Medicine and Health Sciences Commons^™

Investigating The Development Of Alcohol Tolerance In The Eskape Pathogens, Hannah Durkee

West Chester University Master’s Theses

Antiseptics and disinfectants are used globally to kill or inhibit the growth of bacteria to prevent infection. Considering the well-documented development of antibiotic resistance, the potential for evolved tolerance to alcohol-based antimicrobial agents raises concern. The ESKAPE bacterial pathogens (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter spp.) are a major cause of healthcare-associated mortality and present a threat to public health due to the progression of multi-drug resistance. We conducted an experiment to determine if the ESKAPE pathogens develop an increased tolerance to ethanol upon repeated exposure by selecting for survivors after a …

Targeting Of Mediator Kinases For Cancer Therapy And Resistance Prevention, Zachary Thomas Mack

Theses and Dissertations

Estrogen receptor (ER)-positive breast cancers make up 70% of all breast cancer incidences in the US. Cell cycle progression of ER-positive breast cancer is highly dependent on cyclin-dependent kinases (CDK) 4 and 6, the G1/S checkpoint kinases. Inhibitors of CDK4/6 have become a major addition to the clinical arsenal against ER-positive breast cancers. CDK4/6 inhibitor palbociclib (IBRANCETM) has been approved for the treatment of ER-positive breast cancers. However, palbociclib treatment eventually fails due to the development of resistance. Laboratory studies revealed several diverse mechanisms of palbociclib resistance, making universal re-sensitization difficult to achieve. However, prevention of the adaptive process that …

A Theoretical Framework For Understanding Breast Cancer Survivor's Post-Treatment Lived Experiences In An Educational Program: A Qualitative Data Analysis, Katherine Jinghua Lin

USF Tampa Graduate Theses and Dissertations

Breast cancer (BC) is the most prevalent type of cancer among women and the most common cancer diagnosis for all the population in the United States. Early screening and treatment for BC have improved the prognosis for breast cancer survivors (BCSs) and increased survival rate. Current evidence showed insufficient data related to BCSs’ post-treatment symptoms, coping issues, and availability and impact of educational and support programs associated with breast cancer survivorship.

The overall purpose of this qualitative data analysis research project is to explore and identify BCSs’ perceptions (post-treatment) of physical, cognitive, and psychological symptoms experienced, as well as perceptions …

Adaption, Retention, And Readaptation Strategies For Unfamiliar Leka (Lower-Extremity Knee Angles), Leea M. Perry

Honors Capstones

This capstone aimed to look into individuals’ abilities to adapt, retain, and readapt a newly-provided, typically over-exaggerated, goal knee angle for their right leg based upon feedback received and accuracy of examined gait pattern. Research was carried out using individuals aged 18-25, looking at the potential of “learning” per say, a new pattern for their rather instinctual previously formed habits for walking. Knee angle, both baseline and individuals’ attempts at goal angle, were measured with a knee brace worn throughout data collection. Participants for this study were blind in terms of what their goal LEKA (lower-extremity knee angle) was. The …

The Lived Experience Of Older Adults With Visual Impairments And Their Integration Into Social And Recreational Activities In The Long-Term Care Setting: A Phenomenological Study, Julie Ann Conboy Russo

Theses & Dissertations

The prevalence of vision loss in the elderly is high. Visual impairment in long-term care (LTC) settings may be a barrier to fully interacting in therapeutic recreational and social activities. Living with visual barriers may hamper safety (i.e., fear of falling and navigating in unfamiliar settings); cognitive ability; and participation in activities leading to isolation, depression, and loss of self-esteem. Decreased stimulation may affect one’s overall happiness and quality of life. A qualitative phenomenological design was followed to capture the lived experience of older adults with visual impairments living in LTC settings and their integration into social and recreational activities …

Molecular Mechanisms Of Antimicrobial Resistance In Multi-Drug Resistant Enterococci, Ayesha Khan

Dissertations & Theses (Open Access)

Antibiotic resistance is a major global public health threat. Enterococci are recalcitrant, nosocomial pathogens that can be intrinsically resistant to valuable antibiotics, like beta-lactams, or evolve resistance to all existing antimicrobials. The LiaFSR system regulates resistance to cell membrane (CM) stressors like daptomycin (DAP), a front-line drug for multi-drug resistant infections. DAP resistance (DAP-R) in E. faecalis is mediated by CM phospholipid alterations. Emergence of DAP-R often leads to b-lactam resensitization, a phenomenon called the seesaw effect. The molecular mechanism of DAP-R and the seesaw effect are unknown. Here we show that LiaX is a surface exposed protein whose C-terminal …

Home Assessment Modifications For Individuals With Autism Spectrum Disorder And Sensory Processing Disorder, Danielle Stelbasky

OTD Capstone Projects

Based off of the identified needs of individuals with Autism Spectrum Disorder, the goals of this project were to investigate and implement modifications in homes due to specific challenges these individuals face. Coinciding with Tucker's House Agency mission and vision, and incorporating the PEO model as a guideline, Tucker's House staff and EC student created projects to enhance occupational performance in individuals with ASD by reducing environmental barriers in their home.

Kinematic And Acoustic Adaptation To A Bite Block During Syllable Production, Allison Marie Barney

Theses and Dissertations

The purpose of the current study was to gain a better understanding of speech adaptation by examining kinematic and acoustic adaptation to bite block perturbation over time. Fifteen native American English speakers (7 female, 8 male) with no history of speech, language, or hearing deficits participated in the study. Custom bite blocks were created for speakers which created a 10mm interincisal gap when inserted. Speakers produced five repetitions of the sentence, I say ahraw /ərɑ/ (as part of a larger set) prior to bite block insertion, immediately following bite block insertion, 2-mintues post insertion, 4-minutes post insertion, 6-minutes post insertion, …

The Managemed Screening As A Tool For Discharge Planning, Manpreet Nijjar

OT Student Capstones

The ManageMed Screen was used as a tool for discharge planning from a post-acute rehab setting to reduce readmission rates. The goal was to identify barriers to medication adherence. Medication adherence is best explained as the extent to which patients follow the given instructions for prescribed medication.

Introducing Exercise And Home Safety Check To Decrease Falls In Older Adults, Alie Theresa Massicot-Gray

Walden Dissertations and Doctoral Studies

The lack of education related to causes of, complications from, and interventions for falls is associated with the high rate of falls and fall-related injuries in older adults (OAs) beginning at age 65. The purpose of this project was to develop a fall prevention program that included components of the Stopping Elderly Accidents Deaths & Injuries Algorithm to increase fall prevention awareness and reduce falls in OAs at one community senior center. The project practice question asked whether introducing a fall prevention program that focused on exercise and home safety checks to educate OAs could decrease the rate of falls. …

Investigating The Relationship Between Subcortical And Cortical Auditory Processing, Sonia Varma

Electronic Thesis and Dissertation Repository

The auditory system is highly integrative, with feedforward and feedback connections from periphery to cortex (and stages in between). In order to understand how the different levels of the human auditory system interact, it is necessary to simultaneously measure responses from multiple auditory levels. A novel stimulus was paired with electroencephalography (EEG) in 29 young, normal-hearing participants (17-34 years) to examine interactions among stages of the auditory pathway. Temporal regularity was manipulated by continuously accelerating and decelerating the rate of a click-train stimulus (i.e., ~3.5 Hz frequency modulation of the click rate). Adaptation of the brainstem (cochlear nucleus and inferior …

Changes In Psychological, Morphological, And Performance Characteristics In Preparation For A National Weightlifting Competition, Donald Marsh

Electronic Theses and Dissertations

The primary aim of this study was to examine the time course of change in muscle morphology and vertical jump performance in weightlifters preparing for a national competition. The secondary aim of this study is to examine how perceived recovery and stress state corresponds with alterations in training load leading up to competition. Eleven Olympic Training Site weightlifters completed a 4-week peaking phase for a national competition. Body mass, stress and recovery psychometric measures, and unloaded/loaded (20kg) squat jump height (SJH) were measured weekly and at the competition site. Vastus lateralis cross-sectional area (CSA), muscle thickness (MT) and pennation angle …

Phase Specific Changes In Rate Of Force Development And Muscle Morphology Throughout A Block Periodized Training Cycle In Weightlifters, Dylan Guidetti Suarez

Electronic Theses and Dissertations

The purpose of this study was to investigate the kinetic and morphological adaptations that occur during distinct phases of a block periodized training cycle in weightlifters. Monitoring data from nine experienced collegiate weightlifters was examined retrospectively. Isometric mid-thigh pull and ultrasonography results from pre and post three specific training phases within a macrocycle leading up to a competition were compared. Changes in isometric rate of force development and vastus lateralis cross-sectional area reflected the expected adaptations of each training phase.

Systematic Control Of Aged Skeletal Muscle Following High-Intensity Stretch-Shortening Contraction Exercise Training: Epigenomic Regulation And Signaling Factors Underpinning Adaptation, Marshall Alan Naimo Jr.

Graduate Theses, Dissertations, and Problem Reports

Sarcopenia, the age-related decline in skeletal muscle mass, results in a loss of strength and functional capacity, which subsequently increases the risk of disease, disability, frailty, and all-cause mortality. Exercise is known to be an efficacious paradigm for improving health and attenuating or preventing many chronic diseases. For the previous two decades, our laboratory has established an in vivo rodent dynamometer model to explore the effects of various skeletal muscle training paradigms following stretch-shortening contractions (SSCs).The responses tohigh-intensity resistance-type exercise training (RTET) using this physiological model ranges from adaptation, characterized by enhanced skeletal muscle performance along with increased muscle mass, …

Adaptations Made To Evidence-Based Public Health Programs In Low- To Middle- Income Countries: A Concept Mapping Analysis, Elizabeth Holguin

Nursing ETDs

One of the most challenging barriers to implementing successful and sustainable evidence-based programs in public health is the ability to remain faithful to original protocols grounded in scientific evidence while adapting programmatic components to reflect the reality of the communities they are meant to benefit. It is generally accepted that some degree of adaptation should occur in order to achieve positive, sustainable outcomes in public health programs. A concept mapping methodology was used to explore types of adaptation that occur during implementation of evidence-based global health programs in low- to middle-income countries (LMICs). Purposive and snowball sampling produced a sample …

Chronic Migraines And Couples: A Grounded Theory Of Adaptation To Chronic Migraines For Patients And Their Partners, Douglas P. Mcphee

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

This study was completed to better understand and treat couples wherein one partner suffers from chronic migraines. I interviewed eight couples about their experiences in dealing with migraines as a patient, as a partner, and together. The interviews were transcribed and analyzed by a team of seven researchers. We developed a theory that can be used to understand how patients and their partners adapt to chronic migraines. The theory was grounded in the experiences of the patients and partners who were interviewed. We found that patients and partners alike dealt with burdens and costs associated with chronic migraines. Coping, healthcare, …

Articulatory Kinematic Differences During Adaptation To A Bite Block, Madison Ann Mchaley

Theses and Dissertations

The current study examined the effects of bite blocks on articulatory kinematics when producing /r/ within a phrase. Participants consisted of 20 young adults (10 males, 10 females) with no speech, language or hearing disorders. Participants produced the carrier phrase, I say __ with the nonsense words /əri/ (high front vowel), /əræ/ (low front vowel), /əru/ (high back vowel), /ərɑ/ (low back vowel). A Northern Digital Instruments Wave electromagnetic articulograph measured the articulatory movements while the speaker produced the stimuli in two conditions (Pre bite block and post bite block). Bilateral bite blocks were made using Express dental putty, which …

Understanding The Factors Influencing The Perception Of Organizational Sustainability Among Healthcare Professionals (Hcps) Post The Patient Protection And Affordable Care Act, Funso A. Olufade

Seton Hall University Dissertations and Theses (ETDs)

Background and Purpose of the Study: Healthcare costs in the United States has continued to increase annually, and new policy's attempt at protocol changes in healthcare practices does not ensure quality care delivery. An example of these policies include provisions and new guidelines under the 2010 healthcare legislation, - The Patient Protection and Affordable Care Act (ACA). The premise with the Affordable Care Act (ACA) is increased healthcare access for patients. However, not responsibly balancing the increased demand with the escalating cost of care creates an unsustainable system (Department of Health & Human Services, 2015). Healthcare organizations, including hospitals …

Development Of A Journaling Application To Track Progress Of Adaptation To Amplification For Adult Patients: Deardiary, Nicole C. Snider

Dissertations, Theses, and Capstone Projects

The DEar Diary application is an illustration of concept of an Apple iOS (operating system) application designed as a tool for supporting compliance and satisfaction with the use of amplification. The audiologist’s main purpose is to counsel, support and to provide rehabilitative counseling to their patients. Helping a patient succeed while using hearing devices for the first time is a complicated task which can be accomplished with the proper counseling and helpful tools in place.

The use of a journal to write down experiences and providing written support material the patient can refer to once they are out of the …

The Effect Of My Health Companion© On Self-Management And Quality Of Life In Persons With End Stage Renal Disease: A Multiple Case Study Approach, Julie D. Leming

Nursing Theses and Dissertations

End stage renal disease (ESRD) is the fifth and final stage of chronic kidney disease. Persons with ESRD face significant challenges to quality of life when undergoing renal replacement therapy with hemodialysis. Complex medical regimens accompanied by severe physical discomforts related to both ESRD and dialysis can take a serious emotional toll. Two manuscripts presented in this dissertation portfolio explore the issues facing this population. First, a comparative concept analysis explores three potential psychosocial responses for which nurses are uniquely positioned to intervene. A second manuscript details a multiple-case study with embedded units of analysis that aimed to test the …

The Effect Of Ostomate-To-Ostomate Support On Psychosocial Adaptation To Stoma, Marjorie C. Summers

Doctor of Nursing Practice Projects

Approximately one million people in North America are living with an ostomy, and an additional 100,000 will undergo ostomy surgery annually. Persons living with ostomies, often referred to as ostomates, require specialized care and management to sustain physical health and quality of life. Fecal diversion ostomates, when compared to the general population, are more likely to experience psychological disturbance and higher levels of depression. These ostomates have reported increased loneliness, lowered self-esteem, decreased or absent libido, irritability, suicidal ideation, poor self-image, and symptoms of generalized anxiety disorder and social phobia. Being an ostomate has been associated with a reduction in …

Wayne County Board Of Education Adaptation Of Love Notes Curriculum For Adolescent Pregnancy Prevention, Allison Shea Merritt

Theses and Dissertations--Public Health (M.P.H. & Dr.P.H.)

West Virginia has the 8^th highest rate of adolescent pregnancy in the United States and the rate in Wayne County is significantly higher. Adolescent pregnancies cause negative health outcomes for both the baby and the mother. Adolescent mothers are at an increased risk of anemia, preeclampsia, and preterm labor and babies born to adolescent mothers are more likely to have a low birth weight and to have cognitive impairment. To address this burden, the school board has decided to use the ADAPT-ITT framework on the evidence-based Love Notes adolescent pregnancy prevention curriculum to adapt it to be more culturally …

Perceptual Analysis Of Children's Adaptation To An Electropalatography Sensor, Kasey Marie Duffield

Theses and Dissertations

The purpose of this study is to observe childrens adaptation to an electropalatographic (EPG) sensor. Sound recordings of six children between the ages of 7;0 and 9;11 sampled at 30-minute intervals over a two-hour period of wearing an EPG sensor were perceptually evaluated to quantify the children's adaptation over time. Twenty native speakers of American English evaluated the pronunciation of a series of words with embedded stops and fricatives produced with and without an EPG sensor in place. When collapsed over speaker and stimulus type, listener ratings decreased significantly after inserting the EPG sensor. Ratings then increased significantly after the …

Perceptual Analysis Of Children's Adaptation To An Electropalatography Sensor, Kasey Marie Duffield

Theses and Dissertations

The purpose of this study is to observe childrens adaptation to an electropalatographic (EPG) sensor. Sound recordings of six children between the ages of 7;0 and 9;11 sampled at 30-minute intervals over a two-hour period of wearing an EPG sensor were perceptually evaluated to quantify the children's adaptation over time. Twenty native speakers of American English evaluated the pronunciation of a series of words with embedded stops and fricatives produced with and without an EPG sensor in place. When collapsed over speaker and stimulus type, listener ratings decreased significantly after inserting the EPG sensor. Ratings then increased significantly after the …

Neural Processes Underlying Auditory Context Effects, Breanne Yerkes

UNLV Theses, Dissertations, Professional Papers, and Capstones

Auditory information within our natural environments is disorganized and often ambiguous, leaving our auditory systems with a complex task: organizing sound into coherent objects. The auditory system uses both current and prior information to assist in completing this task. The influences of previous context on current perception have been referred to as context effects. A contrastive context effect results in a current perception that is opposite of what is expected based on the physical stimulus properties presented during an immediate context. A facilitative context effect results in a current perception that is the same as the perception during the immediate …

Demographic Factors That Correlate With Adherence To Hemodialysis Treatment Regimen, Brittany Ross

Nursing Theses and Capstone Projects

Background: Research has shown that non-adherence to the recommended treatment regimen in patients with chronic health conditions such as end stage renal disease can have detrimental consequences such as cardiac enlargement, difficulty breathing, cardiac arrest, and death. Several studies have shown a patient’s age, marital status, gender, and family support can affect adherence to treatment regimen in hemodialysis patients. Purpose: The goal of this study was to provide insight into the demographic factors that correlate with adherence to treatment regimen in hemodialysis patients. Method: This research study consisted of a retrospective chart review of 75 charts of chronic outpatient hemodialysis …

The Impact Of Adaptive Leadership Capacity On Complex Organizational Health Systems Outcomes, Laura Lentenbrink

Walden Dissertations and Doctoral Studies

Nonlinear and chaotic environmental changes characterize health services organizations as complex adaptive systems in which leaders must exercise non-traditional leadership practices to succeed. Health services leaders who have learned and implemented traditional linear management approaches are ill prepared to lead in complex environments. This study tested complexity and adaptive leadership theories of agility and resilience in complex health systems. The purpose of this quantitative cross-sectional internet-based survey study was to quantify relationships between independent variables of agility and resilience and secondary dependent variables of financial, patient satisfaction, quality and human capital outcomes. The impact of turbulence was also examined. Included …

Perceptions Of Fidelity And Adaptation In Evidence-Informed Interventions By Women Of Color Sexuality Health Educators, Sara C. Flowers

Dissertations, Theses, and Capstone Projects

Sexuality health educators (SHEs) adapt interventions to the participants’ needs in the dissemination and implementation of comprehensive sexuality education (CSE) programming. However, there is a lack of understanding of how, why and when SHEs make such adaptations. Success or failure of the transfer of prevention technology to practitioners occurs by determining community capacities and preparedness to adopt/adapt high-impact interventions to effectively manage implementation. Experts argue for evidence-informed interventions (EII), as opposed to evidence-based interventions (EBI), as the best way to incorporate research in applied settings. EBIs are solely guided by recommendations from current evidence, whereas EIIs recognize and incorporate the …

A Resiliency Perspective Of The Lived Experience Of Parenting Infants And Young Children With Cystic Fibrosis In The Context Of Early Lung Disease Surveillance, Cindy Branch-Smith

Theses: Doctorates and Masters

Scientific and technological advances over the past few decades have contributed to an exponential increase in life expectancy for infants born with cystic fibrosis (CF), which can cause fatal lung disease. There has been a paradigmatic shift from reactive treatment towards early disease detection and aggressive intervention of paediatric CF. Previous research has investigated parents’ experiences of the diagnosis phase and later life stages such as adolescence and transition to adulthood. Less is understood about the experience of parenting infants and young children with CF, and no research addresses this during early surveillance for CF lung disease. Early surveillance is …

Satellite Cell Behavior In Cyclists Following Intensified Training With And Without Protein Supplementation, Alec I. Mckenzie

Masters Theses, 2010-2019

PURPOSE: The objectives were to determine the satellite cell (SC) response among endurance-trained cyclists (n=8; VO_2max: 63.1 ± 8.4 mL/Kg/min)to a period of intensified training (ICT) (10 days) and 10 days of recovery (RVT), with and without protein supplementation. METHODS: Muscle biopsies were obtained from the vastus lateralis prior to- and immediately following ICT and RVT. Fluorescent microscopy was used to analyze SCs and myosin heavy chain I and IIa (MHC I and IIa). Data were analyzed using magnitude-based inferences. RESULTS: MHC I SCs were exceptionally abundant at baseline (38 ± 20 SCs/100 fibers). MHC I SC count …