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- Lung Cancer (2)
- Activity monitor accuracy; Lower-limb amputees; Comorbidity reduction; Pedometers - Placement (1)
- And Enrichment Program; iRelate Program; Family Resilience Model; Life-Cycle Perspective; Actor Partner Interdependence Models (1)
- Ankle Sprains; Musculoskeletal Injuries; Postural Stability (1)
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- Coping Strategies; Problem solving; Burnout; Depression (1)
- Diagnostic imaging modalities; Tooth length measurements; MRI tooth length measurements; CBCT scans (1)
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- Euclidean Distance Matrix analysis; Statistical Shape Model; Digital Imaging and Communications in Medicine; (1)
- Flaviviruses; Southern California; Rattlesnakes; (1)
- Forward head posture (1)
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- Guided Dental Implant Delivery System; Implant placement; (1)
- HUD; Hierarchical Linear Modeling; Socioeconomic Status; Resilience (1)
- Headscarf; Hijab; Proprioception; Joint Position Error Test; Mobility (1)
- Immunosuppressive Cytokines; Biosynthesis; Immunological Tolerance; (1)
- Intimate Partner Relationships; Relational Conflict; Emotion Regulation; Conflict Resolution; (1)
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- Legally-minded Therapists; Legal education; Personal legal skills; Legally-competent Therapists (1)
- Lens epithelium-derived growth factor (1)
- Magnet Hospitals; Non-magnet Hospitals; Professional fidelity; Patient satisfaction; Patient empowerment; (1)
- Moment Dissociation Point; Six-degree of freedom load cell; Force systems; (1)
Articles 1 - 30 of 37
Full-Text Articles in Medicine and Health Sciences
Behavioral Ecology And Associated Virology Of Mosquito-Host Interactions In Southern California, Oliver Eshun
Behavioral Ecology And Associated Virology Of Mosquito-Host Interactions In Southern California, Oliver Eshun
Loma Linda University Electronic Theses, Dissertations & Projects
Elucidating characteristics of mosquito-host interactions are critical for understanding the ecology and epidemiology of mosquito-borne diseases. In this dissertation, I conducted three studies to explore potential mosquito-host interactions and associated virus infection rates. I first demonstrated that mosquito captures at CO2-baited traps decreased most markedly with height above ground, and also decreased with distance from water at a riparian area but not at an open water source lacking a vegetated border. Birds might therefore prefer elevated nests or roosts to avoid mosquitoes. The second study examined the anti-mosquito behaviors of budgerigars (Melopsittacus undulatus) in a laboratory study. The birds defended …
Parenting Stress And Emotion Dysregulation In Children With Dd: The Role Of Parenting Behaviors, Neilson Chan
Parenting Stress And Emotion Dysregulation In Children With Dd: The Role Of Parenting Behaviors, Neilson Chan
Loma Linda University Electronic Theses, Dissertations & Projects
Parents of children with developmental delays (DD) report higher levels of parenting stress compared to parents of typically developing children. High levels of parenting stress have been associated with negative outcomes for their children, including higher levels of emotion dysregulation. However, this relationship between parenting stress and child emotion dysregulation has rarely been examined in families of children with DD. Additionally, the mechanisms through which parenting stress influences child emotion dysregulation remain unclear; it may be that parenting stress impacts parenting behaviors (i.e., sensitive and intrusive parenting), which in turn influence the development of the child’s emotion regulatory abilities. In …
A Comparison Of Neuromuscular Control Between Subjects With And Without Chronic Ankle Instability, Hatem Jaber
A Comparison Of Neuromuscular Control Between Subjects With And Without Chronic Ankle Instability, Hatem Jaber
Loma Linda University Electronic Theses, Dissertations & Projects
Ankle sprains are common and potentially disabling musculoskeletal injuries occur among physically active individuals. A subsequent problem that is commonly encountered by clinicians due to ankle sprains is the development of ongoing instability. The presence of ankle instability has been linked to impairments in postural and neuromuscular control; however, inconsistent findings have been reported. These discrepancies deem the need to further investigate and provide additional knowledge regarding postural and neuromuscular control strategies utilized by this population. This may enhance the current understanding of chronic ankle instability (CAI) and help to understand how rehabilitation can be customized to specifically target and …
Endothelin-1 And Hypoxic Vascular Remodeling In Ovine Fetal Cerebral Arteries, Jinjutha Silpanisong
Endothelin-1 And Hypoxic Vascular Remodeling In Ovine Fetal Cerebral Arteries, Jinjutha Silpanisong
Loma Linda University Electronic Theses, Dissertations & Projects
Intrauterine hypoxia resulting from decreased maternal oxygen uptake, insufficient oxygen carrying capacity, or compromised oxygen delivery to the fetus jeopardizes fetal oxygen delivery, detrimentally affecting growth and development of the immature vasculature. Hypoxia transiently increases Hypoxia Inducible Factor-1α (HIF- 1α), which complexes with HIF-1β to form the active HIF-1 dimer that can affect transcription. This temporary rise in HIF-1 can promote gene transcription of ligands such as Vascular Endothelial Growth Factor (VEGF) and Endothelin-1 (ET-1), which rises and falls with HIF levels. The absence of chronic elevation of these ligands prompted the question of how long-term effects of hypoxia is …
The Substance Abuse Treatment Experience Of Men Who Have Sex With Men, Scott Sanford Johnson
The Substance Abuse Treatment Experience Of Men Who Have Sex With Men, Scott Sanford Johnson
Loma Linda University Electronic Theses, Dissertations & Projects
The following qualitative research study focuses on the substance abuse treatment experiences of men who have sex with men. Current research in this area indicates that while these men sometimes seek treatment for substance abuse issues, their treatment experience can be compromised due to personal fears or ignorance on the part of treatment staff members or others in treatment (Cabaj, 2008; Cheng, 2003; Hellman, Stanton, lee, Tytun, & Vachon, 1989). Specific goals of this study include: (1) gaining insight into the treatment experience(s) of these men and (2) learning about how their individual and collective treatment experience(s) contribute to their …
Comparison Of Antibacterial Activity Of Ozonated Olive Oil And Chlorhexidine Gluconate, Changmin Lee
Comparison Of Antibacterial Activity Of Ozonated Olive Oil And Chlorhexidine Gluconate, Changmin Lee
Loma Linda University Electronic Theses, Dissertations & Projects
Aim: The aim of this in vitro disk diffusion susceptibility test is to compare the antibacterial activity of ozonated olive oil (OzOO) with chlorhexidine gluconate (CHX) against periodontal pathogens, Porphyromonas gingivalis and Aggregatibacter Actinomycetemcomitans. Materials and Methods: The antibacterial activity of two antiseptics, OzOO and CHX, and, two controls, olive oil and normal saline was assessed by disk diffusion susceptibility test. For disk diffusion susceptibility test, two periodontal pathogens, 20 petri dishes for P. gingivalis and 18 petri dishes for A. actinomycetemcomitans, were used. To assess the antibacterial activity, the diameters of the growth inhibition zone were measured with a …
Comparison Of Tooth Length Measurements Made On Cbct And 3t Mr Images, Danielle A. Piano
Comparison Of Tooth Length Measurements Made On Cbct And 3t Mr Images, Danielle A. Piano
Loma Linda University Electronic Theses, Dissertations & Projects
Objective: The aim of this study is to compare tooth length measurements made on cone beam computed tomography (CBCT) scans and 3-Tesla (3T) magnetic resonance (MR) scans. Materials and Methods: One CBCT scan (NewTom5G, AFP Imaging, USA) and one 3T MR scan (Siemens Medical Solutions, DE) as performed on 12 subjects. CBCT images were captured with an 18x16 inch field of view that covered the whole head. Contiguous sagittal MR images of the whole head were produced in a 3.0T imaging system with a T1-weighted 3D imaging sequence (Magnetization Prepared Rapid Acquisition by Gradient Echo (MP-RAGE), TP/TE = 1950/2.26 ms) …
Prediction Of Root Form Using Crown Data: Mandibular Left First Premolar, Matthew E. Durschlag
Prediction Of Root Form Using Crown Data: Mandibular Left First Premolar, Matthew E. Durschlag
Loma Linda University Electronic Theses, Dissertations & Projects
Introduction: The purpose of this study was to determine if a statistical shape model (SSM) of the lower left first premolar, consisting of both crown and root data, could adequately describe the root form from a surface scan consisting of only crown data. Secondly, it tested if there were any angles or measurements on the tooth crown that correlate with any aspects of root morphology. The average orthodontist practicing today or in the near future is likely to use or own a digital intraoral scanner in their office. Yet optical scans only allow visualization of the crowns of teeth and …
The Effects Of Wearing Headscarves On Cervical Spine Proprioception And Range Of Motion, Samiah Alqabbani
The Effects Of Wearing Headscarves On Cervical Spine Proprioception And Range Of Motion, Samiah Alqabbani
Loma Linda University Electronic Theses, Dissertations & Projects
Background: Wearing the headscarf is a part of an essential religious practice by females in Islamic cultures. Regular wear of the headscarf might have an influence on cervical proprioception and range of motion (ROM). The cervical spine is unique in providing multidirectional movement as well as providing the sense of awareness of movement of the head and neck in space. Impairments in cervical mobility and proprioception have been reported in subjects with whiplash-associated disorder as well as subjects having neck pain. Objectives: 1) To determine the effects of wearing the headscarf on cervical spine ROM and joint position error …
Factors Associated With Orthodontically Induced Apical Root Resorption Of Maxillary Incisors, Brandon Malan
Factors Associated With Orthodontically Induced Apical Root Resorption Of Maxillary Incisors, Brandon Malan
Loma Linda University Electronic Theses, Dissertations & Projects
Introduction: Resorption of root apices is a ubiquitous occurrence in orthodontic treatment. Although most occurrence of resorption during orthodontic treatment is clinically inconsequential, a small percentage of patients have a severe amount of root structure that is lost. There are factors that are widely accepted as responsible for apical root resorption (RR), such as heavy compressive forces on the periodontal ligament (PDL). Unfortunately, it is still largely unpredictable if one patient will experience more root loss than what is considered normal. Thus, it is of clinical interest to further study what factors play a role in RR. Purpose: The purpose …
The Role Of Vegf And Smooth Muscle Phenotype In Hypoxic Remodeling Of Ovine Carotid And Cerebral Arteries, Margaret C. Hubbell
The Role Of Vegf And Smooth Muscle Phenotype In Hypoxic Remodeling Of Ovine Carotid And Cerebral Arteries, Margaret C. Hubbell
Loma Linda University Electronic Theses, Dissertations & Projects
Arteries are a dynamic tissue with multiple cell types that incorporate systemic and local factors to maintain homeostasis. Hypoxia stimulates capillary angiogenesis to effectively match metabolic demand with perfusion. With chronic hypoxia, vascular remodeling of even large vessels can occur. This predisposes to pathologic states as seen with atherosclerosis, hypoxic brain injury, myocardial ischemia, diabetes, and developmental anomalies. With this remodeling comes changes in vessel structure including medial thickness and organization of contractile proteins as well as changes in myogenic tone. All of these factors culminate in changes in status or behavior of the vascular smooth muscle within the vessel …
Effects Of Wire Material, Deflection, And Interbracket Distance On Burstone Bracket Geometry Force Systems, Skyler J. Liatti
Effects Of Wire Material, Deflection, And Interbracket Distance On Burstone Bracket Geometry Force Systems, Skyler J. Liatti
Loma Linda University Electronic Theses, Dissertations & Projects
Objective. This paper aims to quantify the effect of wire material, dimension, and deflection on the most identifiable feature of the six-geometries: the moment dissociation point (force system with no moment on the lesser angled bracket), which may or may not occur at the classically defined geometry IV. Materials and Methods. A six-degree of freedom load cell was used to measure the force systems in different combinations of wire materials, wire dimensions, total angle of bracket, and interbracket distance. Brackets were progressively rotated through Burstone and Koenig’s six geometries and the moment on the right bracket was plotted against the …
Effect Of Extracellular Survivin And Lymphoma Exosomes On Natural Killer Cells, Heather R. Ferguson Bennit
Effect Of Extracellular Survivin And Lymphoma Exosomes On Natural Killer Cells, Heather R. Ferguson Bennit
Loma Linda University Electronic Theses, Dissertations & Projects
Tumors alter their microenvironment to promote survival using methods such as angiogenesis promotion, growth signals, and immune suppression. The immune system becomes unresponsive to transformed neoplastic cells through a variety of methods including T cell suppression, increased myeloid-derived suppressor cells (MDSCs), and reduced natural killer (NK) cell activity. NK cells have inherent killing capabilities and thus are among the first responders in recognizing and destroying abnormal cells. However, many types of cancers inhibit the surveillance and cytotoxic abilities of NK cells by releasing exosomes, vesicles that can modulate the tumor microenvironment (TME) and intercellular communication for the purpose of enhancing …
The Effects Of Frequent Smartphone Use On Children’S Upper Posture And Pulmonary Function, Asma Alonazi
The Effects Of Frequent Smartphone Use On Children’S Upper Posture And Pulmonary Function, Asma Alonazi
Loma Linda University Electronic Theses, Dissertations & Projects
Children are experiencing an increase in sedentary lifestyle as a result of the rising utilization of technology, i.e. smartphones. With the prolonged use of smartphones, increased concerns have been raised regarding constant neck flexion, neck movements limitation, and decreases in pulmonary function due to potential changes in spinal posture. Therefore, the purpose of this research thesis was to evaluate changes in craniovertebral angles (CVA), cervical range of motion (ROM), and pulmonary function among boys and girls 8 to 13 years of age who use smartphones. A cross-sectional study was conducted on a sample of 50 participants (24 boys and 26 …
A Retrospective Lateral Cephalometric Growth Study Of Sagittal Airway Changes, Grace H. Woo
A Retrospective Lateral Cephalometric Growth Study Of Sagittal Airway Changes, Grace H. Woo
Loma Linda University Electronic Theses, Dissertations & Projects
Purpose: This study retrospectively examined the average sagittal dimensions in the pharyngeal airway from skeletal and dental Class I males and females from 7 to 16 years of age utilizing longitudinal data from the American Association of Orthodontists Foundation Craniofacial Growth Legacy Collection. The study evaluated whether average sagittal airway dimensions differed between males and females at each age, and whether the sagittal airway dimension changed with increasing age. Materials and Methods: Sagittal airway dimension based on identifiable anatomical landmarks were digitally traced and measured from the longitudinal lateral cephalograms of 30 females and 32 males from the AAOF Growth …
Effects Of Head Motion On Postural Stability In Participants With Chronic Motion Sensitivity, Abdulaziz A. Albalwi
Effects Of Head Motion On Postural Stability In Participants With Chronic Motion Sensitivity, Abdulaziz A. Albalwi
Loma Linda University Electronic Theses, Dissertations & Projects
Background: Motion sensitivity, or motion sickness, is common among individuals in modern vehicular and visually stimulating environments; notably, people with normal vestibular function are susceptible to this condition. Motion-provoked dizziness often causes postural instability. Purposes: This study aimed to compare the effects of head motion on postural stability in healthy adults with and without chronic motion sensitivity (CMS) and to determine the effects of head motion direction (horizontal versus vertical) on postural stability. Methods: Sixty healthy adult males and females aged 20 to 40 years old were assigned to two groups, 30 participants with CMS and 30 participants without CMS. …
Accuracy Of A Newly Developed Guided Dental Implant Delivery System, Fallon D. Livingston
Accuracy Of A Newly Developed Guided Dental Implant Delivery System, Fallon D. Livingston
Loma Linda University Electronic Theses, Dissertations & Projects
Purpose: The purpose of this study was to evaluate the accuracy of a guided dental implant system with one operator comparing the treatment planned location to the actual location using a table top optical scanner. Materials and Methods: Twenty five patients were treated with a cone beam computed tomography (CBCT) scan. A stone cast was made of each patient and scanned using an optical table top scanner. The optical scan of the cast and the CBCT of the patient were superimposed and a single implant was placed virtually in the software program. A sterolithographic three dimensional (3D) surgical guide was …
Activity Monitor Accuracy For Lower-Limb Amputees Living In Colombia And Texas, Gary Guerra Briseno
Activity Monitor Accuracy For Lower-Limb Amputees Living In Colombia And Texas, Gary Guerra Briseno
Loma Linda University Electronic Theses, Dissertations & Projects
Maintaining physical activity for lower limb prosthesis wearers is important in order to reduce comorbidities and decrease physical function. Activity monitors can provide motivation for the wearer and outcome measurements for the health care professional. Two cohorts of lower extremity amputees participated in two separate studies examining the accuracy of activity monitors. Each participant completed a 200m walking trial while activity monitors were fitted to them and step counts were compared with actual counts. For participants walking on even ground in a developing setting no significant differences between pedometer and actual counts were found, nor were there significant differences with …
Prenatal Undernutrition, Metyrapone, And The Cerebrovasculature, Lara Durrant
Prenatal Undernutrition, Metyrapone, And The Cerebrovasculature, Lara Durrant
Loma Linda University Electronic Theses, Dissertations & Projects
The link between intrauterine environmental conditions and adult cardiovascular system is well established. Independent of lifestyle factors such as poor diet and exercise habits, individuals who have been exposed to stressful conditions in utero show an increased risk of health problems such as hypertension, stroke, and type II diabetes. In support of the Fetal Origin of Adult Disease hypothesis, many labs have reported permanent anatomical and physiological changes associated with fetal stress and nutrient deficiency, with a focus on organ systems such as the kidney and heart. One key idea proposed by many of these studies is the glucocorticoid hypothesis, …
Targeting Ledgf/P75 To Sensitize Chemoresistant Prostate Cancer Cells To Taxanes, Leslimar Rios-Colón
Targeting Ledgf/P75 To Sensitize Chemoresistant Prostate Cancer Cells To Taxanes, Leslimar Rios-Colón
Loma Linda University Electronic Theses, Dissertations & Projects
Prostate cancer (PCa) is the second most diagnosed cancer in males. This disease disproportionately affects African American men, with a higher incidence and mortality compared to other ethnic/racial groups. An aging male population and the complexity of addressing the health disparities associated with this disease puts PCa into the spotlight due to its serious public health implications and the imminent fiscal challenge over the next decades. Chronic prostate inflammation resulting in activation of stress and prosurvival pathways contribute to disease progression and the development of chemoresistance. Lens epithelium-derived growth factor p75 (LEDGF/p75) is a stressresponse protein that promotes cellular survival …
A Novel Population Of Cardiovascular Progenitors Persist In Neonates As Mesendodermal Cells, Julia Kim
A Novel Population Of Cardiovascular Progenitors Persist In Neonates As Mesendodermal Cells, Julia Kim
Loma Linda University Electronic Theses, Dissertations & Projects
The rise in mortality due to cardiovascular disease has increased the need to develop an efficient regenerative therapeutic for heart failure. Numerous cell-based therapies have been investigated for myocardial regeneration; however, an optimal progenitor has yet to be discovered. Identifying a resident cell population with enhanced ability to differentiate into multiple lineages would greatly contribute to the field of stem cell-based regenerative therapy. Evidence suggests that endogenous cardiovascular progenitor cells (CPCs) that have been isolated from the heart itself express ISL1, KDR, and MESP1, and are capable of differentiating into all major cardiac lineages. The earlier developmental stage at which …
Relationship Between Vestibular System, Vision, Anxiety, And Chronic Motion Sensitivity, Ahmad A. Alharbi
Relationship Between Vestibular System, Vision, Anxiety, And Chronic Motion Sensitivity, Ahmad A. Alharbi
Loma Linda University Electronic Theses, Dissertations & Projects
BACKGROUND: Chronic motion sensitivity (CMS) has been defined as a feeling of un-wellness elicited by either actual or perceived motion. CMS is a common condition and is more prevalent in females than in males. In addition to a variety of symptoms, young adults with CMS have less postural stability than those without CMS. OBJECTIVE: To determine whether vestibular system integrity, dependence on visual cues for postural stability, and the anxiety level are different between young adults with and without CMS, and whether it differs by gender within each group. METHODS: Sixty young adults (30 females and 30 males) were assigned …
Cancer Center Regional Benchmarks For Psychosocial Care, Desiree R. Azizoddin
Cancer Center Regional Benchmarks For Psychosocial Care, Desiree R. Azizoddin
Loma Linda University Electronic Theses, Dissertations & Projects
The American College of Surgeons (ACoS) Commissions on Cancer (CoC) formulated and implemented standard 3.2 for Psychosocial Distress Screening. This standard requires that all accredited cancer centers evaluate psychosocial distress and provide appropriate triage and intervention for all cancer patients. Over the past decade, Loma Linda University Medical Oncology Center (LLUMOC) administration, physicians, nurses, psychosocial care staff, and chaplaincy collaborated to implement a psychosocial screening and referral program throughout cancer patient services. This current research includes qualitative analysis assessing strengths and barriers of the psychosocial program at LLUMOC from the perspective of LLUMOC providers and two directors of Supportive Care …
Living On Borrowed Time: A Longitudinal Examination Of A Time-Limited Housing Voucher Program, Lauren D. Foster
Living On Borrowed Time: A Longitudinal Examination Of A Time-Limited Housing Voucher Program, Lauren D. Foster
Loma Linda University Electronic Theses, Dissertations & Projects
There are a number of families currently living in poverty across the United States (Census, 2010). These families are often stressed and spread thin in their daily lives. Different governmental supports are used to bolster individuals and families during their experiences of poverty. One such entity is the United States Department of Housing and Urban Affairs (HUD). This agency provides housing to countless residents each year (HUD, 2016). Much is known about the different program that HUD offers but information is limited what strengths families can bring in that can aid in their experiences while living in poverty. Using Hierarchical …
The Lived Experience Of Retention And Progression Of Black/African American Nursing Students, India Mylon Medley
The Lived Experience Of Retention And Progression Of Black/African American Nursing Students, India Mylon Medley
Loma Linda University Electronic Theses, Dissertations & Projects
Despite recent strides to increase workforce diversity, nurses continue to inadequately reflect the ethnic composition of the population they serve. To effectively answer the national calls for increased diversity in the nursing workforce, there must be a greater representation of minority students studying nursing. However, minority nursing students, especially those of Black/African American descent, have less access to nursing education, poorer retention and progression rates in nursing programs, and are more likely to withdraw from programs. The existence of an increasingly diverse nursing workforce depends upon the recruitment, retention, progression, and graduation of minority students. Whereas Historically Black Colleges and …
Effect Of Image Sharpening On Radiographic Image Quality, Jefferson Lee Clark
Effect Of Image Sharpening On Radiographic Image Quality, Jefferson Lee Clark
Loma Linda University Electronic Theses, Dissertations & Projects
There is evidence that capture and processing of the digital radiographic images may contain artifacts that could reduce the diagnostic value of dental radiographs. This phenomenon has been reported through various case reports. However, its effect on radiographic image quality has not been studied. The purpose of this study is to evaluate the effect of image processing on the quality of dental digital radiographs using the most common type of filter; sharpening. Four imaging modalities (2 CMOS, 1 PSP, 1 conventional film) were used to radiograph a DDQA imaging phantom (Digital Dental Quality Assurance phantom) and to create a flat …
Clinicians’ Perspectives On Adopting A Lung Cancer Palliative Care Intervention, Shaunna Siler
Clinicians’ Perspectives On Adopting A Lung Cancer Palliative Care Intervention, Shaunna Siler
Loma Linda University Electronic Theses, Dissertations & Projects
Despite the significant progress in implementing palliative care interventions for cancer patients, few intervention studies seek healthcare clinicians’ input prior to implementation. The purpose of this research was then to explore palliative care and oncology clinicians’ (e.g., physicians, nurses, social workers, and chaplains) perspectives on current challenges and useful practices in meeting the quality of life needs of lung cancer patients and family caregivers, and to increase the likelihood of the adoption of a palliative care intervention based on understanding current trends in palliative care delivery at three outpatient oncology sites. The conceptual framework used for this study was the …
Coping As A Mediator Between Symptom Burden And Distress In Lung Cancer Patients, Spring F. Gehring
Coping As A Mediator Between Symptom Burden And Distress In Lung Cancer Patients, Spring F. Gehring
Loma Linda University Electronic Theses, Dissertations & Projects
Lung cancer is considered the leading cause of cancer death worldwide. An estimated 224,390 new cases of lung cancer are expected to be diagnosed and 158,080 Americans are expected to die from lung cancer in 2016 (National Institutes of Health, 2016; Siegel, Miller, & Jemal, 2016). Lung cancer patients also report the highest levels of psychological distress and symptom burden than any other forms of cancer (Linden, Vodermaier, MacKenzie, & Greig, 2012). Given the prevalence and impact of lung cancer, it is imperative to address the emotional toll this diagnosis can have on those suffering with the disease to develop …
Bonding And Psychosocial Adjustment Of Youth In Foster Care, Alicia Marie Nicoleau
Bonding And Psychosocial Adjustment Of Youth In Foster Care, Alicia Marie Nicoleau
Loma Linda University Electronic Theses, Dissertations & Projects
Foster families face complex issues that include a history of maltreatment, family disruption, placement instability, behavioral problems, and other adjustment related concerns. Adjusting to these issues presents unique challenges to foster youths and their families. Using family systems theory as the theoretical lens, this study explored the ways in which youth psychosocial adjustment is related to the interactions between foster parents and foster youth in long-term placement as perceived and reported by foster parents. This study utilized a qualitative methodology with a grounded theory approach. Using in-depth interviews, foster parents described their perceptions of how their foster youth cope and …
The Role Of Tgf-Β In Ctb-Insulin Regulated Human Dendritic Cell Tolerance, Grace Edosewe Esebanmen
The Role Of Tgf-Β In Ctb-Insulin Regulated Human Dendritic Cell Tolerance, Grace Edosewe Esebanmen
Loma Linda University Electronic Theses, Dissertations & Projects
Cholera toxin B subunit fusion to autoantigen vaccines such as proinsulin (CTB-INS) down regulates dendritic cell (DC) activation and induces the synthesis of DC immunosuppressive cytokines. Recent studies of CTB-INS induction of immune tolerance in human DCs indicate that increased IDO1 biosynthesis may play an important role in CTB-INS vaccine inhibition of DC activation. Previous studies suggest transforming growth factor beta (TGF-β) may play a role in the stimulation of IDO1 biosynthesis for induction of immunological tolerance in murine DCs. To elucidate the mechanisms by which CTB-INS may stimulate IDO1 biosynthesis and mediate tolerance in human DCs, we investigated the …