Medicine and Health Sciences Commons^™

Patient Navigational Tool Increase Resource Use In A Latino Population, Kimberly Burrus

Student Scholarly Projects

Practice Problem: The practice problem is a patient navigation tool in a mobile health clinic for the Latino population to help improve utilization of resources within Daviess County, Indiana, and improve overall health literacy and health of those populations?

PICOT: The PICOT question that guided this project was: In a mobile health clinic serving Latino populations (P), does a navigation tool (I) compared to current practices (C) improve utilization of services (O) within a 12-week timeframe (T)?

Evidence: The evidence that guided this project showed patients with limited English proficiency, immigrant families have a disparity of health literacy, and an …

Design, Construction, And Testing Of Recombinant Dna-Based Vaccines For Protection Against Salmonella Enterica Subspecies Enterica Serovar Javiana, Ashley Edwards

LSU Doctoral Dissertations

In the United States, Salmonella Javiana is among the top 5 most common nontyphoidal Salmonella serotypes, with a 325% increase in infection rate since 1970. Globally, nontyphoidal Salmonella leads to approximately 93.8 million illnesses and 155,000 deaths annually, with disproportionate impacts in developing countries. In the United States alone, these infections lead to over $4 billion in costs, the majority of which are attributed to those expenses incurred from mortalities. The zoonotic nature of nontyphoidal Salmonellae and their ability to survive on and within vegetation mean huge economic burden potential for various agricultural industries as well, especially since some of …

Prevalence And Beliefs Associated With Vaccine Hesitancy Among Muslim-Americans, Marina Ali

Health and Kinesiology Theses

Background. Vaccine hesitancy hinders the eradication of preventable illnesses. Furthermore, there are gaps in public health research on vaccine hesitancy among Muslims in heterogenous societies.

Objective. This study aimed to determine whether socioeconomic demographics, political beliefs and trust in public institutions were associated with vaccine hesitancy beliefs. Additionally, two models were applied to determine which factors had the strongest influence in rejecting vaccines.

Method. Participants were recruited through Facebook group posts. Seventy-three responses were received. Sixty-three responses met the inclusion criteria and were included in the final analysis. Participants rated their opinions on political beliefs, religious practices, trust in institutions …

Undergraduate Major And Covid-19 Vaccination Rates Among University Of South Carolina Students, Rebecca Stoltz

Senior Theses

The COVID-19 pandemic brought new vaccines to the forefront of public attention, and with it came a wide array of different opinions. The University of South Carolina did not require students to receive a COVID vaccine, so the decision was left entirely to the individual. Many of my peers have shown support or voiced opposition to the vaccine, and I noticed that those who opposed tended to fall within certain major categories. This study seeks to determine whether a correlation exists between undergraduate major groups and vaccination status, and to gather student attitudes and concerns surrounding vaccines. Among 172 survey …

Clinical Vaccination Education Guideline For The African American Community, Margaret Chinedum Nwoji

Walden Dissertations and Doctoral Studies

AbstractVaccination hesitancy is high among African Americans and other people of color. The practice gap addressed in this project was the lack of a culturally sensitive clinical guideline for vaccination education relevant to the African American community. The practice-focused question was answered by developing an evidence-based Clinical Vaccination Education Guideline for the African American Community (CVEGAAC) that was validated by a group of four content experts using the Appraisal of Guidelines, Research, and Evaluation tool. The content experts scored each of the domains above 90%, implying that the CVEGAAC is of high quality and ready for implementation. The end users …

Influences On Influenza Vaccine Uptake Among Older Lebanese Adults, Doha D'Agostini

Walden Dissertations and Doctoral Studies

Influenza is a viral infection that is globally transmitted and that increases the risk for infectious diseases, hospitalization, and morbidity and mortality, especially among the older adult population. Although influenza vaccines are recommended in several countries, influenza vaccine hesitancy remains a challenge. In Lebanon, there is minimal research related to older adults’ attitudes and perceptions associated with influenza vaccination. To explore older Lebanese adults’ vaccination experiences and perceptions of the factors that affect their influenza vaccine uptake, a qualitative investigation was conducted. The theory of planned behaviors served as the theoretical framework for the study. A thematic analysis was conducted …

Influences On Influenza Vaccine Uptake Among Older Lebanese Adults, Doha D'Agostini

Walden Dissertations and Doctoral Studies

Influenza is a viral infection that is globally transmitted and that increases the risk for infectious diseases, hospitalization, and morbidity and mortality, especially among the older adult population. Although influenza vaccines are recommended in several countries, influenza vaccine hesitancy remains a challenge. In Lebanon, there is minimal research related to older adults’ attitudes and perceptions associated with influenza vaccination. To explore older Lebanese adults’ vaccination experiences and perceptions of the factors that affect their influenza vaccine uptake, a qualitative investigation was conducted. The theory of planned behaviors served as the theoretical framework for the study. A thematic analysis was conducted …

Factors Influencing Vaccination Rates In Children Under Two In Southeast Kansas, Danielle Bennett

Doctor of Nursing Practice Scholarly Project

Introduction

A large Federally Qualified Health Center (FQHC) in Southeast Kansas has a 37% compliance of children completing the recommended combo 10 primary vaccination series before their second birthday. An additional 20% of children would be compliant if the flu vaccine was excluded, raising the compliance rate to 57%. This is still below the national average of 68-75%, leaving many children in Southeast Kansas and northeast Oklahoma unprotected from preventable childhood diseases.

Purpose

The purpose of this scholarly project was to identify barriers to vaccination, including vaccine hesitancy and socioeconomic barriers affecting completion of the primary vaccine series, or combo …

Religious And Cultural Considerations In Nigeria Regarding The Low Vaccination Rates For The Oral Polio Vaccine, Allison Luann Welz

Undergraduate Honors Thesis Collection

When the polio vaccine was developed in the 1950s, the healthcare field saw the eradication of polio happening by the turn of the 21st century. However, in 2022 there are still countries with endemic strains of polio, with Nigeria only recently being taken off of this list in 2020. This paper focuses on synthesizing research about the initial oral polio vaccine (OPV) efforts in 2002 Nigeria to improved efforts in the 2010s. Nigeria is widely known for boycotting the vaccine and implementing extensive educational programming attempts to remedy the situation. By looking at various cultural and religious factors that caused …

Improving Vaccination Rates In Pediatric Primary Care, Lauren E. Osbeck

Doctoral Dissertations

Objectives: In a small, rural pediatric primary care clinic, the effectiveness of electronic patient portal reminders were evaluated at improving vaccination rates for school required immunizations.

Methods: A quality improvement project was initiated utilizing The Social Ecological Model. All pediatric patients were sent reminders who were under-immunized. This QI project evaluated the effectiveness of vaccine reminders on the improvement of immunization rates in the clinic

Results: Total number of fully-vaccinated patients within the practice improved (2%) and patients under-immunized decreased by 1%. 87 immunizations were given to patients were given to patients who were under-immunized and an average of 10% …

Nursing Students’ Perspectives On The Covid-19 Vaccines: Moderna, Pfizer, And Johnson And Johnson, Savannah M. Workman

Honors College Theses

There are very few things that everyone in the world shares in common, but there is one thing that has recently plagued our entire world and has impacted each person’s life. The first case of COVID-19 occurred in the United States in January of 2020. In the United States during March of 2020, life as we knew it changed. Restrictions were put in place, schools closed, food and supply chain shortages occurred, travel was banned, and we were warned to stay away from others as they could be symptomatically or asymptomatically carrying the novel coronavirus. Since the time of quarantine …

Covid-19 Vaccine Uptake Among College Students, Erin Hoening, Elizabeth Morse, David Phillippi, Krystal Huesmann

DNP Scholarly Projects

Background: Public health strategies to improve COVID-19 vaccine uptake among college students living in residential communities varied, some universities opted to mandate COVID-19 vaccines while other universities opted to promote and influence the choice for vaccination.

Purpose: This descriptive, cross-sectional study examined the voluntary uptake of COVID-19 vaccines among residential students on a college campus in the southeastern U.S. that elected an evidence-driven health promotion strategy that included strong health promotion messaging coupled with coordinated efforts to make the vaccine accessible and appealing to students on campus.

Methods: Analysis of vaccine uptake was derived from campus electronic health records during …

Liposomal Technologies To Improve Gene Delivery, David Nardo Padron

Theses and Dissertations--Pharmacy

Lipid based nanoparticles (LBNs) are used in myriad applications in medicine from small molecule drug delivery to mRNA vaccines. A major contributing factor to the development of the field has been the ongoing development of novel compounds that retain the functionality of natural lipids but expand upon them through inclusion of functional moieties that can be applied to specific scientific and biomedical questions. In the body of this dissertation, an extensive overview of LBNs is provided, focusing primarily on their use in immune modulation. The research presented herein begins with the synthesis of a novel class of lipids based on …

Gaps In Immunization Prevention In The State Of Ohio, Audrey Shaw

Walden Dissertations and Doctoral Studies

In the United States, the total cost for vaccine preventable diseases was $8.95 billion in 2015. The unvaccinated accounted for 80% of the total costs. This quantitative study was conducted to investigate the success and/or gaps in the implementation of the measles, mumps, and rubella (MMR) vaccine through the Vaccine for Children (VFC) Program by the Ohio Department of Health. General systems theory was chosen as a theoretical framework due to the complicated nature of the healthcare system. Healthcare is a complex system composed of multidisciplinary units that have their own structure and purpose that interact to accomplish the mission …

The Combination Of Tlr7/8 And Tlr4 Adjuvants In An Influenza Vaccine Produce Unique Antigen-Specific Adaptive Immunity And Protect Against Lethal Heterologous Influenza Challenge, Shelby Lynn Cole

Graduate Student Theses, Dissertations, & Professional Papers

Influenza virus infection is a global health concern resulting in death and illness each year, which disproportionally effects high-risk individuals. While there are several approved vaccines for seasonal influenza, there are some limitations to consider: current vaccines provide minimal cross protection against seasonally drifted influenza subtypes, influenza vaccine strains change each year, requiring timely manufacture of a new vaccine. Thus, vaccines capable of inducing a more robust and broadly protective immune response to multiple influenza subtypes remains a critical unmet need. Adjuvants and novel delivery systems are an interesting and promising avenue of exploration for enhancing and broadening seasonal influenza …

Understanding Vaccine-Induced Memory Responses To Develop The Next Generation Of Pertussis Vaccines, Kelly L. Weaver

Graduate Theses, Dissertations, and Problem Reports

Bordetella pertussis is a Gram-negative respiratory pathogen that can infect individuals of all ages and is notably responsible for infant fatalities. Pertussis (whooping cough) is a vaccine-preventable respiratory disease for which vaccines have been available in the United States since the 1940s. Whole cell pertussis vaccines kept incidence of pertussis under 5,000 cases per year, but were associated with reactogenicity issues. Following the introduction of less reactogenic acellular pertussis vaccines in the late 1990s, there have been noteworthy outbreaks of pertussis. For example, in 2012 there were over 50,000 reported cases of pertussis and 20 deaths in the U.S. The …

Parental Status As A Modifying Factor In Covid-19 Vaccination Status: A Mixed Methods Approach, Mackenzie Carter

All Master's Theses

Introduction: Vaccines are the best protection against COVID-19 and have been proven to be safe and effective. Parental efforts to protect their children by complying with or refusing pediatric vaccinations have previously been studied. However, the author found little research on how parental status affects the vaccination decisions for the parents. Using an explanatory sequential mixed-methods approach and the Health Belief Model, this study examines how parental status influences parental COVID-19 vaccination status. Methods: A local health department conducted a quantitative survey on COVID-19 vaccination attitudes and beliefs from September to October 2021. The COVID-19 vaccination status of parents of …

Influence Of Political Affiliation, Distrust Of Government And Pharmaceutical Companies On Hpv Vaccination Intentions And Uptake, Alyssa Andrea Martinez

Open Access Theses & Dissertations

Background and Significance: The Human Papillomavirus (HPV) is the most common sexually transmitted infection (STI) in the United States. Currently, approximately 79 million people in the United States are infected with HPV. The CDC estimates that there are nearly 31,500 cases of cancers caused by HPV each year in the United States. Cervical cancer is the most common HPV-related cancer and almost all cervical cancers are caused by a few strains of HPV. Research suggests that Latinx women residing in the U.S.-Mexico border may be at increased risk of contracting HPV types that cause cervical cancer. Although there is no …

Student Nurse Knowledge And Confidence Regarding Childhood Immunizations, Heather Westergard

Theses and Dissertations

Background: Immunization training is essential for nursing students. However, Brigham Young University's (BYU) Nursing Program lacks data regarding the current curriculum's effect on vaccination knowledge and confidence. Purpose: The purpose of the study is to explore BYU nursing students' knowledge and confidence regarding vaccinations. Methods: Nursing students at BYU in the second and fourth semesters were surveyed using pre-and post-test questionnaires designed to measure student nurses' knowledge of and confidence about immunizations. To help evaluate current curricula established immunization content was taught during both the public health course and pediatric course via direct instruction, assigned reading, quizzes, exams, lab, and …

Sars-Cov-2 (Covid-19), Matthew Baker

Nursing Student Class Projects (Formerly MSN)

SARS-CoV-2 (COVID-19) emerged in the fall of 2019 and impacted millions of people worldwide deeming it a global pandemic. The virus primarily impacts the respiratory system, but has shown to affect other organ systems such as the kidneys, heart, and brain. Respiratory failure leading to Adult Respiratory Distress Syndrome (ARDS) associated with COVID-19 requires ventilatory support and possibly prone therapy to increase lung volumes and prevention of atelectasis. There are several treatment modalities for mild and severe cases of COVID-19 that range from antivirals to vaccine development. COVID-19 is a complex virus that can vary from mild to severe cases …

Optimization Of Vaccine Supply Chains In Low- And Middle-Income Countries Utilizing Drones, Maximilian Kolter

Graduate Theses and Dissertations

Despite tremendous efforts from governments and humanitarian organizations, millions of children in low- and low-middle-income countries (LICs and LMICs) are still excluded from the benefits of immunization. The vaccine distribution in LICs and LMICs is challenging for several reasons, such as limited cold chain capacities, vaccine wastage, uncertain demand, and lack of access to immunization services. A promising avenue to address these issues is the utilization of drones for vaccine delivery. Drones can fly at high speed on direct paths and could enable on-demand deliveries to mitigate limited storage capacities. Further, their independence of road networks could allow them reaching …

Social/Cultural Factors In Preschool Immunizations, Mozambique, Kristine Gayle Bernabe

Walden Dissertations and Doctoral Studies

Immunizations are scientifically proven, effective global health interventions that prevent infectious diseases and save lives. Yet, in Mozambique at the national level, less than 65% of children are fully immunized, i.e., received all the basic/routine vaccinations. The overall purpose of the doctoral study was to conduct quantitative research examining the sociocultural factors that may impact childhood immunization status in the context of the social ecological model. The study examined the relationship between child’s gender, mother’s and her husband/partner’s educational level, household wealth index, religion, ethnicity/language, urban-rural residency, and province/region with the child’s full immunization status in Mozambique. Secondary analysis of …

Covid-19: Best Practices And The Way Forward, Juliana Nwauwa

Student Scholarly Projects

COVID-19 is a global health emergency that originated in Wuhan, China, in December 2019. It was declared a pandemic on March 11, 2020, and since then has affected more than 53,507,282 individuals and claimed the lives of more than 1,305,164 around the globe. It is a respiratory virus transmitted from person to person through airborne aerosols and droplets from infected individuals and direct contact with infected surfaces.

Numerous factors, such as socioeconomic status, population density, pre-existing health conditions, and lack of health insurance, have contributed to the disproportionate impact of COVID-19 among certain demographic groups. The COVID-19 impact ranges from …

Ethically Addressing Vaccine Hesitancy In Pediatric Populations, Tommie L. James Iii

Theses and Graduate Projects

Vaccines are highly regarded in the scientific and medical community for their efficacy in the prevention of disease; yet the prevalence of misinformation and mistrust surrounding vaccines is growing in communities around the world. Specifically observed in the United States (US) as an increase in vaccination exemption rates, this trend of vaccine hesitancy is leading to an increasing number of parents and caregivers to either refuse or delay vaccinations from the recommended schedule. As a result, an increasing number of outbreaks of diseases such as measles and pertussis, thought to be on the verge of elimination, have spiked. While health …

Vaccine Literacy Among Deaf Adult American Sign Language Users Of Hearing Parents, Casey Lee Peck

Undergraduate University Honors Capstones

Background: Communication barriers, the lack of proficiency in English, and poor communication with medical providers affect some Deaf people negatively in terms of health literacy. One contemporary controversial health literacy issue affecting Deaf people concerns vaccines. According to the literature, parents with higher health literacy are less likely to vaccinate their children as opposed to those parents with low health literacy (Veldwijk, van der Heide, Rademakers, Schuit, de Wit, Uiters & Lambooij 2015). Studies have shown that the majority of the deaf population have relatively low health literacy; however, vaccine literacy in the deaf population has not been investigated. Research …

Vaccine Confidence, Coverage, And Hesitancy Worldwide: A Literature Analysis Of Vaccine Hesitancy And Potential Causes Worldwide, Jordan Hammond

Senior Theses

Vaccines are one of the world’s most impactful medical therapies. They are cost-effective, successfully proven, and one of the quickest treatment options available today (Clark et al., 2016). They save millions of lives every year and have eliminated certain diseases on a national and international level. However, millions of people worldwide still remain unvaccinated. In developed nations, mainly The United States (U.S.) and the European countries, many of the unvaccinated are a result of rising vaccine hesitancy of parents in conjunction with the anti-vaccination movement. Vaccine hesitancy is defined as “a delay in acceptance or refusal of vaccines despite availability” …

Targeted Education For The Prevention Of Vaccine Refusal, Catina Lashawn Davis

Walden Dissertations and Doctoral Studies

Vaccinations are important factors in the eradication of most communicable diseases. Tetanus, diphtheria, and pertussis (Tdap) vaccine has been found to decrease the incidence and further spread of pertussis, and even nullify its existence, yet many postpartum mothers opt not to receive the vaccination even if eligible to do so. It was unknown whether clinical nursing staff at the project site had sufficient knowledge about Tdap vaccine to educate postpartum mothers to accept the vaccine. The practice-focused question explored whether an educational program and a toolkit implemented for nursing staff members on the postpartum nursing unit would improve Tdap vaccination …

Increasing Communication Through Improved Nursing Education: The Histories, Policies, And Manufacturing Process Of Vaccines, Alyssa R. Gruich

Senior Honors Theses and Projects

Increasing nursing education of vaccines is incredibly important when nurses are attempting to educate families on the risks and benefits of many childhood vaccines. Through learning about the history of major vaccines, vaccine policies and the vaccine manufacturing process, nurses may better understand how to communicate with families.

Effects Of The Influenza Vaccine On The Oral Cavity, Laura Sawires

Honors Undergraduate Theses

According to existing literature, there is a suggested correlation between certain vaccinations and oral cavity symptoms. Studies have shown that the Diphtheria, Tetanus, Acellular Pertusis, as well as Polio Vaccinations have an association with presented symptoms of bleeding gums, sores, ulcers, white spots in the mouth or on lips, and unpleasant breath odor. Although these symptoms may not occur simultaneously or directly after administration of the immunization, there has been supported evidence of correlation. Given the relevance of an association between vaccinations and orally manifested side effects, an investigation on the presence of such association with the widely administered flu …

Characterization Of Murine Breast Cancer Cell Lines For Anti-Cancer Vaccine, Haven N. Frazier

Biological Sciences Undergraduate Honors Theses

Breast cancer is the most commonly diagnosed cancer in women and the second leading cause of cancer death among women in the United States (1). While treatments involving radiation and chemotherapy currently exist, disease must be detected early in order for the treatments to be somewhat effective, and there is no effective treatment after metastasis occurs (2). Additionally, current therapies do not mitigate tumor immunosuppression. Decreasing the tumor-associated immunosuppressive conditions while activating antitumor immunity could prevent recurrence and metastasis, possibly leading to an effective treatment for cancer (3). Tumor cell vaccines could possibly address this issue and have become a …