Medicine and Health Sciences Commons^™

Word-Finding Difficulties: Exploring Tip-Of-The-Tongue States In Young And Old Adults, Allison J. Partridge

Electronic Thesis and Dissertation Repository

A Tip-of-the-Tongue (TOT) occurs when you are trying to think of a specific word but lack the ability to bring it to mind. The present study examined implicit learning processes operating under errorful (20-second delay) or errorless (0-second delay) learning conditions in TOT states. Participants included 15 young (20-30 years) and 15 old (65-88 years) adults who were tested twice a week for four weeks on a definition-word pair task. For young participants, results indicated that a TOT was more likely and older participants were more likely to indicate they did not know the word on a consecutive session after …

Neural Correlates Of Audiovisual Speech Perception In Aphasia And Healthy Aging, Sarah H. Baum

Dissertations & Theses (Open Access)

Understanding speech in face-to-face conversation utilizes the integration of multiple pieces of information, most importantly the auditory vocal sounds and visual lip movements. Prior studies of the neural underpinnings of audiovisual integration in the brain have provided converging evidence to suggest that neurons within the left superior temporal sulcus (STS) provide a critical neural hub for the integration of auditory and visual information in speech. While most studies of audiovisual processing focus on neural mechanisms within healthy, young adults, we currently know very little about how changes to the brain can affect audiovisual integration in speech. To examine this further, …

Effects Of Aging And Spectral Shaping On The Sub-Cortical (Brainstem) Differentiation Of Contrastive Stop Consonants, Dania A. Rishiq

Theses and Dissertations (ETD)

Purpose: The objectives of this dissertation are to: (1) evaluate the influence of aging on the sub-cortical (brainstem) differentiation of voiced stop consonants (i.e. /b-d-g/); (2) determine whether potential aging deficits at the brainstem level influence behavioral identification of the /b-d-g/ stimuli, (3) investigate whether spectral shaping diminishes any aging impairments at the brainstem level; and (4) if so, whether minimizing these deficits improves the behavioral identification of the speech stimuli.

Subjects: Behavioral and electrophysiological responses were collected from 11 older adults (> 50 years old) with near-normal to normal hearing and were compared to those of 16 normal-hearing younger …

The Effects Of 6-Weeks Of Resistance Training On The Neuromuscular Fatigue Threshold In Older Adults, Nadia Emerson

Electronic Theses and Dissertations

Age-related deficits in muscle mass, strength, and function place an increased burden of work on existing skeletal muscle and may lead to early onset of neuromuscular fatigue (NMF) during activities of daily living. Resistance exercise (RE) is the proven method for improving neuromuscular function in healthy older adults. PURPOSE: To investigate the effects of 6 weeks of RE on the NMF threshold as well as strength and functional performance in older adults. METHODS: Twenty-four older adults were randomly assigned to 6 weeks of RE (EXE; n = 12; age 72 ± 6.3 y; BMI 28.4 kg/m2 ) or control (CONT; …

Changes In Sleep Architecture And Cognition With Age And Psychosocial Stress: A Study In Fischer 344 Rats, Heather M. Buechel

Theses and Dissertations--Pharmacology and Nutritional Sciences

Changes in both sleep architecture and cognition are common with age. Typically these changes have a negative connotation: sleep fragmentation, insomnia, and deep sleep loss as well as forgetfulness, lack of focus, and even dementia and Alzheimer’s disease. Research has shown that psychosocial stressors, such as isolation from family and friends or loss of a loved one can also have significant negative effects on sleep architecture and cognitive capabilities. This leaves the elderly in a particularly vulnerable situation: suffering from cognitive decline and sleep dysregulation already, and more likely to respond negatively to psychosocial stressors. Taking all of these factors …

Age-Related Changes To The Production Of Linguistic Prosody, Daniel Richard Barnes

Open Access Theses

The production of speech prosody (the rhythm, pausing, and intonation associated with natural speech) is critical to effective communication. The current study investigated the impact of age-related changes to physiology and cognition in relation to the production of two types of linguistic prosody: lexical stress and the disambiguation of syntactically ambiguous utterances. Analyses of the acoustic correlates of stress: speech intensity (or sound-pressure level; SPL), fundamental frequency (F0), key word/phrase duration, and pause duration revealed that both young and older adults effectively use these acoustic features to signal linguistic prosody, although the relative weighting of cues differed by group. Differences …

An Intergenerational Leisure Activity Program To Promote Successful Aging, Rachel Becker, Jason Zacharias

Occupational Therapy Capstones

PROBLEM: By the year 2030, older adults who are 65 years of age or older will account for 20% of the US population (Center for Disease Control, 2008); however, the rate of successful aging has decreased 25% from 1998 to 2004 (McLaughlin, Connell, Heeringa, Li, &Roberts, 2009).

PURPOSE: The purpose of this scholarly project is to develop an intergenerational program that will promote successful aging of older adults. METHOD: A literature review was conducted on older adults and successful aging using PubMed, OT search, CINAHL, AJOT, Google scholar, and textbooks. RESULTS: Researchers indicated that intergenerational programs promote successful aging and …

Getting To The Other Side: An Exploration Of The Head And Neck Cancer Treatment Experience, Heather M. Wallace

Theses and Dissertations--Gerontology

Diagnosis of head and neck squamous cell carcinoma (HNSCC) presents a multifarious problem. Late stage diagnosis, uncertainty regarding appropriate clinical treatment, as well as the high potential for disfigurement and functional loss resulting in diminished quality of life, contributes to anxiety, stress, fear, and uncertainty throughout the cancer treatment experience. This qualitative study sought to explore the cancer treatment experience of adults with newly diagnosed HNSCC, including laryngeal, esophageal, and oral cancers. Study participants were recruited from the University of Kentucky Ear Nose and Throat Clinic in Lexington KY. Participants agreed to be interviewed after receipt of their cancer diagnosis …

Memory, Cognition, And The Effect Of A Music Intervention On Healthy Older Adults, Shannon L. Bowles

Theses and Dissertations--Gerontology

Music is a powerful modality that can bring about changes in individuals of all ages. This research employed both an experimental and quasi-experimental design to identify the effects of music as it influenced psychological well-being, memory, and cognition among older adults. Specifically, it addressed three aims: (a) To determine to what extent learning to play a music instrument later in life influenced psychological well-being and cognitive function of non-institutionalized healthy seniors, (b) To determine the effects of the amount of music involvement on psychological well-being and cognitive function (c) To determine the benefit of music for those with limited/no music …

The Influence Of Gender And Aging On The Neural Circuitry Supporing Facial Emotion Processing In Adults With Major Depressive Disorder, Emily Briceno

Wayne State University Dissertations

Major Depressive Disorder (MDD) is associated with decrements in facial emotion processing (FEP). Previous studies investigating the neural substrates of these decrements have often reported hyperactivity of emotion processing circuitry. Neural circuitry supporting FEP has been shown to be different between healthy men and women, and between young and elder adults. However, no prior studies have investigated how gender and aging affect emotion processing circuitry in individuals with MDD. The present study aimed to investigate the influence of gender and aging on emotion processing circuitry in MDD. One hundred-ten adults, grouped into subgroups according to MDD status, gender, and age …

Effects Of Intranasally Administered Dnsp-11 On The Central Dopamine System Of Normal And Parkinsonian Fischer 344 Rats, James H. Sonne

Theses and Dissertations--Neuroscience

Due to the blood-brain barrier, delivery of many drugs to the brain has required intracranial surgery which is prone to complication. Here we show that Dopamine Neuron Stimulating Peptide 11 (DNSP-11), following non-invasive intranasal administration, protects dopaminergic neurons from a lesion model of Parkinson’s disease in the rat. A significant and dose-dependent increase in an index of dopamine turnover (the ratio of DOPAC to dopamine) was observed in the striatum of normal young adult Fischer 344 rats by whole-tissue neurochemistry compared to vehicle administered controls.

Among animals challenged with a moderate, unilateral 6-hydroxy-dopamine (6-OHDA) lesion of the substantia nigra, those …