Medicine and Health Sciences Commons^™

Functional 3-D Cellulose & Nitrocellulose Paper-Based, Multiplex Diagnostic Platforms Without Coupling Agents, Mackenzie Elizabeth Tageson

Master's Theses

The purpose of this thesis was to demonstrate device functionality of 3-D paper-based, multiplex platforms, µPADs, without the use of coupling agents between layers. Previously, these platforms were fabricated with double-sided tape and cellulose powder to try to augment proper fluid routing, but difficulties with this method occurred. An acrylic housing unit with strategically placed pressure tabs was designed to aid horizontal and vertical fluid routing through the platform, thus eliminating the inconsistencies associated with coupling agents. Channel characterization studies, a COMSOL^TM simulation, and development time studies were performed to aid device design and demonstrate device functionality.

The implementation …

Formulation Development Of A Polymer-Drug Matrix With A Controlled Release Profile For The Treatment Of Glaucoma, Eric W. Tsoi

Master's Theses

Glaucoma is the leading cause of blindness in the United States accounting for 9-12% of all cases of blindness. Currently, the front line treatment for glaucoma are prostaglandins that may have to be taken up to several times a day. Even with proper treatment, roughly 11% of the patients using the treatment are non-compliant and lose their vision. In this project, ForSight Laboratories has developed a pharmaceutical drug delivering implant with the capability of sustaining long-term release of a prostaglandin as a new way to treat the condition. This project reports the product development of a polymer drug matrix with …

The Effects Of 8 Weeks Of Low Dose Supplementation Of Creatine And Sodium Bicarbonate On Exercise Performance, Amanda Jessica Morris

Master's Theses

Short-term (3-7 days), high doses of creatine (20g/d) and/or sodium bicarbonate (0.5g/kg body weight) supplementation increase exercise performance during short term high intensity activities; however, it remains unclear whether long-term, low doses of these supplements have a positive impact on exercise performance. The purpose of this study was to determine the effects of long-term (8 weeks), low dose creatine supplementation on exercise performance, and whether combining creatine and sodium bicarbonate supplementation has an additive effect. Sixty-three healthy, habitually active, adults (28 M, 35 W; 22+2 years; 23+ 3 BMI) were randomly assigned by sex to one of three supplement groups: …

The Stress Revolution: An Examination Of Acculturative Stress And An Emerging Modern Human Stress Response, Jeffrey Nicklas

Social Sciences

In a world that is so fast pace and always changing, the human biological systems have need to adapt just as swiftly. WIth the dependence on culture that humans all share has led to the building of societies with complex rules, ideals, and accepted roles and ways of life. In these complex societies, great cities and governments have arisen but so too have unnoticed changes to human biology. One of these changes is with environmental stressors and the effects it has on the nervous system. The human body, in these modern times, still responds to perceived stressors with the release …

Beach Wheelchair Project, Rory Aronson, Joshua Marcum, Samuel Coyne, Alex Hayes, Alexa Colburn, Max Hessel, Benedikt Strauss, Marvin Rimmele, Marco Pietsch

Mechanical Engineering

The Beach Wheelchair, Sandcrawler, is a machine intended to help give people with disabilities the full beach experience. The non-profit organization Bridge II Sports sponsored this project, and tasked us with developing the design and fabricating a prototype. This chair has several features including a linkage mechanism that raises and lowers a chair relative to an external frame, hand crank drive with Gates Carbondrive belt and sprockets, buoyant Wheeleez balloon tires, and much more.

Hoist To Transfer Athletes From Wheelchair Into A Kayak, Jennifer Batryn, Javier Mendez, Kyle Mooney

Mechanical Engineering

No abstract provided.

Fluorescence Characterization Of Quantum Dots For Use As Biomarkers, Logan M. Grimes

Materials Engineering

Fluorescence profiles of quantum dots (QDs) were characterized to select the ideal QDs for encapsulation in phospholipids for use as biomarkers to selectively adhere to cancer cells. QDs were synthesized and extracted 0, 30, 60, and 90 seconds after precursor compounds were mixed. These extractions were isolated by extraction time. Portions from each vial were coated in a zinc sulfide shelling procedure, leaving at least half of the QD solution unshelled. These samples were characterized over four days to monitor fluctuations in fluorescence. This was done utilizing an Ocean Optics spectrometer in conjunction with Spectra Suite software. The central wavelength, …

Evaluation Of Degradation Of The Chicken Egg Over Time By Method Of Haugh Unit Score, Serena Gurley

Animal Science

The purpose of this senior project was to measure the degradation of the chicken egg over time under different treatments. 864 eggs were collected and divided into six treatment groups. The six groups of study were refrigerated: unwashed, washed, washed and oiled as well as room temperature: unwashed, washed, washed and oiled. The Haugh unit score was measured individually for one dozen eggs taken randomly from each of the six groups once a week for twelve weeks. The Haugh unit score statistical assessment of the eggs found washed and oiled eggs held in refrigeration maintain freshness longer than the other …

Childhood Obesity And Overweight: Causes And Implications In Preschool Children, Melissa L. Sittner

Kinesiology and Public Health

The root causes of childhood obesity and overweight are currently hot topics of research. While many causes have been discovered, researchers are still weighing them against one another while taking the lifestyles of at-risk populations into account. Some of these causes include lack of physical activity, increase in screen time, and the implications of health disparities borne of a child’s socioeconomic status. These causes and more are reviewed further and applied to the population of interest: preschool aged children in the United States, and more specifically preschool aged children of San Luis Obispo County in California. The need for multi-level …

Urban Agriculture Stormwater Management In California Cities, Rachel L. Cohen

Master's Theses

Cities within California are beginning to incorporate urban agriculture into their land use designations. Prompted by residents and local organizations, cities are hoping to capture the benefits that urban agriculture provides. Research has shown that urban agriculture renews and beautifies neighborhoods, provides healthy food choices, increases public health, has the potential to help with stormwater runoff, creates jobs, and fosters community. In the last few years, several California cities have made headlines as they have adopted new zoning codes that include urban agriculture.

In reviewing these new zoning codes and exploring the topic of urban agriculture, it became evident that …

Evaluation Of The Anterior Talofibular And Calcaneofibular Ligament In Relation To Supination Ankle Sprains, Peter Tran

Biomedical Engineering

Ankle injuries have always posed an issue to a number of athletes. Sports that involve running and jumping accumulate about 25% of injuries correlating to ankle sprains. In most ankle sprains the inversion (supination) of the ankle cause damage to lateral ligaments. The two most common lateral ligaments to experience damage are the anterior talofibular (ATFL) and calcaneofibular (CFL) ligaments. The methods of taping and ankle braces have allowed athletes to prevent recurring sprains from occurring. However, sprains can still occur even when one or both methods are applied. The purpose of each method is to restrict the range of …

Navy Seal Prosthetic Hand, Devon Patrick Augustus

Master's Theses

Prosthetic development recently has focused mainly on myoelectrically controlled electric hands despite a majority of upper extremity amputees actively choosing body powered devices. Myoelectric hands utilize a small electric pulse generated in muscles when flexing as a signal to the hand to close. Finger flexion in these devices is controlled by electromechanical servos, requiring no strength input from the user. Body powered devices use a cable attached to a shoulder harness which causes mechanical closure of the device via tension placed on a control cable by a shoulder shrug motion or arm extension. Outfitting of active duty service personnel has …

High School Athletic Directors Perceptions Of Athletic Trainer's Professional Knowledge And Competence Based On Attire, Raechel N. Cunningham

Master's Theses

Very little research is available to identify how attire in the athletic training field impacts perceptions of professional knowledge and competence. The purpose of this study was to identify the effect of attire on high school athletic directors’ perceptions of an athletic trainer’s professional knowledge and competence. The researcher emailed a questionnaire to ninety-four high school athletic directors from the state of California. The questionnaire measured the effect of attire on the perceptions of skills, knowledge, approachability, experience, education level, overall competence, and representation of an athletic trainer and focused on the difference between khaki attire, professional attire, and workout …

Speed And Agility Training The Mustang Way: The Development Of An Instructional Dvd For Cal Poly Athletes' Summer Training, Gary D. Heron

Master's Theses

SPEED AND AGILITY TRAINING THE MUSTANG WAY:

THE DEVELOPMENT OF AN INSTRUCTIONAL DVD FOR CAL POLY ATHLETES’ SUMMER TRAINING

Gary Douglas Heron

The purpose of this project was to create an instructional DVD of speed and agility training for Cal Poly student-athletes. The DVD is for athletes’ use when they are away from campus during summer break and contains information about the same drills and information the strength and conditioning coaches provided while athletes were on campus. The project was filmed and edited by the graduate assistant strength and conditioning coach for Cal Poly intercollegiate athletics. The DVD contains 74 …

Establishment And Validation Of A Novel Fucci (Fluorescent Ubiquitination-Based Cell Cycle Indicator) In An In Vitro Chronic Myeloid Leukemia Model, Jane Marie Isquith

Master's Theses

The deregulation of the cell cycle is important in the leukemic transformation and in the continued discovery of more efficient targeted therapies. After elucidation of the role of the RNA editor ADAR1 in the malignant reprogramming of Chronic Myeloid Leukemia (CML) progenitors to leukemia stem cells (LSCs) during the chronic phase to blast crisis stages of the disease, current research seeks to uncover the mechanism of action of ADAR1 in this process. To study the potential role ADAR1 plays in the changes to cell cycle during this disease progression, a novel Fucci (fluorescent ubiquitination-based cell cycle indicator) system was introduced …

Associations Between Alcohol Consumption And Fasting Blood Glucose In Young Adults, Julie Ann Lucca

Master's Theses

Current research shows moderate alcohol consumption is associated with decreased risk of diabetes and excessive consumption or binge drinking can cause insulin resistance and diabetes. In 2010, diabetes was the seventh leading cause of death in the United Statesand was responsible for significant health complications: blindness, kidney failure, and limb amputations, and is a large national economic burden. Fasting blood glucose (FBG) is a tool used to help diagnose diabetes. Abnormally high FBG, ≥100 mg/dl, is indicative of diabetes and pre-diabetes. Few studies have observed diabetic prevalence among young adults or college students. Studying young adults can help provide added …

Estimating The Impact Of Lost To Follow-Up On Breast Cancer Patients' Disease-Free Survival, Debbie Yan Qun Huang

Statistics

Background The 5-year survival rate for patients with breast cancer is much higher than patients with other types of cancer. Due to this longer survival period, breast cancer patients also tend to have increased rates of lost to follow-up, when compared to other cancers. When a patient becomes lost, the occurrence of distant metastasis cannot be reliably ascertained, unless the patient had a breast cancer-specific (BC) death. The impact of lost patients on recurrence rates and disease-free survival (DFS) was explored in breast cancer patients seen at the City of Hope from 1997 to 2012.

Methods Female breast cancer patients …

Determinants Of Food Insecurity Among Vulnerable White And Latino Households: Contextualizing The Impact Of Sociodemographic And Household-Level Factors, Alexandra Lund

Master's Theses

Household-level characteristics have been shown to be associated with food insecurity but studies among vulnerable populations are sparse. A food security assessment was developed to determine food security and collect sociodemographic and household level data across San Luis Obispo County. The assessments were administered to vulnerable groups through interviews at multiple sites across the County. Three household characteristics (marital status, number of children in the household and number of workers in the household) were examined in this analysis. A total of 808 surveys were collected, 69% in English and 31% in Spanish. Through ethnicity-stratified sequentially adjusted logistic regression models, the …

Parenting Nutrition Skills Workshop: An Evaluation Of Facilitated Group Discussions To Enhance Parenting Nutrition Self Efficacy, Lisa A. Dawes

Master's Theses

Abstract

Parenting Nutrition Skills Workshops: An Evaluation of Facilitated Group Discussions to Enhance Parenting Nutrition Self-Efficacy

By: Lisa Dawes, RD, CDE

This research study was conducted to determine the effectiveness of using facilitated group discussion (FGD), a less traditional method of nutrition education, for increasing parents’ feelings of self-efficacy in their ability to make nutrition-related decisions, and to set and enforce nutrition-related boundaries with their children.

Childhood obesity is on the rise; poor food choices, portion control, and inactivity are identified as contributing causes. Parents play a major role in creating healthy habits and providing a well-balanced diet for their …

The Relationship Between Vitamin D Status Of Adult Women And Diet, Sun Exposure, Skin Reflectance, Body Composition, And Insulin Sensitivity, Marisa M. Mcadler

Master's Theses

As the prevalence of vitamin D deficiency continues to grow, mounting evidence supporting its link with chronic disease strengthens suggesting vitamin D’s candidacy in the prevention and treatment of multiple disease states and their complications. Dietary guidelines, however, do not take sun exposure into account. The present study sought to explore the impact of sun exposure on vitamin D status (serum 25(OH)D), and identify other significant determinants of serum levels which may have the greatest effects on overall health. Participants (n = 34) were pre-menopausal women aged 18 to 50 years (mean age 39 ± 6 years), who had their …

Is Obesity Socially Contagious?, Ciani Jean Sparks

Statistics

The main objective of this paper is to analyze three different articles that discuss whether obesity could be socially contagious. According to the World Health Organization in 2013, obesity is the fifth leading risk for deaths around the world. This disease has dramatically increased in the last decade, which has led scientists to believe there are other factors contributing to the epidemic besides genetics. The first article I analyzed, written by Nicholas Christakis and James Fowler, provided a logistic regression model to estimate the odds of a person becoming obese. The model included the explanatory variables: age, sex, education, smoking …

Perceptions Of Herbal Remedies Among California Polytechnic University, San Luis Obispo Students, Maria Cacciatore, Kimmie Layland, Nicole Morrisey

Social Sciences

Many practitioners now recognize that herbal remedies can be an effective and natural alternative to the standard American, western biomedicine. The objective of our research project is to discover the perceptions about herbal remedies as alternative medicine among Cal Poly students. Specifically we ask, why are they chosen and how students gauge their effectiveness. We seek to see if students have experimented with these herbal remedies, why they chose this route for wellness, and how they value the use of herbal alternative. If we are successful in this project, we will have a greater understanding of how young educated adults …

Rfid Technology Selection And Economic Justification For Healthcare Asset Tracking, Tyler Robert Peabody, Tali Freed

Master's Theses

Although Radio Frequency Identification (RFID) and Real-Time Location System (RTLS) technologies for inventory tracking have been growing in popularity, the healthcare industry has been reluctant to adopt these technologies. One of the primary reasons for this lack of enthusiasm has been the risk associated with electromagnetic interference between RFID/RTLS systems and medical equipment functionality. The other reason has been the substantial cost and complexity of implementing RFID/RTLS in healthcare organizations. In this study, we show that there are several ways to safely install RFID/RTLS systems to improve the inventory management processes of hospitals and clinics. We then analyze the inventory …

Exploring The Efficacy Of The Community Organization Health Model As A Tool For Evaluating Sport-For-Development Programs: A Qualitative Content Analysis Of Three Model Programs, Lauren Faye Denman

Master's Theses

The HIV/AIDS pandemic is currently one of the most pressing world-wide concerns regarding the health and well-being of our global population. Due to the lack of a cure, recent efforts have focused on prevention measures for the disease. HIV prevention, particularly with the youth population, has spawned creative programs, such as the use of sport as an educational tool to equip youth with the skills to avoid contracting HIV. Due to the potent effect sport-for-development efforts exhibit on both individual and cultural level change, it can be assumed that HIV prevention sport-for-development programs are worth maintaining. Within the use of …