Medicine and Health Sciences Commons^™

The Preferences Of Toileting Habits And Routines In Older Adults, Deanna Orr, Courtney Madary, Bethany Robinson

Older Adult

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A Role Of Vitamin B2 In Reducing Amyloid-Beta Toxicity In A Caenorhabditis Elegans Alzheimer’S Disease Model, Muhammad Tukur Ameen

Electronic Theses and Dissertations

Alzheimer’s disease (AD) is associated with amyloid-beta peptide deposition and loss of mitochondrial function. Using a transgenic C. elegans AD worm model expressing amyloid-beta in body wall muscle, we determined that supplementation with either of the forms of vitamin B₂, flavin mononucleotide (FMN) or flavin adenine dinucleotide (FAD) protected against amyloid-beta mediated paralysis. FMN and FAD were then assayed to determine effects on ATP, oxygen consumption, and reactive oxygen species (ROS) with these compounds not significantly improving any of these mitochondrial bioenergetic functions. Knockdown of the daf-16/FOXO transcriptional regulator or the FAD synthase enzyme completely abrogated the …

Examining The Role Of Ganglioside Homeostasis In Neurodegeneration And Aging Using Maldi Imaging Mass Spectrometry, Sarah Caughlin

Electronic Thesis and Dissertation Repository

Gangliosides are a family of membrane lipids enriched in the central nervous system (CNS) that play an important role in cell signaling processes on the membrane. Alterations in the homeostatic distribution of the a-series family of gangliosides has been observed in both pre-clinical models and human patients with neurodegenerative diseases and injuries, such as Alzheimer’s disease (AD) and strokes. Ganglioside dysregulation has been implicated as an important mechanisms driving pathology in the aging brain, yet there is little information on where and when these lipid changes occur as well as the role of dysregulation during neurodegeneration. Matrix-Assisted Laser Desorption/Ionization (MALDI) …

A Study Of Registered Nursing Students’ Perceptions Of Confidence In Providing Quality Nursing Care To Patients With Alzheimer’S Disease Or Other Dementia, Louanne E. Harto

Doctor of Education (Ed.D)

There are currently millions of persons living with Alzheimer’s disease or other dementia; a number that will rise as the older adult population increases. Patients with Alzheimer’s disease or other dementia who are admitted to the acute care hospital for a physical problem may not receive the same standard of care as those persons without a cognitive impairment. The purpose of this study was to explore the perceptions of students in a prelicensure registered nursing program regarding their confidence to provide patient-centered nursing care to patients with cognitive impairment, specifically Alzheimer’s disease or other dementia. This quantitative study used a …

Is Memantine A Safe And Effective Treatment For Alzheimer’S Disease In Patients Over The Age Of 50?, Stephanie Hoarau

PCOM Physician Assistant Studies Student Scholarship

OBJECTIVE The objective of this selective EBM review is to determine whether or not memantine is a safe and effective treatment for Alzheimer’s disease in patients over the age of 50.

STUDY DESIGN Systematic review of two randomized controlled trials published in 2006 and 2013 and one randomized controlled trial pooled analysis published in 2014.

DATA SOURCES Two randomized controlled trials and one pooled analysis were obtained using PubMed.

OUTCOMES MEASURED Efficacy of memantine as compared to control groups based on cognition, behavior, and adverse events. These were measured using Severe Impairment Battery (SIB), Neuropsychiatric Inventory (NPI), and Behavioral Pathology …

Does Herbal Medicine Have An Effect On The Cognitive Function Of Patients With Mild To Moderate Alzheimer’S Disease Over The Age Of 50?, Melissa Liebman

PCOM Physician Assistant Studies Student Scholarship

OBJECTIVE: The objective of this selective evidence based medicine review is to determine whether or not “herbal medicine has an effect on the cognitive function of patients with mild to moderate Alzheimer’s disease over the age of 50”.

STUDY DESIGN: Review of three double-blind, randomized control trials published between 2003 and 2015. All studies were published in English language in peer reviewed journals.

DATA SOURCES: Three randomized control trials were found via PubMed.

OUTCOMES MEASURED: The outcomes measured include changes in Alzheimer’s symptoms based upon a neurologist, improvement of Alzheimer’s symptoms based on ADAS-cog and CDR-SOB clinical rating scale, and …

Vascular Cognitive Impairment And Dementia: The Importance Of Mixed Pathologies From Mouse Models To Humans, Alex Marian Helman

Theses and Dissertations--Molecular and Cellular Biochemistry

Age-related neurologic disease is a significant and growing burden on our society. Although the largest share of research effort has typically been devoted to the common neurodegenerative illnesses (such as Alzheimer’s disease, or AD), the reality is that nearly all cases of neurodegenerative disease possess elements of mixed pathology. Vascular contributions to cognitive impairment and dementia (VCID) is a complex form of dementia, combining aspects of vascular disease and other forms of dementia, such as Alzheimer’s disease. This pathology is heterogeneous and can include cerebral amyloid angiopathy (CAA), hemorrhages, white matter infarcts, and changes to the neurovascular unit. Given the …

Genetic Determinants Of Rates Of Cognitive Decline In Preclinical Alzheimer’S Disease, Tenielle L. S. Porter

Theses: Doctorates and Masters

In 2015 the number of people worldwide living with Dementia was 46.8 million, with approximately 50-75% of these cases being clinically defined as Alzheimer’s disease (AD). Despite extensive efforts, clinical trials have so far failed to yield a treatment that successfully addresses the underlying cause of AD. This lack of treatment has been suggested, in part, to be a result of late stage of intervention in current clinical trial design. For this reason, greater focus has been placed on preclinical trials and in turn both the identification of individuals at-risk for AD and, amongst these, those that are expected to …