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Articles 1 - 7 of 7
Full-Text Articles in Medicine and Health Sciences
Fungi-Derived Natural Products With Binding Affinities For Human Opioid Or Cannabinoid Receptors, Jiangtao Gao
Fungi-Derived Natural Products With Binding Affinities For Human Opioid Or Cannabinoid Receptors, Jiangtao Gao
Electronic Theses and Dissertations
Both opioid and cannabinoid receptors belong to the large superfamily of GPCRs and play an important role in a variety of processes including pain, craving, neurodegeneration, metabolic regulation, anxiety and immune function. Therefore, recent advances and discoveries in opioid and cannabinoid receptors have paved the way for a very exciting future for opioid and cannabinoid receptors-based therapies to potentially treat a variety of conditions. However, the growing realizations of the complexity of these two receptors regulation in physiological and pathological conditions have discouraged the development of new therapeutics. So, it is important for us to identify new chemical scaffolds which …
Preparation And Characterization Of Lyophilized Cyclodextrin Complexes Of A Hemisuccinate Ester Of Delta-9-Tetrahydrocannabinol For Transmucosal Delivery, Sampada Bhaskar Upadhye
Preparation And Characterization Of Lyophilized Cyclodextrin Complexes Of A Hemisuccinate Ester Of Delta-9-Tetrahydrocannabinol For Transmucosal Delivery, Sampada Bhaskar Upadhye
Electronic Theses and Dissertations
Delta-9- Tetrahydrocannabinol (THC) is the primary active ingredient of the plant Cannabis sativa (marijuana), responsible for the majority of the pharmacological effects. The most promising clinical applications of THC approved by the Food and Drug Administration (FDA) are for the control of nausea and vomiting associated with chemotherapy and for appetite stimulation of AIDS patients suffering from anorexia and wasting syndrome. The only dosage form currently approved by FDA is an oral, soft gelatin capsule (e.g. Marinol®). In addition, orally administered THC from Marinol® has shown slow and variable absorption due to low oral solubility and first pass metabolism. Our …
Pharmacists' Rating Of Relevance Of Available Information In Deciding The Validity Of Opioid Medication Prescriptions, Leonardo Roberto Torres
Pharmacists' Rating Of Relevance Of Available Information In Deciding The Validity Of Opioid Medication Prescriptions, Leonardo Roberto Torres
Electronic Theses and Dissertations
Pharmacists are tasked with making decisions regarding the validity of prescriptions. Some have proposed factors that should be considered when evaluating a prescription's validity. Yet, there is little known about the decision process that pharmacists employ at the time of dispensing and what information pharmacists deem relevant in that decision-making process. Using an online survey instrument, a sample of community pharmacists were divided into three groups and presented with a prescription scenario. They were asked to rate the relevance of information, which is proposed to be appropriate and inappropriate, available at the time of dispensing. They were asked to consider …
Willingness To Influence Indication-Based Off-Label Prescribing: An Investigation Of Hospital Pharmacists, Ram Sankar Basak
Willingness To Influence Indication-Based Off-Label Prescribing: An Investigation Of Hospital Pharmacists, Ram Sankar Basak
Electronic Theses and Dissertations
Off-label prescribing is a comand legal practice in the United States. However, off-label prescribing occurs oftentimes with inadequate evidence of effectiveness. Such practice, especially when prescribing for disease conditions different from approved clinical indications (indication-based off-label prescribing), brings about controversy and raises different issues with various stakeholders. Although indication-based off-label prescribing offers advantages in terms of providing innovative therapy, it raises concerns because the safety and efficacy of such use may not be evaluated adequately. Thus, the objective of the study was to examine whether pharmacists are willing to influence physicians while evaluating an indication-based off-label medication order. Based on …
Determinants Of Bone Mineral Density In African-American And Caucasian College-Aged Women, Andrea K. Johnson
Determinants Of Bone Mineral Density In African-American And Caucasian College-Aged Women, Andrea K. Johnson
Electronic Theses and Dissertations
Osteoporosis is a serious health issue affecting 10 million Americans, with an additional 44 million being at risk. Due to the morbidity and mortality associated with fractures caused by osteoporosis, it is an important public health concern. Some researchers suggest that African-American women fracture at a lower rate when compared to Caucasians with the same bone mineral density (BMD). However, when African-American women do fracture, they have higher mortality and morbidity rates. Data regarding risk factors and prevalence of low BMD among African American and Caucasian college-aged women are limited. Purpose. The primary purpose of this research was to explain …
Type 2 Diabetes In Children: Estimates Of Epidemiology, Quality Of Care, Costs And Resource Utilization In A Medicaid Population, Vennela Thumula
Type 2 Diabetes In Children: Estimates Of Epidemiology, Quality Of Care, Costs And Resource Utilization In A Medicaid Population, Vennela Thumula
Electronic Theses and Dissertations
Objective: the primary goal of this study was to assess the current state of diabetes, specifically type 2 diabetes in Mississippi Medicaid enrolled pediatric population. Background: Diabetes is the most prevalent pediatric chronic condition. Recent trends indicate that type 2 diabetes in children is increasing. Epidemiology estimates of type 2 diabetes in children and adolescents are limited. Quality of care and their health care utilization estimates are not available. Methods: 2002 - 2004 Mississippi Medicaid claims data were used for this study. A combination of ICD-9 codes (250.0x - 250.9x, where x=0 or 2) and/or oral hypoglycemic (OHG) drug use …
A Single Case Study Of A Three Year Coordinated School Health Program At A Rural North Mississippi Elementary School, Sandra Lena Howell
A Single Case Study Of A Three Year Coordinated School Health Program At A Rural North Mississippi Elementary School, Sandra Lena Howell
Electronic Theses and Dissertations
The single case study presents the story of the implementation of a three year Coordinated School Health Program (CSHP) at a rural North Mississippi school. The school was recognized by the Mississippi Department of Education, Office of Healthy Schools, as one of ten selected model Mississippi healthy schools. An awarded grant of one hundred thousand dollars funded the implementation of the CSHP over a three year period. The study examined the impact of the CSHP on the students, staff, and personnel. Two types of data were collected and analyzed including archived documents and interviews conducted with five members of the …