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- Behavioral Ecology; Toxic Biological Secretions; Threat Assessment; Venom Expenditure; Defensive Behaviors (1)
- Breast Feeding -- physiology (1)
- Cerebral Brain Flow; Juvenile Brains; Brain Endothelial Permeability; Traumatic Brain Injury; TBI; BBB; (1)
- Cross-Cultural Studies. (1)
- Fetal Development (1)
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- Fetal Intrauterine Growth Restriction; Uterine Vascular Adaptation; Basal Uterine Vascular Tone; (1)
- Health Behavior (1)
- Hispanic Americans (1)
- Maternal-Fetal Exchange -- physiology (1)
- Nutrition Processes (1)
- Obesity -- etiology (1)
- Pregnancy (1)
- Prenatal Exposure Delayed Effects (1)
- Socioeconomic Factors (1)
Articles 1 - 5 of 5
Full-Text Articles in Medicine and Health Sciences
Expression And Function Of Ca2+-Activated K+ Channels In Uterine Arteries, Ronghui Zhu
Expression And Function Of Ca2+-Activated K+ Channels In Uterine Arteries, Ronghui Zhu
Loma Linda University Electronic Theses, Dissertations & Projects
Chronic hypoxia during pregnancy is one of the most common insults to the maternal cardiovascular system and fetal development, and is associated with increased uterine vascular tone and heightened risk of preeclampsia and fetal intrauterine growth restriction (IUGR). The present study tested the hypothesis that calcium-activated potassium (KCa) channels play an essential role in uterine vascular adaptation to pregnancy, which is inhibited by chronic hypoxia during gestation. Uterine arteries (UAs) were isolated from nonpregnant ewes (NPUAs) and near-term pregnant ewes (PUAs) that had been maintained at sea level (~300 m) or exposed to high altitude (3,801 m) for 110 days. …
Caveolins And Njks Influence Brain Endothelial Permeability After Juvenile Tbi, David Olufemi Ajao
Caveolins And Njks Influence Brain Endothelial Permeability After Juvenile Tbi, David Olufemi Ajao
Loma Linda University Electronic Theses, Dissertations & Projects
Disruption of blood-brain barrier (BBB) is a key secondary event that exacerbates brain damage following traumatic brain injury (TBI). BBB disruption is particularly damaging to the developing brain – which is highly vulnerable to various stress stimuli, resulting in increased brain swelling, disrupted cerebral blood flow (CBF) autoregulation, long-term disabilities and death following TBI in young demographic. Unsurprisingly, BBB disruption and the resultant cerebral edema have emerged as therapeutic targets in juvenile TBI. It is therefore important to understand the molecular players and mechanisms involved in TBI-induced BBB disruption in the juvenile brain. To this end, the endothelial caveolins and …
Fetal Programming And Later Obesity In A Predominantly Latino Wic Population, Eric George Walsh
Fetal Programming And Later Obesity In A Predominantly Latino Wic Population, Eric George Walsh
Loma Linda University Electronic Theses, Dissertations & Projects
Background: In utero stressors may work to program the metabolism of the developing fetus in such a way that predisposes him/her to obesity later on. Studies have shown that breastfeeding is protective against childhood obesity and suggest that after six months the weight gain in breastfed babies slows opposed to formula fed babies who continue with rapid weight gain. This slowing of weight gain has been shown to be protective against adiposity and later life weight gain.
Purpose: This study looks to further explore these findings in a low income Latino population adding mother’s feelings about the pregnancy and the …
Ontogeny Of Venom Use And Venom Composition In The Western Widow Spider Latrodectus Hesperus, David Roger Nelsen
Ontogeny Of Venom Use And Venom Composition In The Western Widow Spider Latrodectus Hesperus, David Roger Nelsen
Loma Linda University Electronic Theses, Dissertations & Projects
I investigated the behavioral ecology of venom and venom use by the western widow spider (Latrodectus hesperus), emphasizing the role of ontogeny. In an introductory paper, I reviewed existing definitions of venom and poison, and refined these by adding a third category of toxic biological secretions: toxungen. These three can be distinguished by mode of toxin delivery and presence of a wound. In the first of four empirical studies, I investigated venom use by adult females in the context of threat assessment. A single brief poke at the lowest threat level elicited primarily avoidance responses ("move" and "retract"), repeated prodding …
Small Molecule Inhibitors Of Hpv16 E6, Chung-Hsiang Yuan
Small Molecule Inhibitors Of Hpv16 E6, Chung-Hsiang Yuan
Loma Linda University Electronic Theses, Dissertations & Projects
High-risk human papillomaviruses (HR-HPVs) cause nearly all cases of cervical cancer. HPV 16 E6, one of two viral oncogenes, protects cells from apoptosis by binding to and accelerating the degradation of several apoptotic proteins, including caspase 8 and p53. We proposed that blocking the interactions between HPV E6 and its partners using small molecules had the potential to re-sensitize HPV+ cells to apoptosis. To test this prediction, we screened libraries of small molecules for candidates that could block E6/caspase 8 binding, and identified several candidates from different chemical classes. Testing hits for dose-dependency and specificity in vitro and for toxicity …