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Articles 1 - 3 of 3
Full-Text Articles in Medicine and Health Sciences
Sickle Cell Anemia, Esther Bassaw
Sickle Cell Anemia, Esther Bassaw
Nursing Student Class Projects (Formerly MSN)
Sickle cell anemia (SCA) is an inherited autosomal recessive disorder of red blood cell caused by an abnormality of hemoglobin called sickle hemoglobin (HbS) (Centers for Disease Control and Prevention (CDC), 2017). African countries carry the highest incident of individuals with the SCA(CDC, 2017). In the United State, approximately 1 in 12 African-Americans carry the trait for SCA, and 1 of every 350 African-American infants born have the disorder (CDC, 2017). Individuals with sickle cell disease exhibit significant morbidity and mortality. Clinical manifestations of SCA are chronic hemolysis and acute vaso-occlusive crisis, which causes severe pain, infections, and chronic organ …
A Dedicated Chaperone Mediates The Safe Transfer Of Mitoribosomal Proteins To Their Site Of Assembly, Gabrielle Ashley Hillman
A Dedicated Chaperone Mediates The Safe Transfer Of Mitoribosomal Proteins To Their Site Of Assembly, Gabrielle Ashley Hillman
Graduate School of Biomedical Sciences Theses and Dissertations
Mitochondrial ribosomes are functionally specialized for the synthesis of several essential inner membrane proteins of the respiratory chain. While remarkable progress has recently been made towards understanding the structure of mitoribosomes, the unique pathways and factors that facilitate their biogenesis remain largely unknown. This dissertation defines the physiological role of an evolutionarily conserved yeast protein called Mam33 in mitochondrial ribosome assembly. The biomedical relevance of this finding stems from the fact that mutations or changes in its expression of the human ortholog p32 result in mitochondrial dysfunction. In human patients, bi-allelic mutations cause severe multisystemic defects in mitochondrial energy metabolism, …
Multigenerational Genomic And Epigenetic Effects Of Manufactured Silver Nanomaterials In Caenorhabditis Elegans, Anye Wamucho
Multigenerational Genomic And Epigenetic Effects Of Manufactured Silver Nanomaterials In Caenorhabditis Elegans, Anye Wamucho
Theses and Dissertations--Toxicology and Cancer Biology
There has been an increase in the incorporation of silver nanomaterials into consumer products due to their antimicrobial properties. Therefore there is potential for silver nanoparticles (Ag-NPs) to leach out into the environment during different life-cycle stages of these nanomaterial-containing products. Concern about the toxicity of Ag-NPs has led to investigations into their toxic effects on a variety of organisms mainly using acute and sub-chronic, single-generation exposures. The focus of this project was to understand the effects of long-term continuous multigenerational exposure to AgNO3 and Ag-NPs in both pristine and environmentally transformed forms, on the model organism, Caenorhabditis elegans …