53 In Epithelial Dysplasia And Squamous Cell Carcinoma Of Oral Mucosa - A Marker For Poor Tumor Differentiation, Increasing Nuclear Atypia And Invasiveness?, Lan H. A., Rosnah Binti Zain, Saitoh M., Muramatsu Y., Shrestha P., Mori M.
Proliferating Cell Nuclear Antigen (Pcna) And P53 In Epithelial Dysplasia And Squamous Cell Carcinoma Of Oral Mucosa - A Marker For Poor Tumor Differentiation, Increasing Nuclear Atypia And Invasiveness?, Lan H. A., Rosnah Binti Zain, Saitoh M., Muramatsu Y., Shrestha P., Mori M.
Prof. Dr. Rosnah Binti Zain
The immunohistochemical expression of proliferating cell nuclear antigen (PCNA) and p53 was investigated in 9 cases of epithelial dysplasia and 38 cases of squamous cell carcinoma of the oral cavity. The intensity of immunoreactivity for each marker was assessed using a semiquantitative grading system, and was correlated with tumor differentiation, nuclear atypia and the patterns of invasive margins in the underlying connective tissue. PCNA expression, in dysplastic epithelium, was observed in the suprabasal and lower spinous layers; and the labeling grade and intensity of staining increased along the degree of cellular atypia. In 2 cases of dysplasia, weak positive immunoreactivity …