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- Alganite bite registration; Tooth length measurements; Dental Materials (1)
- Asymmetric reactions; Assymetric bonds; Organocatalysts (1)
- Back Support Angle; Body Posture Angles; Sagittal Head Angle; Cervical Angle; Shoulder Angle (1)
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- Grounded theory method; Nursing experiences; Infectious diseases (1)
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- High-risk Families; Social Cognitive Theory; Tele-coaching; Self-efficacy; Nurturing Parenting Program (1)
- Histomorphometric Analysis; Bone Formation; Maxillary Sinus Grafts; Bone Quality (1)
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- Immunological Homeostasis; Chimeric Fusion Protein Vaccine; Vaccine inhibitation; (1)
- Lingual Arch Activation; Transpalatal Arch Activation; Shape-Driven Method; Force-Driven Method (1)
- Microwave irradiation; Dentures; Dimensional stability; (1)
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- Neonatal hypoxic ischemic encephalopathy; Interferon Beta; Apoptosis; Brain Infarction; Encephalopathy (1)
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- Pelvic Floor Muscles; Pelvic Organ Prolapse; Intravaginal Pressure Transducer; Heavy Lifting (1)
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- Pomegranates; Polyphenols; Ischemic Stroke; Dietary Polyphenol Intake; Neuropsychological Effects (1)
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- Ricketts Analysis Measurements; Sirona Orthophos XG Plus; Dolphin (TM); Lateral cephalograms; (1)
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Articles 1 - 30 of 38
Full-Text Articles in Medicine and Health Sciences
Anti-Tumor Mechanisms Of Hpv16 E6*, Whitney S. Evans
Anti-Tumor Mechanisms Of Hpv16 E6*, Whitney S. Evans
Loma Linda University Electronic Theses, Dissertations & Projects
High-risk types of the human papillomavirus (HR-HPV) are the causative agents of nearly all cases of cervical cancer, as well as a significant number of head, neck, penile, vulvar and anal cancers. Like many other viruses with small genomes, HPV (~8 kb) utilizes numerous mechanisms to increase the capacity of its genome to encode the proteins necessary for successful completion of its infectious life cycle, including alternative splicing. Studies over the past few decades have focused intensively on the activities and roles of E6 proteins from HR-HPVs during the process of cellular transformation, clearly implicating E6 as a major transforming …
Effect Of Heavy Lifting With A Head Strap On The Pelvic Floor Across The Menstrual Cycle, Yvonne Biswokarma
Effect Of Heavy Lifting With A Head Strap On The Pelvic Floor Across The Menstrual Cycle, Yvonne Biswokarma
Loma Linda University Electronic Theses, Dissertations & Projects
Background: Pelvic organ prolapse (POP) occurs in 10% of women in Nepal, even 6% of nulliparous women have symptomatic POP.1 This may be linked to the heavy lifting tasks performed by women using a head strap.2 This study explored the impact of hormonal changes on the pelvic floor when performing these tasks during each phase of the menstrual cycle. Methods: The study included 22 female Nepali participants with a mean age of 27.4(3.6) years; all were from rural villages and frequently carried with a head strap. Using intravaginal pressure transducers (IVT), the mean change in intraabdominal pressure (IAP) was found …
Neuroprotective Molecules And Strategies In A Rat Model Of Neonatal Hypoxic Ischemic Encephalopathy, Brandon Joseph Dixon
Neuroprotective Molecules And Strategies In A Rat Model Of Neonatal Hypoxic Ischemic Encephalopathy, Brandon Joseph Dixon
Loma Linda University Electronic Theses, Dissertations & Projects
Neonatal hypoxic ischemic encephalopathy (HIE) is a devastating disease that primarily causes neuronal and white matter injury and is among the leading cause of death among infants. Currently there are no well-established treatments; thus, it is important to understand the pathophysiology of the disease and elucidate complications that are creating a gap between basic science and clinical translation. In the development of neuroprotective strategies and translation of experimental results in HIE, there are many limitations and challenges to master based on an appropriate study design, drug delivery properties, dosage, and use in neonates. Since there are no established therapies for …
Accuracy Of Implants Placed With Surgical Guides: Thermoplastic Vs. 3-D Printed, Caitlyn K. Bell
Accuracy Of Implants Placed With Surgical Guides: Thermoplastic Vs. 3-D Printed, Caitlyn K. Bell
Loma Linda University Electronic Theses, Dissertations & Projects
Purpose: The purpose of this study was to evaluate the accuracy of placed implants using two different guided implant surgery materials: thermoplastic vs. 3-D printed surgical guides. Materials and Methods:Twenty duplicate mandibular models, ten thermoplastic and ten 3-D printed surgical guides were used. Twenty implants were placed following the guided surgery protocol. Cone beam computed tomography scans of placed implants and the control implant were superimposed to measure deviations. Results: The thermoplastic group showed average deviations of 3.4 degrees, 1.3mm at the head, and 1.6mm at the apex of the implant compared to 2.36 degrees, 0.51mm, and …
Neuropsychological Effects Of Pomegranate Supplementation Following Ischemic Stroke, John A. Bellone
Neuropsychological Effects Of Pomegranate Supplementation Following Ischemic Stroke, John A. Bellone
Loma Linda University Electronic Theses, Dissertations & Projects
Polyphenols are compounds found in fruits and vegetables that have antioxidant and anti-inflammatory properties. Mounting evidence suggests that dietary polyphenol intake can reduce the detrimental effects of various disease processes, and pomegranates have frequently been examined because of their particularly high polyphenol content. Since stroke induces both oxidative stress and inflammation and is currently the leading cause of long-term disability in the U.S., we sought to determine whether dietary supplementation with polyphenols could enhance cognitive recovery in individuals who had suffered an ischemic stroke. We administered polyphenols via 2 POMx pills containing polyphenols derived from pomegranates equivalent to the content …
The Effect Of Orthodontic Treatment On Sagittal Root Position Of The Maxillary Central Incisor, Jeremy Haines
The Effect Of Orthodontic Treatment On Sagittal Root Position Of The Maxillary Central Incisor, Jeremy Haines
Loma Linda University Electronic Theses, Dissertations & Projects
Introduction: Sagittal root position (SRP) of maxillary incisors is an important factor in implant treatment planning. Kan et al defined four classes of SRP in an effort to aid implant placement treatment planning and these SRP classifications represent a novel approach to describing bone changes around the maxillary incisors. The effect of orthodontic tooth movement, specifically changes in inclination, on SRP is of interest in potentially facilitating immediate implant placement. Purpose: The purpose of this study was to use Cone Beam Computed Tomography (CBCT) to evaluate the adaptation of alveolar bone around the maxillary incisors as a result of orthodontic …
A Cbct Study Of Pharyngeal Airway Changes Due To Fixed Functional Appliances, Scott T. Peterson
A Cbct Study Of Pharyngeal Airway Changes Due To Fixed Functional Appliances, Scott T. Peterson
Loma Linda University Electronic Theses, Dissertations & Projects
Introduction: The purpose of this retrospective study, using head and neck Cone-Beam Computed Tomography (CBCT) images, was to measure and compare volumetric, area, and linear changes of the pharyngeal airway space in patients treated with a MARA or Herbst Class II correction appliances. Materials and Methods: Twenty-six patients treated with a MARA (mean age 13.2), nine with a Herbst (mean age 12.12) , and a control group twenty-five orthodontically treated class I patients (mean age 13.11). T1 and T2 CBCT images were measured and compared between the three groups for area, length, and width measurements along the velo-, oro-, and …
Ricketts Analysis Using Conventional And Dolphintm Generated Cbct Lateral Cephs, Yeganeh Parhizkar Jewell
Ricketts Analysis Using Conventional And Dolphintm Generated Cbct Lateral Cephs, Yeganeh Parhizkar Jewell
Loma Linda University Electronic Theses, Dissertations & Projects
Purpose: The aim of this study was to evaluate the difference between Ricketts analysis measurements made on Sirona Orthophos XG Plus (Sirona Dental Systems, Charlotte,NC) lateral cephalograms, and DolphinTM generated perspective and orthogonal lateral cephalograms from CBCT (NewTom 5G; QR srl, Verona, Italy). Materials and Methods: A Sirona digital lateral cephalogram and DophinTM synthesized CBCT lateral cephalograms of a radiographic phantom in orthogonal and perspective projections were created. Horizontal and vertical measurements were made in multiple planes on the radiographic phantom to compare each imaging modality. Twenty-five lateral cephalometric radiographs were selected retrospectively from the records of patients of …
Synthesis Of Huacat® Analogues As Novel Organocatalysts For The Formation Of Asymmetric C-C Bonds, Kenneth Laboy
Synthesis Of Huacat® Analogues As Novel Organocatalysts For The Formation Of Asymmetric C-C Bonds, Kenneth Laboy
Loma Linda University Electronic Theses, Dissertations & Projects
The synthesis of organic compounds with preferential stereochemistry is ubiquitous in the scientific community. A chemical reaction that asymmetrically induces one stereoisomer over another is achieved through the use of catalysts and various coupling reagents.1 Inorganic catalysts, such as TiCl4 and ZnCl2, have been documented for many decades as effective agents in the synthesis of asymmetric bonds, however, there are environmental limitations to their use. First, the asymmetric reactions involving these metal catalysts require solvents that are not environmentally-friendly, especially when used on an industrial scale and second, the metal catalysts are recycled when possible, however, there is always metal …
Relational Engagement And Empowerment: Establishing A Foundation To Address Gender And Power, Sarah K. Samman
Relational Engagement And Empowerment: Establishing A Foundation To Address Gender And Power, Sarah K. Samman
Loma Linda University Electronic Theses, Dissertations & Projects
Feminist informed therapists view relational distress as a complex reflection of the influences of larger disempowering discourses resulting in gendered power inequalities in heterosexual couple relationships. These disempowering discourses often manifest in males’ socialization to maintain autonomy compared to females’ socialization to orient toward the needs of others (Silverstein, Bass, Tuttle, Knudson-Martin, & Huenergardt, 2006). The general purpose of this study was to bridge the gap between feminist informed theory and practice using the Socio-Emotional Relationship Therapy (SERT; Knudson-Martin & Huenergardt, 2010) Model to relieve relational distress in heterosexual intimate partners often caused by these competing discourses toward a relational …
A Tele-Coaching Intervention To Support Families In The Npp+: An Experimental Mixed Method Design, Wendella Wray
A Tele-Coaching Intervention To Support Families In The Npp+: An Experimental Mixed Method Design, Wendella Wray
Loma Linda University Electronic Theses, Dissertations & Projects
Poverty is the single greatest threat to a child’s well-being. Poverty has been shown to exacerbate child maltreatment (CM) and minimize nurturing parenting. CM is a leading cause of death among children under the age of five in the United States. Both poverty and CM are major public health concerns worldwide with important implications for the family. For over three decades great focus has been placed on developing evidence-based (EB) parenting and family interventions to promote the well-being of high-risk families. Using a conceptual framework guided by elements of the social cognitive theory, attachment theory and family systems theory, this …
Comparison Of Two Methods Of Transpalatal Arch And Lingual Arch Activation, Taoran Zhang
Comparison Of Two Methods Of Transpalatal Arch And Lingual Arch Activation, Taoran Zhang
Loma Linda University Electronic Theses, Dissertations & Projects
The TPA and LA can be activated with two methods: the “shape-driven method” where the appliance is made to match the final tooth position and the “force-driven method” where the appliance is made to make sure the force system delivered by it at the beginning is consistent with the planned tooth movement. This study compared the two methods in vitro quantitatively with typodont teeth and multi-axis force torque transducers in all three dimensions. Results: In the TPA first order activation, with comparable Fy (force on Y axis) reading, the shape-driven activation group had a significantly higher Mx (moment on X …
An Evaluation Of Root Length Change Measurements Using Intraoral Scan And Panoramic Radiographs, Elijah C. Wang
An Evaluation Of Root Length Change Measurements Using Intraoral Scan And Panoramic Radiographs, Elijah C. Wang
Loma Linda University Electronic Theses, Dissertations & Projects
Introduction: This study was intended to evaluate the accuracy of using panoramic radiographs to measure root length change over the course of orthodontic treatment, using intraoral scans of crowns, and a mathematical model to account for distortions in the radiographs. The study additionally evaluated whether a best-fit equation could be created from the calculated data to minimize differences to the measurements of root resorption made on CBCT scans. Materials and Methods: Twenty-one patients were selected who had comprehensive orthodontic treatment, and all teeth in the upper right quadrant were evaluated in this study. T1 and T2 CBCT images were compared …
Correlation Of Tooth Length Measurements Made On Cbct And 3t Mr Images, Andrew Scott Taylor
Correlation Of Tooth Length Measurements Made On Cbct And 3t Mr Images, Andrew Scott Taylor
Loma Linda University Electronic Theses, Dissertations & Projects
Objective. This study compared tooth length measurements made on cone beam computed tomography (CBCT) scans and 3-Tesla (3T) magnetic resonance (MR) scans performed with and without an alginate bite registration surrounding the crowns of the teeth. Materials and Methods. One CBCT scan, one MR scan with alginate bite registration, and one MR scan without bite registration were performed on 12 subjects. The alginate bite registration was used to provide a proton-rich material to surround proton-poor teeth in an attempt to improve visualization of teeth. DICOM formatted images from each of the three scans for each subject were oriented in all …
Histomorphometric Analysis Of Maxillary Sinus Grafts: A Randomized Controlled Study, Mina Nishimoto
Histomorphometric Analysis Of Maxillary Sinus Grafts: A Randomized Controlled Study, Mina Nishimoto
Loma Linda University Electronic Theses, Dissertations & Projects
The purpose of this clinical investigation was to evaluate and compare the degree of new bone formation through histomorphometric analysis following maxillary sinus grafts (MSG) using three different bone graft materials. Thirty-one MSG were performed using a lateral window approach for patients who required implant placement in posterior maxilla. Each sinus was randomly selected to receive one of three bone graft materials; Group A: anorganic bovine bone mineral (ABBM) [Bio-Oss®], Group B: anorganic equine bone mineral (AEBM) [Equimatrix®], or Group C: mineralized cancellous bone allograft (MCBA) [OSSIF-i sem™]. A total of 28 bone cores were obtained at a mean time …
Effect Of Progressive Gaze Stability Exercises On Holistic Aspects Of Chronic Motion Sensitivity, Shilpa B. Gaikwad
Effect Of Progressive Gaze Stability Exercises On Holistic Aspects Of Chronic Motion Sensitivity, Shilpa B. Gaikwad
Loma Linda University Electronic Theses, Dissertations & Projects
Background: Motion sensitivity, also referred to as motion sickness, is a common condition among general population. It is a complex syndrome and is associated with presence of nausea and vomiting headache, drowsiness, cold sweating, pallor of varying degrees, increased salivation. Postural instability and anxiety are also identified to be associated with motion sensitivity. There is a close relationship between the vestibular system and motion sensitivity and vestibular system. The aim of this study was to investigate the effect of progressive gaze stability exercises on holistic aspects of chronic motion sensitivity. Methods: A single blind randomized controlled trial was conducted where …
Clinical Assessment Of Pragmatics (Caps): A Validation Study, Adriana Lavi
Clinical Assessment Of Pragmatics (Caps): A Validation Study, Adriana Lavi
Loma Linda University Electronic Theses, Dissertations & Projects
The purpose of this study was bi-fold: to develop and analyze the validity and reliability of a comprehensive pragmatic language diagnostic tool, the Clinical Assessment of Pragmatics as well as comparatively examine and analyze pragmatic language profiles of three groups of adolescents. These included students with Language Impairment (LI), High-Functioning Autism (HFA) and typically developing students. During the validation phase of the study, thirty participants, ages 14 to 16 years old, were administered 3 pragmatic judgment and 3 pragmatic performance subtests comprised of 10 items each for a total of 60 test items. A series of validity and reliability measures …
Effects Of Adjustments To Wheelchair Seat To Back Support Angle On Head, Neck, And Shoulder Postures, Afnan M. Alkhateeb
Effects Of Adjustments To Wheelchair Seat To Back Support Angle On Head, Neck, And Shoulder Postures, Afnan M. Alkhateeb
Loma Linda University Electronic Theses, Dissertations & Projects
Background: People spend a long time in the sitting position may have poor alignment that leads to neck and back pain. A wheelchair represents mobility for people with cerebral palsy, who are unable to walk. They spend long periods of time sitting in their wheelchair. Opining the seat to back support angle of the wheelchair enable realignment body segments and improves posture. Objective: 1) assessed the validity/reliability of Coach’s Eye (CE) smart device application, 2) examined the effect of seat to back support angle adjustments on head, neck, and shoulder posture in the sitting position, and 3) compared changes in …
Mechanisms Of Post-Hemorrhagic Hydrocephalus After Germinal Matrix Hemorrhage, Damon William Klebe
Mechanisms Of Post-Hemorrhagic Hydrocephalus After Germinal Matrix Hemorrhage, Damon William Klebe
Loma Linda University Electronic Theses, Dissertations & Projects
The inherently fragile vasculature of the germinal matrix is susceptible to rupture, possibly as a result of hemodynamic and cardiorespiratory instability associated with prematurity. Germinal matrix hemorrhage is a leading cause of morbidity and mortality in preterm and/or very low birthweight infants, and post-hemorrhagic hydrocephalus is major consequence of severe grade hemorrhages. Chronic post-hemorrhagic hydrocephalus treatment involves surgical insertion of shunts, which are costly and prone to complications. Thus, a safe non-invasive therapeutic approach towards post-hemorrhagic hydrocephalus clinical management would significantly improve the quality of life for this patient population. Thrombin, cerebroventricular blood clots, and iron have been identified as …
Proteomic Profiling Of Serum Derived Exosomes From Prostate Cancer Patients, David Turay
Proteomic Profiling Of Serum Derived Exosomes From Prostate Cancer Patients, David Turay
Loma Linda University Electronic Theses, Dissertations & Projects
Touted among the major achievements in the diagnosis and management of Prostate cancer (PCa) in the past few decades has been, the dramatic decline of men with advanced/metastatic PCa at diagnosis coupled with a significant improvement ( >90%) in the five and ten year survival rates of the disease. Non-palpable PCa (potentially clinically treatable disease) now accounts for 70-80% of all newly diagnosed cases of PCa. Preceding these changes by about a decade was the introduction of Prostatic Specific Antigen (PSA) into clinical practice; first as biomarker for monitoring response to therapy and subsequently as a complementary screening tool. It …
Oral Health Education Intervention To Assess Oral Health Knowledge And Behavioral Change, Ryan Bakhshi Baker
Oral Health Education Intervention To Assess Oral Health Knowledge And Behavioral Change, Ryan Bakhshi Baker
Loma Linda University Electronic Theses, Dissertations & Projects
The purpose of this study was to evaluate an oral health education intervention on oral health behaviors, oral health knowledge, and diet/amount of sugar consumed by fifth and sixth graders attending charter schools in the city of San Bernardino. Caries status of this particular population was recorded via dmft/DMFT and ICDAS. 143 students (aged 9-13 years) completed a 19 question pre-intervention survey related to oral health behaviors, dental knowledge and diet/amount of sugar consumed. Subjects then participated in an oral health education intervention comprised of an oral health education video and an interactive oral health game. An oral exam recorded …
Intimate Partner Violence In A Conservative Christian Denomination: Prevalence And Risk Factors, Carolyn Sallion-Love
Intimate Partner Violence In A Conservative Christian Denomination: Prevalence And Risk Factors, Carolyn Sallion-Love
Loma Linda University Electronic Theses, Dissertations & Projects
This study examines the prevalence and risk factors of intimate partner violence (IPV) in a Christian denomination. To date, no studies have been found in the literature that looked at IPV in a Christian denomination in South America, Latin America, and the Caribbean. Little is known regarding how church members from these countries experience victimization from IPV. One 2002 Inter-American Division (IAD) data set provides some insight into IPV; and the Seventh-day Adventist (SDA) Church has analyzed cross-sectional data of more than 7,000 SDA respondents from the study area of interest. Discriminant function analysis (DFA) was used to determine if …
The Role Of Collagen Interacting Proteins In The Pathogenesis Of Filifactor Alocis, Ozioma Salomey Chioma
The Role Of Collagen Interacting Proteins In The Pathogenesis Of Filifactor Alocis, Ozioma Salomey Chioma
Loma Linda University Electronic Theses, Dissertations & Projects
Filifactor alocis is a Gram-positive, asaccharolytic; obligate anaerobe that has emerged as a potential periodontal pathogen due to its presence in high numbers in patients who have periodontal disease and least detection in healthy individuals (Kumar et al., 2003, Kumar et al., 2006, Wade, 2011). There is compelling evidence in the literature that demonstrates that F. alocis has virulence properties that may play an important role in infection-induced periodontitis (Abusleme et al., 2013, Griffen et al., 2012, Hutter et al., 2003, Khader et al., 2006, Siqueira and Rocas, 2003, Siqueira et al., 2009). However, there is a gap in our …
Use Of Outcome-Present State Test Model Of Clinical Reasoning With Filipino Nursing Students, Susy Agustino Jael
Use Of Outcome-Present State Test Model Of Clinical Reasoning With Filipino Nursing Students, Susy Agustino Jael
Loma Linda University Electronic Theses, Dissertations & Projects
Clinical reasoning is a nursing competency necessary to make the best decision to deliver safe and effective care. A review of the literature shows a link between hazardous errors in patient care and poor clinical reasoning among nurses, and suggests that more study be given to best way to teach clinical reasoning. It is crucial that nurses today and of the future possess the clinical reasoning skills to provide increasingly complex patient care. This study tested the effect of the Outcome-Present State Test (OPT) Model of Clinical Reasoning on Filipino junior nursing students’ clinical reasoning scores on the Health Sciences …
Developmental Pedagogy In Marriage And Family Therapy Education, Christopher Russell Hoff
Developmental Pedagogy In Marriage And Family Therapy Education, Christopher Russell Hoff
Loma Linda University Electronic Theses, Dissertations & Projects
New practice domains are opening up for practitioners of family therapy in the medical, organizational, and human relations fields. In this new environment, family therapy educators and supervisors are required to cross the epistemological spaces of scientist-practitioner, postmodernism, and critical theory. These new possibilities require that family therapist educators become comfortable moving between multiple epistemologies. This poses increasing challenges that will require a hybridization of knowledge and practice approaches in MFT education. Through focus groups consisting of 34 participants, all of who were in their first quarter of a Master’s degree program in Marriage and Family Therapy. We found a …
Accuracy Of Volumetric Analysis Software Packages In Assessment Of Tooth Volume Using Cbct, Saylee Nimbalkar
Accuracy Of Volumetric Analysis Software Packages In Assessment Of Tooth Volume Using Cbct, Saylee Nimbalkar
Loma Linda University Electronic Theses, Dissertations & Projects
The purpose of this study was to evaluate the accuracy of volumetric analysis software packages in assessment of tooth volume using cone beam computed tomography and compare them to the volume obtained using an optical digital scanner. Twenty-four single rooted teeth indicated for extraction were collected. Cone beam computed tomography scans of these teeth resting in a custom scan jig were taken. Three dimensional digital models were obtained from the DICOM image cone beam computed tomography files using segmentation software packages (Anatomage, Mimics, and Amira) and volumes were calculated for each of the segmented teeth. The teeth were then scanned …
Exploring Factors In The Relationship Balance Assessment, Thomas B. Luttrell
Exploring Factors In The Relationship Balance Assessment, Thomas B. Luttrell
Loma Linda University Electronic Theses, Dissertations & Projects
While studies have highlighted the role of gendered power in relationships, many assumptions have not been quantitatively tested due to a lack of measures for power. This study uses exploratory factor analysis to construct a dyadic assessment of relative power and equality in relationships. This assessment would be useful for research and for clinical work with couples to help raise awareness of the balance of power in their relationship. Equality is defined as a mutual process in which both partners demonstrate that they hold equal value in the relationship, whereas inequality is when there is a relative imbalance of value …
Influence Of Low Temperature Degradation On Microstructural Integrity Of Zirconia Dental Implants, Mona Monzavi Rahimi
Influence Of Low Temperature Degradation On Microstructural Integrity Of Zirconia Dental Implants, Mona Monzavi Rahimi
Loma Linda University Electronic Theses, Dissertations & Projects
Zirconia dental implants have become more popular in the field of implant dentistry. However, concerns have been raised regarding low temperature degradation and its influence on phase stability and micro-structural integrity in terms of increased micro-crack formation. In the case of dental implants, this could possibly result in delamination and interference with bone to implant contact and eventually lead to loss of integration and failure. Nevertheless, no study has reported the effects on commercially available Zirconia dental implants. The primary aims of this study was to determine if there is a correlation between ageing duration and 1) depth of tetragonal-monoclinic …
Role Of Protein Kinase G In Regulating Vascular Tone In Hypoxic Ovine Cerebral Arteries, Richard Burdette Thorpe
Role Of Protein Kinase G In Regulating Vascular Tone In Hypoxic Ovine Cerebral Arteries, Richard Burdette Thorpe
Loma Linda University Electronic Theses, Dissertations & Projects
Nitric oxide (NO) and its precursors have been used clinically to induce vasorelaxation long before the specific mechanism of how this operates was understood. With the discovery in 1977 of the influence of NO on guanylate cyclase, and the subsequent elucidation of the NO pathway, the role of cyclic guanidine monophosphate (cGMP)-dependent protein kinase (PKG) has been shown to be the main mediator of NO-induced vasorelaxation. Less well understood is the behavior of this pathway in conditions of long term hypoxia (LTH). It was later shown that LTH attenuates the ability of PKG to mediate vasorelaxation. How this operates is …
Mechanism Of Chimeric Vaccine Mediated Immune Suppression Of Human Dendritic Cells, Jacques Christian Mbongue
Mechanism Of Chimeric Vaccine Mediated Immune Suppression Of Human Dendritic Cells, Jacques Christian Mbongue
Loma Linda University Electronic Theses, Dissertations & Projects
Type 1 diabetes mellitus is a chronic inflammatory disease in which insulin producing β-cells of the pancreatic islets are killed by autoreactive cells of the immune system in response to a loss of tolerance. Dendritic cells (DC) interact predominantly with naïve T cells to regulate the delicate balance between immunity and tolerance required to maintain immunological homeostasis. In this dissertation, immature human dendritic cells (iDC) were inoculated with a chimeric fusion protein vaccine containing the pancreatic β-cell auto-antigen proinsulin linked to a mucosal adjuvant the cholera toxin B subunit (CTB-INS). Proteomic analysis of vaccine inoculated DCs revealed strong up-regulation of …