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Full-Text Articles in Medicine and Health Sciences
Prevalence And Correlates Of Drug Abstinence Following Substance Abuse Treatment, Angela Cheryl Ni
Prevalence And Correlates Of Drug Abstinence Following Substance Abuse Treatment, Angela Cheryl Ni
Yale Medicine Thesis Digital Library
No abstract provided.
Positive And Negative Modulatory Roles Of Platelet Endothelial Cell Adhesion Molecule-1 Signaling In Endothelial Cell Migration: Coordination Of Rho Signaling And Targeting Of Shp-2 Tyrosine Phosphatase Activity, Dita Gratzinger
Yale Medicine Thesis Digital Library
Platelet Endothelial Cell Adhesion Molecule-1 (PECAM-1), an immunoglobulin family adhesion molecule, is involved in endothelial migration and angiogenesis. We found that PECAM-1 deficient endothelial cells exhibit enhanced nondirected single cell motility and extension formation at the expense of wound-healing migration. These in vitro endothelial behaviors model aspects of highly developmentally and pathophysiologically relevant processes. Wound healing migration may model the reendothelialization of denuded vasculature following balloon angioplasty or the remodeling of vascular endothelium under variant flow conditions, while single cell motility is prominently involved in developmental processes such as endocardial-mesenchymal transition within the cardiac cushion. A specific deficiency of RhoGTP …
Direct Evidence For A Membrane Deforming Motif In Endophilin: Implications Beyond Synaptic Vesicle Recycling, Khashayar Farsad
Direct Evidence For A Membrane Deforming Motif In Endophilin: Implications Beyond Synaptic Vesicle Recycling, Khashayar Farsad
Yale Medicine Thesis Digital Library
Effective neurotransmission is dependent on fast, reproduceable synaptic vesicle recycling. The synaptic vesicle recycling process is a complex event involving both protein-protein, as well as protein-lipid interactions. A central part of the retrieval process of synaptic vesicles lies in the ability of soluble proteins to deform the plasma membrane into a nascent bud which will eventually reform a fully competent synaptic vesicle upon fission. This process involves clathrin-coat proteins, which form a protein scaffold around the vesicle bud, as well as proteins which have more recently been thought to be involved in generating the high curvature membranes present at the …
In Utero Indomethacin Alters O₂ [Oxygen] Delivery To The Fetal Ductus Arteriosus : Implications For Persistent Postnatal Patency, Seth Hamlin Goldbarg
In Utero Indomethacin Alters O₂ [Oxygen] Delivery To The Fetal Ductus Arteriosus : Implications For Persistent Postnatal Patency, Seth Hamlin Goldbarg
Yale Medicine Thesis Digital Library
Exposure of the fetus to indomethacin produces constriction of the fetal ductus arteriosus (DA) and hypoxia in the avascular muscle media of the vessel wall. Hypoxia induces cell death, which increases the incidence of patent DA in the newborn period. We used a fetal sheep model to determine the factors that were responsible for indomethacin-induced hypoxia at various degrees of DA constriction. Indomethacin produced DA constriction in all fetuses studied in vivo. Cell death in the DA wall was directly related to the degree of indomethacin-induced DA constriction and was present at both moderate (pressure gradient across DA <16 >mmHg) and …
Developing Anti-Cd30 Recombinant Immunotoxins Targeting Shed And Non-Shed Epitopes For Cancer Therapy, Abhishek Sinha
Developing Anti-Cd30 Recombinant Immunotoxins Targeting Shed And Non-Shed Epitopes For Cancer Therapy, Abhishek Sinha
Yale Medicine Thesis Digital Library
No abstract provided.