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Role Of Jagged1 In The Enrichment Of Cancer Stem Cells In Her2+ Breast Cancer, Deep Shah
Role Of Jagged1 In The Enrichment Of Cancer Stem Cells In Her2+ Breast Cancer, Deep Shah
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Purpose: Breast cancer is the second leading cause of cancer-related deaths among women worldwide. Human Epidermal Growth Factor Receptor 2 (HER2) positive subtype of breast cancer is driven by a subpopulation of cells possessing stem cell properties of self-renewal and differentiation, known as Cancer Stem Cells (CSCs). CSCs are implicated in tumor growth as well as radiotherapy and chemotherapy associated resistance. Notch receptors promote breast CSCs survival and self-renewal, and overexpression of Notch ligand Jagged1 predicts poor prognosis. We showed previously that Notch could be an important target in trastuzumab/lapatinib resistant HER2+ breast cancer.
Experimental Design: Here, we sought to …