Medicine and Health Sciences Commons^™

Is Phentermine/Topiramate Er With Lifestyle Modifications Effective In Achieving Weight Loss In Obese Patients With Comorbidities?, Elizabeth A. Stubbs

PCOM Physician Assistant Studies Student Scholarship

Objective: The objective of this selective EBM review is to determine whether or not “Is phentermine/topiramate ER with lifestyle modifications effective in achieving weight loss in obese patients with comorbidities?”

Study Design: A systematic review of three placebo-controlled randomized controlled trials (RCTs) published in English in 2012 or after.

Data Sources: All three studies were found by searching PubMed and were published in peer-reviewed journals. The articles were selected based on ability to answer the proposed question.

Outcome Measured: Percent weight loss was the outcome measured in all three studies. This was measured based on mean percent weight loss from …

Do Adult Obese Patients Who Undergo Sleeve Gastrectomy Have A Greater Increase In Quality Of Life Compared To Those Who Undergo Gastric Bypass?, Jenna Loeser

PCOM Physician Assistant Studies Student Scholarship

OBJECTIVE: The objective of this selective EBM review is to determine whether or not obese patients have a better quality of life after undergoing gastric bypass rather than sleeve gastrectomy.

STUDY DESIGN: A review of 3 randomized controlled trials (RCT) that were published after 2014.

DATA SOURCES: The 3 peer-reviewed randomized controlled trials were found through PubMed. All studies were published in English.

OUTCOMES MEASURED: The outcome measured in these RCTs was overall change in quality of life after sleeve gastrectomy and gastric bypass. This was done by patients responding to questionnaires. Two articles Ignat et al. and Peterli et …

Is Weight Loss An Effective Treatment Of Pain Symptoms Related To Knee Joint Osteoarthritis In Obese Adults?, Samantha Sokol

PCOM Physician Assistant Studies Student Scholarship

Objective: The objective of this selective EBM review is to determine whether or not weight loss is an effective treatment of pain symptoms related to knee joint osteoarthritis in obese adults.

Study Design: Systematic review of 2 randomized-controlled trials and 1 cohort study. All three articles were published in English between 2011-2015.

Data Sources: Two randomized, un-blinded, controlled studies and one cohort found using Pubmed.

Outcomes Measured: Each study evaluated change in pain symptoms related to knee osteoarthritis in obese adults as compared to weight loss.

Results: Studies showed that weight loss lead to a …

Novel Anti-Obesity Effects Of Beer Hops Compound Xanthohumol: Role Of Ampk Signaling Pathway, Janaiya S Samuels

PCOM Biomedical Studies Student Scholarship

Obesity, a chronic disease, is a global epidemic that affects millions of lives and increases the risk of several comorbidities such as Type 2 diabetes, musculoskeletal disorders, cardiovascular disease, and cancer. Obesity is the leading cause of death globally, and is associated with an excessive accumulation of white adipose tissue (WAT). Although obesity is a serious condition, safe, long-term drug therapies are limited. A second type of adipose tissue is known as brown adipose tissue (BAT), which functions as an energy dissipater in the form of heat, as opposed to energy storing WAT. Previous research has shown that the mitochondrial …

Are Soy-Based Proteins, Meals, And Diets An Effective Treatment In Reducing Waist Circumference In Overweight And Obese Adults Ages 20-75 Years?, Lisa Lin

PCOM Physician Assistant Studies Student Scholarship

Objective: The objective of this evidence based medicine review is to determine whether or not soy-based proteins, meals, and diets are effective treatments in reducing waist circumference in overweight and obese adults ages 20-75 years.

Study design: Review of three published, randomized controlled trials (RCTs) published in 2003, 2007, and 2011. All English language.

Data Source: The three randomized controlled trials that used in this review were found using PubMed.

Outcomes measured: The outcomes measured were improvement of patient’s overweight and obesity status and their overall quality of life through the indication of reduced waist circumference. …

Are New Sodium Targets In The National School Lunch Program Feasible And Are They Necessary?, Yaneve Shemesh

PCOM Biomedical Studies Student Scholarship

In many societies, high salt intake is a continuing issue in adults, and is of growing concern in children due to the prevalence of processed foods. In response, the USDA has set three targets for sodium in meals offered in the National School Lunch Program (NSLP), and the National School Breakfast Program (NSBP). This 8-year goal is meant to decrease overall sodium levels in both meal programs. However, many associated with school nutrition ask if there is significant evidence to show what effect sodium plays on children’s health, and thus determine if these targets are necessary or achievable. In addressing …

Is Laparoscopic Gastric Banding An Effective Treatment For Obesity In Adolescents And Adults As Measured By Physical Function?, Shawna Mccormick

PCOM Physician Assistant Studies Student Scholarship

OBJECTIVE: The objective of this selective EBM review is to determine whether or not “Is laparoscopic gastric banding an effective treatment for obesity in adolescents and adults as measured by physical functioning?”

STUDY DESIGN: Review of all English language primary studies from 2009, 2010, and 2011.

DATA SOURCES: Two randomized control trials and one cohort study were found using PubMed, Medline, and OVID.

OUTCOMES MEASURED: There were multiple outcomes measured in the studies but the outcome of concern is quality of life post-operatively, specifically, physical functioning as measured by surveys including SF-36, Moorehead-Ardelt, BAROS, and CHQ CF-50. …

Does The Use Of Ginger Extract Effectively Help Patient With Obesity Loses Weight?, Linh H. Nguyen

PCOM Physician Assistant Studies Student Scholarship

Objective: The objective of this selective EBM review is to determine whether or not ginger extract (NT) effectively helps obese patient loses weight.

Study Design: Two randomized controlled studies to determine the effectiveness of ginger extract in weight loss and a cross sectional observational study.

Data Sources: Randomized controlled studies published after 2006 relating to ginger extract (NT) and weight loss. Data obtained using PubMed, CINAHL, and OVID databases written in English.

Outcomes Measured: Studies measured weight loss, food intake, and safety such as pulses and blood pressure. Subjects are evaluated at baseline with CMP, CBC and urinalysis weekly.

Results: …

Does The Use Of An Oral Lipase Inhibitor (Orlistat) Increase Appetite?, Sandra Boyd

PCOM Physician Assistant Studies Student Scholarship

OBJECTIVE: To determine whether or not Orlistat ingested prior to a meal causes an increased appetite response.

STUDY DESIGN: A Review of three randomized controlled trials studies from 2003-2008 that were in the English language.

DATA RESOURCES: Randomized controlled trials comparing the effect of Orlistat on satiety were found using PubMed, OVID, and Cochrane databases.

OUTOMES MEASURED: Outcomes measured in the studies were: sensation of appetite, hunger, fullness, nausea, bloating, heartburn, belching, epigastric burning, and prospective food consumption. Each study measured individual patient responses using a VAS (visual analogue scale). Demarchi et al (2004) used a gastric barostat to measure …

Is White Bean Extract A Safe And Effective Treatment For Weight Loss?, Jamie Berkowitz

PCOM Physician Assistant Studies Student Scholarship

Objective: The objective of this systematic review is to determine whether or not white bean extract is a safe and effective treatment for weight loss.

Is Growth Hormone An Effective Adjunct To Standard Treatment Regimens For Promoting Fat Mass Loss And Retention Of Lean Body Mass In The Treatment Of Obesity?, J. Caleb Henson

PCOM Physician Assistant Studies Student Scholarship

Objective: The objective of this systematic review is to determine whether growth hormone is an effective adjunct in the treatment of obesity for promoting fat loss while retaining lean body mass.

Does Caffeine Consumption Effect Exercise Performance In Healthy Adults?, Meaghan E. Jones

PCOM Physician Assistant Studies Student Scholarship

OBJECTIVE: The objective of this systematic review is to determine whether or not caffeine ingestion prior to exercise effects exercise performance in healthy adults.

Is Liraglutide Safe And Effective As A Monotherapy For The Treatment Of Obesity In Type 2 Diabetics And Healthy Individuals?, Erica Sheeran

PCOM Physician Assistant Studies Student Scholarship

OBJECTIVE: The objective of this systematic review is to determine whether or not liraglutide is safe and effective as a monotherapy for the treatment of obesity in type 2 diabetics and healthy individuals.