Medicine and Health Sciences Commons^™

The Effects Of Reminder Distinctiveness And Anticipatory Interval On Prospective Memory, Natalee Baldwin

All Theses

Prospective memory failures (or failures to remember a future intention) can result in a wide range of negative consequences. The use of reminders has been shown to improve the rate of PM successes. The aim of the current study was to examine the effectiveness of reminders based on their type (text or picture) and their timing. We hypothesized that successful PM performance would be successfully maintained over longer anticipatory intervals when paired with picture reminders rather than with simple text reminders because of the inherent distinctiveness of pictures. We also expected that performance for younger adults would be better than …

Word Recognition In Noise Among Young And Older Listeners: A Combined Behavioral And Electrophysiological Study, Victoria Ann Williams-Sanchez

USF Tampa Graduate Theses and Dissertations

Word recognition is based on the complex interplay of bottom up processing of acoustic input and corresponding top-down processing based on linguistic redundancies (i.e., contextual cues). Friedrich and Kotz (2007) investigated the timeline of integrating top-down and bottom-up processes among young adults with normal hearing using sentences presented in quiet. As a follow-up study, also with young adults with normal hearing (Experiment 1 of this dissertation), we used sentences embedded in multi-talker background noise and found similar results to Friedrich and Kotz (2007); but, with the use of principal component analysis (PCA) unveiled additional effects of phonological and semantic integration …

Quantifying The Effect Of A Novel Topical Hyaluronic-Acid Phosphatidylethanolamine Cream On The Epidermis, Caitlin J. Symonette

Electronic Thesis and Dissertation Repository

With aging, keratinocytes have diminished proliferative capacity resulting in atrophic skin with reduced barrier function. This investigation evaluates the effect of daily topical applications of a novel high-molecular weight hyaluronan cream (HA-PE) on keratinocyte renewal and epidermal thickness. Unmodified hyaluronan and HA-PE were mixed separately into a vehicle cream. Each topical formulation was applied daily onto the shaved backs of aged female C57BL6 mice. Full-thickness biopsies of treated skin were obtained for analysis of keratinocyte proliferation, keratinocyte differentiation, and local inflammation at days 1, 5, and 10 of cream application. In addition, a cardiac puncture was performed for serum C-reactive …

Role Of Sirt1 In Vascular Complications Of Diabetes, Rokhsana Mortuza

Electronic Thesis and Dissertation Repository

Chronic diabetic complications are significant causes of morbidity. In diabetes, as the cellular changes are similar to aging, we investigated the role of sirtuins (SIRTs) in chronic diabetic complications.

We examined glucose and aging-induced changes in the endothelial cells (ECs), the primary targets of chronic diabetic complications. ECs in high glucose showed evidences of early senescence, being more pronounced in microvascular ECs in association with decreased SIRT1 and FOXO1-dependent reduction in antioxidant gene expressions. A regulatory relationship of deacetylator SIRT1 and histone acetylator p300 was identified. Renal and retinal tissues of diabetic animals showed similar results.

Having established such changes, …

Older Woman Workers: Met And Unmet Needs For Health And Wellbeing In The Workplace, Gillian Gorfine

Electronic Thesis and Dissertation Repository

Older women workers report experiencing occupational injustices however the literature focuses on barriers faced rather than understanding the needs-based strategies empowering women as they age at work. This study engaged women aged 55 and older in a participatory action research project defining and examining strategies for older women workers’ health and wellbeing. In Phase 1, a key informant advisory group (N = 4) defined the problem and guided the design of an open answer survey conducted with 72 older women in work. Three categories emerged informing the fundamental, instrumental, and contextual needs of older women workers. Meeting fundamental needs may …

Specific Cognitive Domains Associated With Gait Performance In Mild Cognitive Impairment, Elyse M. Gordon

Electronic Thesis and Dissertation Repository

The study aim was to identify associations between deficits in specific cognitive domains and gait performance in Mild Cognitive Impairment (MCI). Sixty-eight participants with MCI underwent cognitive function testing in executive function (EF), attention, working memory, episodic memory and language domains. Gait was assessed using an electronic walkway (GaitRite®). The means and co-efficient of variation of five gait parameters were evaluated: velocity, stride time, stride length, step width and double support time during single (SG) and dual-task (DT) test conditions Multivariable linear regression analysis demonstrated deficits in EF, working memory and episodic memory were significantly associated with increased gait variability …

Mechanisms Of Isometric Exercise-Induced Hypoalgesia In Young And Older Adults, Kathy J. Lemley

Dissertations (1934 -)

Pain reduction following exercise (exercise-induced hypoalgesia; EIH) is well-established in young adults. Specific to isometric exercise, the greatest EIH follows low intensity contractions held for long duration. The EIH response of older adults is not known; and the mechanisms for EIH are unclear at any age. This dissertation aimed to address these unknowns through a series of three studies. In study one, repeatability of pressure pain reports (pain threshold and pain ratings) was assessed in healthy older adults, including the impact of psychological factors. Pain reports, measured before and after quiet rest, did not change following quiet rest. Higher state …

Quantifying The Effect Of Age And Contraction Mode On The Force-Velocity-Power Relationship In The Knee Extensors, Justin R. Paturel

Electronic Thesis and Dissertation Repository

PURPOSE: To assess and compare the force-velocity-power relationship (F-V-P) using isotonic and isokinetic knee extensions in 11 younger (19-30y) and 11 older (69-81y) men. METHODS: The construction of the F-V-P curves were attained with each participant performing maximal, explosive knee extensions at 8 different loads (isotonic) and 8 different velocities (isokinetic) on a Cybex HUMAC NORM dynamometer. Maximal voluntary contraction (MVC or P_o), maximal shortening velocity (V_max), maximum power, optimal torque (P_opt) and velocity (V_opt) were assessed and compared. RESULTS: The older men were 43% weaker, 18% slower and ~54% less powerful …

Predictors And Mediators Of Long-Term Functional Limitations In The Older Adult Population, Teresa Maria Bell

Theses and Dissertations (ETD)

With nearly 40 million Americans being treated for nonfatal injuries in emergency departments annually, the burden of nonfatal injury in the United States is extensive. The longterm functional consequences of these injuries can be enduring and far-reaching, especially for older adults. Although studies have reported that persistent functional deficits exist after injury, less information is known about long-term recovery patterns and the factors that influence functional outcomes.

The primary aims of this study are to (1) classify differences in long-term, longitudinal changes in functional limitations within the injured population, (2) identify individual characteristics that predict recovery after injury and (3) …

Acoustic And Respiratory Measures As A Function Of Age In The Male Voice, Mark Selent

ETD Archive

The purpose of this study was to extend understanding of the effects of aging on the male voice by obtaining and analyzing both acoustic and respiratory measures across the aging continuum. Aerodynamic measurements such as vital capacity (VC), maximum phonation time (MPT) and the acoustic measurement Speaking Fundamental Frequency (SFF) are used commonly in Speech-language Pathology to aid in the assessment and treatment outcomes of vocal dysfunction. However, current research lacks analysis of the interaction across these parameters within males and younger ages. This information may be important in understanding the normal changes in the speech mechanism with age and …

Cardiovascular Aging In The Female F344xbn Rat Model, Jacqueline C. Fannin

Theses, Dissertations and Capstones

Despite continued advances in medical care, cardiovascular disease (CVD) remains the leading cause of death for American women [1]. Although humans and non-human primates are the only mammals to experience menses, rodent models are commonly used to study age-associated cardiovascular alterations due to similar ovarian aging, low expense, and short lifetime to investigate cardiovascular aging. Previous studies have found that aging in the female rodent is characterized by increased ventricular apoptosis, elevations in oxidative-nitrosative stress, ventricular remodeling, increased collagen content, mild systolic and diastolic dysfunction, and reduced occurrence of arrhythmias compared to males [2-7]. Similarly, age-associated alterations in the female …

An Analysis Of The Effect Of Ss-Hydroxy-Ss-Methylbutyrate On The Flight Ability And Lifespan Of Drosophila Melanogaster, Alexandra Elizabeth Beattie

Graduate College Dissertations and Theses

As muscle function deteriorates with age, the discovery of new ways to enhance the quality of human life by stunting inevitable aging processes, such as sarcopenia, is a subject of great interest to aging populations, to health care professionals and to nutritional companies. β-hydroxy-β-methylbutyrate (HMB) enhances muscle strength in humans and attenuates disease-induced and disuse-dependent atrophy in rodents. We investigated the feasibility of utilizing Drosophila as a model organism to study the biological effects of HMB in aging muscle. Using flight ability as an index of muscle function and monitoring the lifespan of flies, we found that normal food supplemented …

Do Stimulant-Type Drugs Help Improve Cognitive Function And Apathy In Geriatric Patients?, Jacquelyn Menarde

PCOM Physician Assistant Studies Student Scholarship

OBJECTIVE: The objective of this systematic review is to determine whether or not stimulant type medications help to improve cognitive function and apathy in geriatric patients.

STUDY DESIGN: Systematic review of three English language primary studies published in 2001 and 2008.

DATA SOURCES: Two randomized control trials and one individual randomized control trial comparing methylphenidate administration to placebo for improvement in cognitive function and apathetic mood in elderly patients were obtained using PubMed.

OUTCOMES MEASURED: Clinical outcomes of apathy were measured according to the Apathy Evaluation Scale (AES), Neuropsychiatric Inventory (NPI), the Montgomery Asberg Depression Rating …

Accumulation Of Subcortical Iron As A Modifier Of Volumetric And Cognitive Decline In Healthy Aging: Two Longitudinal Studies, Ana Marie Daugherty

Wayne State University Dissertations

Accumulation of non-heme iron in the brain has been theorized as a cellular mechanism underlying global neural and cognitive decline in normal aging and neurodegenerative disease. Relatively few studies of brain iron in normal aging exist and extant studies are almost exclusively cross-sectional. Here, I estimated iron content via T2* and measured volumes in several brain regions in two independent samples of healthy adults. The first sample (N = 89) was measured twice with a two-year delay; and the second sample (N = 32) was assessed four times over a span of 7 years. Latent models estimated change in iron …

Gut Microbiome And Its Role In Obesity And Aging In C57bl/6j Mice, Yongbin Yang

All ETDs from UAB

The gut microbiome has been found to be associated with obesity, type 2 diabetes and many other diseases. Many studies have shown microbial composition changes with obese status or switching of diets. However, few of them have investigated the long-term microbial changes in subjects under the same environmental factors. This study examined gut microbiome changes in multiple aspects with well-controlled diet-induced obese mice models and demonstrated the following: there were great variations in gut microbiome composition and diversity in the same strain of inbred mice under the same environment and diet; certain lineages of bacteria were associated with digestive efficiency; …