Medicine and Health Sciences Commons^™

Beta-Adrenergic, Arachidonic Acid And Potassium Channel Associated-Regulation Of Human Breast Cancer Cell Lines, Yavuz Cakir

Doctoral Dissertations

During the late stages of breast cancer progression, breast cancer cell growth switches from steroid hormone to growth factor dependence, and it is assumed that invasive breast cancers are growth factor receptor positive and estrogen hormone resistant. The cellular arachidonic acid (AA) pathway is upregulated in a variety of cancer types, and it may play an important role in the growth regulation of breast cancer cells.

Recent evidence suggests that beta-adrenergic receptors (β-ARs) are expressed in some estrogen receptor (ER) negative breast cancers and that beta agonists not only can trigger AA release via the activation of cytosolic PLA2 or …

Expression And Characterization Of The Mhc Class Ii Transactivator In K-562 Cells, Noel Elyssa Day

Doctoral Dissertations

The K-562 cell line was developed from the pleural effusion of a patient with chronic myelogenous leukemia (CML) in blast crisis and has served as an excellent model to study the properties of CML cells. The highly undifferentiated cells can be induced by a variety of chemicals to follow multiple pathways of differentiation. When K-562 cells were treated with phorbol myristate acetate (PMA), they exhibited accessory cell functions by replacing monocytes in the activation of resting Th2 lymphocytes. However, K-562 cells are negative for the expression of class II major histocompatibility complex (MHC) antigens HLA-DR, -DP, and -DQ. The focus …

An Examination Of Selected Vowel Structures Of Three Generations Of Native Appalachian English Speakers, Melinda L. Richards

Doctoral Dissertations

Appalachian English (AppE) is a relic dialect, until recently considered to be resistant to change due to the relative isolation of its speakers. AppE may have become an “endangered dialect,” much in the same manner as other insular dialects such as those spoken on Ocracoke Island, Smith Island, and the Sea Islands (Wolfram & Schilling-Estes, 1995; Wolfram & Schilling-Estes, 1998). The purpose of this investigation was to answer two research questions: (1) Are there significant cross-generational differences in the production of eight selected vowels during conversational speech, and (2) Are there significant cross-generational differences in the degree to which speakers …

Agouti Mice Models To Study The Diabetogenicity Of Fk506 (Tacrolimus), Rashika Joshi

Masters Theses

Dominant mutations in the promoter region of the mouse agouti gene lead to a syndrome characterized by agouti yellow coat color, obesity, hyperinsulinemia, hyperglycemia, type II diabetes and increased linear growth. The mechanism of agouti modulation of the coat color development as well as obesity involves competitive antagonism of the ? -melanocortin stimulating hormone at its receptor.

Hyperplasia of the pancreatic ? cells in agouti mice precedes the development of obesity. Enhanced insulin secretion is induced in vitro by agouti effects on calcium influx into islet cells. Preliminary testing of insulin producing pancreatic cells has shown that exposure to high …

The Meaning Of High-Quality Nursing Care As Derived From King's Interacting Systems, Mary Ellen Gunther

Doctoral Dissertations

The purpose of this study is to conceptualize quality with in a framework unique to nursing, King's Interacting Systems. Clarification of the concept with in the metaparadigm and a nursing conceptual framework provides the understanding of the domain and scope of nursing necessary for professional autonomy. This differentiation fosters the continued development of the discipline as well as facilitating collaboration with medicine and other health care disciplines for the ultimate benefit of the patient.

Gadamer's philosophical hermeneutics involves a dialogical interaction between the whole and parts of the text and between the horizons of the text and the interpreter. In …