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Full-Text Articles in Medicine and Health Sciences
The Effects Of A Moisture-Wicking Fabric Shirt On The Physiological Responses During Acute Exercise In The Heat, Kimberly Wigboldy
The Effects Of A Moisture-Wicking Fabric Shirt On The Physiological Responses During Acute Exercise In The Heat, Kimberly Wigboldy
Masters Theses
The purpose of this study is to investigate the effects that a form fitted, moisture-wicking fabric shirt, promoted to have improved evaporative and ventilation properties, has on the thermoregulatory, physiological and perceptual response during moderate intensity exercise in the heat for an extended duration of exercise of 90 minutes. Ten healthy subjects (7 males, 3 females), completed two heat stress tests consisting of 20 minute seated rest in a neutral environment (24°C, 60% RH), 30 minute seated rest in a hot environment (33°C, 60% RH), and 90 minutes of exercise(50% V02 peak) on a magnetically-braked cycle ergometerin a …
Use Of A Specific Alpha7 Nicotinic Acetylcholine Receptor Agonist Can Prevent Loss Of Retinal Ganglion Cells In An In Vivo Rat Glaucoma Model, David Mata
Masters Theses
Acetylcholine (ACh) has been shown to have a neuroprotective effect against glutamate-induced excitotoxicity in cultured retinal ganglion cells (RGCs) through activation of α7 nicotinic ACh receptors (nAChRs). In this study, the neuroprotective effects of the α7 nAChR agonist, PNU-282987, were investigated using an in vivo model of glaucoma in adult Long Evans rats. Hypertonic saline injections were used to induce a glaucoma model. After one month, retinas were removed, flat mounted, fixed and labeled with an antibody against Thy 1.1 to label RGCs and fluorescently tagged for visualization. Eye drop application of PNU-282987 resulted in neuroprotection against RGC loss in …
Expression Of The Chemokine Receptor, Cxcr4, And Its Ligand, Sdf-1, Are Increased In Purkinje Cells Of The Multiple System Atrophy Cerebellum, Megan Welter
Masters Theses
Multiple System Atrophy (MSA) is a sporadic, neurodegenerative disease that consists of three conditions: autonomic dysfunction, Parkinsonism and cerebellar ataxia. Our lab conducted an Affymetrix global gene expression analysis using pons tissue of MSA patients to determine genes that are differentially expressed when compared to non- MSA controls. This study identified upregulated genes, including the C-X-C chemokine receptor type 4, CXCR4, to which stromal cell-derived factor-I (SDF-1) is the natural ligand. The CXCR4/SDF-1 signaling pair has been sho.wn to play multiple roles in the brain, such as inducing neuronal apoptosis and promoting leukocyte recruitment during inflammation. The MSA cerebellum presents …
Discovery And Characterization Of A Tanapoxvirus Encoded Human Neuregulin Mimetic, David Jeng
Discovery And Characterization Of A Tanapoxvirus Encoded Human Neuregulin Mimetic, David Jeng
Dissertations
Studies on large dsDNA viruses such as poxviruses have been helpful in identifying a number of viral and cellular growth factors that contribute to our broad understanding of virus-host interaction. Orthopoxviruses and leporipoxviruses are among the most studied viruses in this aspect. However, tanapoxvirus (TPV) a member of the genus Yatapoxvirus, still remains largely unexplored, as the only known hosts for this virus are humans and monkeys. Here, we describe the initial characterization of an EGF-like growth factor mimicking human neuregulin from TPV, expressed by the TPV-15L gene. Assays using a baculovirus expressed and tagged TPV-15L protein demonstrated the ability …