Medicine and Health Sciences Commons^™

The Effects Of Maternal Delta-9-Tetrahydrocannabinol And Cannabidiol Exposure On Fetal Heart Development In Mice, Gregory Robinson

Electronic Thesis and Dissertation Repository

Up to 22.6% of pregnant women consume cannabis during pregnancy despite the uncertainty of teratogenicity of the main ingredients in cannabis, delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD). This study tested the hypothesis that gestational THC and CBD exposure leads to heart abnormalities. Daily, oral THC exposure induced heart abnormalities in 68% of offspring with three main phenotypes including thickened semilunar valves, ventricular myocardial hypertrophy and hypoplastic coronary arteries in fetuses, and postnatal cardiac dysfunction. Altered gene expression of key cardiogenic regulators, increased proliferation, and reduced epicardial epithelial-to-mesenchymal-transition were demonstrated implicating potential mechanisms responsible for these abnormalities. Also, maternal CBD exposure resulted …

A Quality Improvement Project To Facilitate A Human Trafficking Screening Protocol At A Maternal Resource Center, Jessica Mcdow

Doctor of Nursing Practice

Human trafficking is a global, criminal industry that negatively impacts the health of victims. Most U.S. victims of human trafficking are young females. Many female sex trafficking victims will seek health care services for unplanned pregnancies and sexually transmitted infections. Healthcare professionals fail to identify human trafficking victims due to lack of standardized screening. The aim of the project was to initiate a sustainable, standardized human trafficking screening protocol at a Maternal Resource Center in order to improve human trafficking identification.

This 10-week quality improvement project provided the staff and volunteers at a Maternal Resource Center with the necessary tools …

Pregnancy Bridge Program For Psychiatric Patients, Adam Barnett

Doctor of Nursing Practice

The National Institute of Mental Health (2017) estimates that 9.2 million people age 18 years and older are diagnosed with bipolar disorder in the United States. Research has shown pregnancies in women with mental health problems have higher rates of poor outcomes and complications (Epstein et al., 2014; Freeman, 2007; Rusner et al., 2016; Scrandis, 2017). Aim. The purpose of this scholarly project is to provide standardized patient education, increase urine human chorionic gonadotropin screening rates, and to set up a gynecologic care bridge for patients considering pregnancy and are diagnosed with bipolar disorder. Evidence. The Centers for …

Quantifying Mid-Pregnancy Placental Metabolism In Guinea Pigs Fed A Lifelong Western Diet, Mary-Ellen E.T Empey

Electronic Thesis and Dissertation Repository

Maternal consumption of a Western diet (WD) has been linked to alterations in fetoplacental metabolic programming and risk for the exposed fetus to develop obesity, cardiovascular disease, and type II diabetes mellitus. It may also cause oxidative damage to the placental mitochondria. This thesis investigated the metabolic effects of a WD on placentae using a guinea pig model of pregnancy and hyperpolarized ¹³C MRI for metabolic quantification. It was hypothesized that placental glycolytic metabolism would increase, and placental oxidative metabolism would decrease in WD-fed sows. Control diet- and WD-fed, pregnant sows underwent metabolic MRI at 33 days gestation and …

A Mixed-Methods Analysis Of Abortion Attitudes And Perceptions Among Women Living In Alabama And South Carolina, Anthony Peluso

Electronic Theses and Dissertations

Legal induced abortion is a safe option for terminating a pregnancy for women of reproductive age in the United States (U.S.), though access has varied since the Roe v. Wade and Doe v. Bolton cases in 1973. Information is lacking on women’s attitudes toward and perceptions of abortion as well as on related constructs such as pregnancy attitudes and contraceptive use. Exploring these constructs is important in that it can provide much needed context to women’s reproductive life planning. This research aimed to explore perceptions of abortion access and safety and examine the potential associations between attitudes toward abortion access …

The Role Of Agency In Early And Unwanted Adolescent Pregnancy: A Multi Country Analysis, Katharine Mccarthy

Dissertations and Theses

Purpose. The agency to decide one’s reproductive future is paramount, yet an estimated 75 percent of adolescent girls in the United States (U.S.) and 49 percent of those in low and middle-income countries experience mistimed or unwanted pregnancy. This dissertation characterized empirical representations of agency over the course of adolescence and investigated the relationship between agency and early and unwanted pregnancy and childbearing using data from three countries (India, Zambia and the U.S.).

Methods. Using latent class and latent transition analysis, multi-dimensional profiles of adolescent agency were assessed using data from: (1) a state representative cross-sectional cohort study of adolescents …

Barriers And Facilitators To Opioid Use Treatment And Recovery Services During Pregnancy, Loralie Woods

Dissertations

Purpose: To identify barriers and facilitators to opioid use treatment and recovery services among pregnant and nonpregnant women who misuse opioids.

Background: Over 130 Americans die daily after overdosing on opioids. Women have not been immune from opioid use disorders (OUDs), with a 4-fold increase from 1999-2010. The prevalence of opioid use among pregnant women increased from 1.5 per 1,000 hospital deliveries to 6.5. Although the annual National Surveys on Drug Use and Health (NSDUH) has provided information on risk factors for OUD related to socioeconomic and demographic factors, no studies using this data have identified barriers to opioid use …

Determining The Knowledge And Practices Of Obstetrics Healthcare Professionals Regarding Maternal Intrapartum Pertussis Vaccination Administration, Kristie Mattix

Doctor of Nursing Practice Scholarly Project

Pertussis is a contagious respiratory disease that can occur in all age groups. Signs and symptoms of pertussis, however, are worse in infants and young children; likewise, the rates of severe cases, hospitalizations, and deaths are higher in this group as well. Vaccination against pertussis is the most effective way to combat this illness. In the last 15 years, there have been a number of changes in the recommendations regarding vaccination against pertussis. In order for these recommendations to be followed, healthcare professionals must be aware of the guidelines as well as be knowledgeable about the condition they are trying …

Socioeconomic Status And Symptoms Of Anxiety And Depression In Pregnant Women, Meagan Mandabach

Honors Theses

Pregnancy is a period of great change in a woman’s body as her baby develops. During this period, women commonly experience symptoms of anxiety (Dennis et al., 2017) and depression (Shidhaye & Giri, 2014). Literature has suggested that socioeconomic status (SES) can contribute to the severity at which pregnant women experience anxiety and depression (Arora & Aeri, 2019; Field et al., 2008; Shagufta & Shams, 2019), and women of low socioeconomic status may be more likely to experience symptoms of anxiety and depression during pregnancy (Field et al., 2008). The present study aimed to assess the relationships between household income …

An Examination Of The Association Between State Medicaid Perinatal Services And Birth Outcomes, Joy Morgan Myers

Honors Theses

This thesis investigated the connection between socioeconomic status, healthcare coverage, and birth outcomes. The research question that was posed specifically looked at twenty perinatal services that states covered under Medicaid to varying degrees to see their association, if any, with premature birth rates and low birthweight rates. State-level and Mississippi county-level data were compiled regarding preterm birth rates, low birthweight rates, presumptive eligibility adoption, and coverage of twenty different perinatal services. Using these data, the correlation between state Medicaid expansion status and birth outcomes was first calculated in order to determine if variation in birth outcomes was associated with expanded …

The Nightmare Before Delivery: A Study Of Nightmares, Depressive Symptoms, And Suicidality In Pregnant Women, Denise Frantz

Honors Theses

Pregnancy is notoriously a time of immense changes. Some of which are characterized by disturbances in sleep such as trouble falling asleep, trouble staying asleep, waking after sleep onset, snoring, leg discomfort, and nightmares (Foley, Ancoli-Israel, Britz, and Walsh, 2004; Lee and Gay, 2004; Köthe & Pietrowsky, 2001). Nightmares specifically have been associated with depressive symptoms and suicidality in non-pregnant individuals (Cukrowicz et al., 2006; Tanskanen et al., 2001), but these relations are not as well understood in the pregnant population. The aim of this study was to assess any potential relation between nightmares and depressive symptoms and suicidality in …

Herpes Zoster In Pregnancy, Kimberly Svidal Rn

Nursing Capstones

No abstract provided.

The Autoimmune System: The Effect Of Physiological Stressors On Autoantibody Glycosylation And Fidelity Of Autoantibody Profiles, Rahil Kheirkhah

Graduate School of Biomedical Sciences Theses and Dissertations

The presence of thousands of autoantibodies (aABs) in the human sera is typical, and therefore it is possible to identify an aAB profile for each individual. In the first part of this thesis, we will show the cerebrospinal fluid also exhibits an extraordinarily complex immunoglobulin G aAB profile that is composed of thousands of aABs. We show that the pattern of expression of individual aABs in CSF closely mimics that in the blood, indicative of a blood-based origin for CSF aABs. In addition, using longitudinal serum samples obtained over a span of nine years, we show remarkable stability in aAB …

Reflection And Literature Review On Loving Choices Pregnancy Center Internship, Madison Stave

The Eleanor Mann School of Nursing Undergraduate Honors Theses

This honors thesis involves a personal reflection and literature review of a nurse internship at Loving Choices Pregnancy Center in Fayetteville, AR. The purpose of this internship was to provide a learning experience in women’s and obstetrical health. Responsibilities included completing community resource projects and assisting staff and nurses in the Care Center and Pregnancy Clinic. To satisfy honors requirements, five learning objectives were created during the internship. These objectives were all met and reflected upon in the first part of this thesis. The second portion of this thesis involves a literature review of the socioeconomic and health-related risks of …

First Trimester Prenatal Screening: Parent Education, Madison Vandiver

Honors College Theses

The healthcare field is constantly evolving, and consequently the ways that medical procedures are done is always changing. Advancements in medicine have made it possible to screen for chromosomal abnormalities earlier and for the screening to be done more accurately than ever before. This is accomplished through a first trimester screening performed between 11- 13 weeks gestation of the pregnancy. With this screening becoming more integrated into routine prenatal care and being offered to various women with a range of risk factors, it is important to offer many educational opportunities about the screening procedure. Provision of education to patients interested …

Relation Of Flt-1 And Endothelial Function In Women Soon After Delivery: Effect Of Physical Activity And Sedentary Behavior, Chloe W. Caudell

Senior Theses

Adverse pregnancy outcomes (APOs) are believed to be caused by poor placental formation. APOs can be characterized by elevated levels of a circulating Fms-like tyrosine kinase biomarker called Flt-1, produced by the placenta when its blood vessels are shallow or inadequately formed. Flt-1 acts directly on the maternal endothelium to impair vascular function during pregnancy and contributes to maternal features of APOs. This study aimed to evaluate the relation of Flt-1 and endothelial function in women soon after delivery. This study also aimed to evaluate the relation of Flt-1 and physical activity and sedentary behavior in women during and soon …

Risk Factors For Poor Birth Outcomes In Moderately Malnourished Pregnant Women In Sierra Leone, Candice A. Rodriguez

Master's Theses

Background: Maternal malnutrition in developing countries is associated with adverse pregnancy and birth outcomes. Malnourished mothers are often faced with additional risk factors as a circumstance of poverty. Supplementary nutrition can improve the outcomes of both mother and infant. Identifying maternal nutritional and socioeconomic risk factors is critical for developing effective interventions.

Objective: A secondary analysis to evaluate maternal risk factors associated with poor birth outcomes including pregnancy loss, low birth weight, stunting, and preterm delivery among moderately malnourished pregnant women in Sierra Leone. Maternal risk factors in the analysis are age, education, parity, BMI, MUAC, gestational weight gain, and …

Does Gestational Diabetes Mellitus Increases The Risk Of Preeclampsia Among Primigravid Women?, Astha Kakkad

USF Tampa Graduate Theses and Dissertations

Gestational diabetes mellitus (GDM) and preeclampsia are serious complications of pregnancy which are associated with both short- and long-term adverse health outcomes for the mother as well as the fetus. The increase in prevalence of these conditions has become a major public health concern. The purpose of this study is to examine the association and risk imposed by GDM for preeclampsia in primigravid women. This descriptive study was conducted using data retrieved from the electronic medical records of a large integrated health system in Florida. The data for this analysis included pregnancy records for patients at least 18 years of …

Marijuana Use In Pregnancy And The Effects On The Fetus/Infant, Amy Rebecca Hurst, Malia Smylie

All Electronic Theses and Dissertations

The purpose of this paper is to critically examine the literature and evidence that is available surrounding pre-pregnancy and prenatal use of marijuana and the effects it has on the developing fetus/infant. It was found that across most findings that further research needs to be done on the use of marijuana prior to pregnancy, during pregnancy, and postpartum. It has also been found that screening and counseling needs to be done and focused on prior to pregnancy and during pregnancy and postpartum. Healthcare professionals have the opportunity to establish a trusting relationship with their patients and to be able to …

Challenges And Promising Strategies For Maximizing Pregnant Women's Adherence And Retention In Niv Care In The Context Of Option B+ In Kenya, Anna Helova

All ETDs from UAB

Under the current Kenyan guidelines, pregnant/postpartum women who test HIV-positive are immediately put on the lifelong antiretroviral (ART) therapy (Option B+) and are initiated into the prevention of mother-to-child (PMTCT) protocol. Gaps at each step of the PMTCT continuum undermine the positive impact of lifelong ART. Challenges at the individual, interpersonal, community, and health facility-levels contribute to these gaps. A community-based mentor mother (cMM) program tested under the Mother-Infant Visit Adherence and Treatment Engagement(MOTIVATE!) Trial (NICHD R01 R01HD080477; ClinicalTrials.gov#14-0331) is a potential approach to address these challenges. The three manuscripts comprising this dissertation used qualitative and quantitative methods with the …

The Association Of Maternal Sociodemographic Factors With Stress In Pregnancy, Maheshwari Andhavarapu

Theses & Dissertations

Introduction: Antenatal stress has been linked to maternal morbidity and preterm birth (PTB). One of the pathophysiological processes leading to PTB is thought to be via activation of the hypothalamus-pituitary-adrenal axis resulting in cortisol production. Hair cortisol has recently been shown to be a stress marker in the pregnant and non-pregnant population. Some determinants of hair cortisol have also been studied but more research is needed in this area, especially in pregnancy. Understanding the risk factors of antenatal stress may guide institution of preventative or screening measures to reduce the risk of adverse birth outcomes. As the effect of stress …

Non-Pharmacological Interventions For Alcohol, Marijuana, And Opioid Use During Pregnancy: A Systematic Review, Hannah Safranek, Madeline Frausto, Amy King, Stoneking Madison

Williams Honors College, Honors Research Projects

The purpose of this review is to analyze evidence on prevalence of opioid, alcohol and marijuana use during pregnancy and answer the PICOT question: In pregnant women addicted to or using marijuana, opioids, and alcohol, how do non-pharmacological interventions, compared to standard care of pharmacological interventions alone, affect health outcomes in mothers and neonates between birth to hospital discharge? Diagnosis of substance use disorder is increasing and with it comes increased risk of complications to mother and neonate including neonatal abstinence syndrome (NAS), fetal alcohol syndrome (FAS) and other negative neonatal and maternal outcomes. Evidence was identified on the online …

Cardiovascular Tissue Remodeling Of Preeclampsia, Rachel Metz

Williams Honors College, Honors Research Projects

Preeclampsia is a hypertensive disorder of pregnancy that leads to a multitude of problems for the mother and fetus during and after pregnancy. While the effects on the mother's body after pregnancy are often overlooked, preeclamptic mothers are prone to cardiovascular diseases from the great deal of stress experienced through the duration of a preeclamptic pregnancy. The associated high blood pressure causes cardiac muscle to work a great deal harder in an attempt to successfully perfuse tissues adequately. This increase in prolonged stress leads to remodeling of the cardiovascular tissues-significantly increasing the risk of heart issues in life beyond the …

Impact Of Lifestyle Factors On Group B Streptococcus Colonization During Pregnancy, Myra Joy Quilatan

Theses

Background: Group B Streptococcus (GBS) colonization in the genital tract of pregnant women is a known contributory factor for infection in the neonate, having an impact on morbidity and mortality especially if unrecognized and untreated prior to vaginal delivery. An understanding on how certain lifestyle factors contribute to the development of GBS colonization during pregnancy will assist in aiding a modification of behavior to promote prevention and improve general health.

Aim: The aim of this study was to investigate the effect of various lifestyle factors in isolation or combination on GBS colonization during pregnancy.

Methods: A cross-sectional survey research design …

Cardiac Effects Of Obesity During Pregnancy In C57bl/6j Mice, Kayla Lynn Dudick

Theses and Dissertations--Nutrition and Food Systems

Objective: Pregnancy requires profound cardiac and metabolic adaptation. Left ventricular (LV) mass is increased in response to pregnancy, but is not associated with cardiac damage. In contrast, obesity-mediated cardiac hypertrophy is pathological. Data from animal studies indicate dietary fatty acid composition may have a protective effect during states of extreme cardiac physiological adaptation. In contrast, aberrant cardiac metabolism is a hallmark of disease. Over a third of reproductive-age women in the United States are obese, but there is a paucity of data describing the effect of obesity on maternal cardiac adaptation to pregnancy. The objective of this study was to …