Medicine and Health Sciences Commons^™

Malignant Hyperthermia, Jessica Joos

Nursing Student Class Projects (Formerly MSN)

Being a proficient anesthesia provider requires vigilantly monitoring for any complications that may arise during the anesthetic period. Malignant Hyperthermia (MH) is one such complication. Succinylcholine, a neuromuscular blocking agent, and volatile anesthetic gases can initiate an MH reaction. In MH, ryanodine receptors are stimulated to release excess calcium, which causes muscle hypermetabolism. This process causes the patient to develop highly elevated temperatures, hypoxia, hypercarbia, and muscle rigidity. Left untreated, MH can be fatal. Treatment requires discontinuation of the triggering agent, administering dantrolene, providing 100% oxygen, and managing complications such as acidosis, hyperkalemia, and arrhythmias. MH is a manageable complication …

Malignant Hyperthermia, Christina Bensley

Nursing Student Class Projects (Formerly MSN)

Malignant Hyperthermia

Christina Bensley

Department of Nursing, Otterbein University

NURS 6810: Advanced Pathophysiology for the Advanced Practice Nurse

Dr. Batross and Dr. Bhatnagar

August 5th, 2022

Abstract

Malignant Hyperthermia (MH) is a rare genetic mutation of the skeletal muscle that induces a hypermetabolic response when patients are exposed to volatile inhaled anesthetics or depolarizing neuromuscular blockers (Weant & Gregory, 2021). The first case of MH was identified in 1960, with an estimated mortality rate of 70-80% without appropriate treatment (Hopkins et al., 2021). Perioperative care providers must be able to identify triggering agents, recognize presenting signs and symptoms, and know …

Malignant Hyperthermia, Shannen Steinbrunner

Nursing Student Class Projects (Formerly MSN)

This poster aims to investigate the concept of malignant hyperthermia (MH). MH is a rare and fatal skeletal muscle reaction that can progress rapidly, especially if advanced practice nurses do not recognize the symptoms or know how to treat them (Hopkins et al., 2021). This hypermetabolic disorder has predisposing factors that should alert APRNs to avoid specific trigger agents such as volatile anesthetics and succinylcholine (Rosenbaum & Rosenburg, 2022). Genetic predispositions also play a significant role in the etiology of MH (Hopkins et al., 2021). Viewers will learn why dantrolene is the medication of choice for MH and why symptoms, …

Perioperative Malignant Hyperthermia, Mitchell Mccorkle

Nursing Student Class Projects (Formerly MSN)

Abstract

Malignant Hyperthermia (MH) is a rare inherited disorder in which exposure to triggering agents such as volatile anesthetics or depolarizing neuromuscular blockers causes a hypermetabolic reaction leading to patient fatality. MH susceptible patients have a genetic mutation on the ryanodine one receptor (RYR1) in skeletal muscle, allowing uninhibited calcium release (Smith, Tranovich, & Ebraheim, 2018). Increases in free calcium result in an uncontrollable sustained muscle contraction through the excitation-contraction coupling of myosin and actin. Sustained muscle contraction rapidly consumes adenosine triphosphate stores and stimulates conversion to lactate producing anaerobic metabolism (Smith et al., 2018). Immediate recognition and treatment of …

Malignant Hyperthermia, Joel Jackson

Nursing Student Class Projects (Formerly MSN)

Malignant hyperthermia (MH) is a hypermetabolic response to succinylcholine or inhaled volatile gases administered during anesthesia and is caused by an autosomal dominant mutation of RYR1 or CACNA1S genes which affect how calcium channels function. The uncontrolled, unopposed calcium release and excitation-contraction coupling results in sustained skeletal muscle contraction resulting in muscle rigidity, hyperthermia, hypercapnia, hypertension, and tachycardia among other less common clinical features. The sequelae of an MH crisis include renal failure, rhabdomyolysis, hyperkalemia, metabolic disturbance and left untreated will result in mortality. All clinicians involved in peri-operative care both in-hospital and out of hospital must be cognizant of …

Malignant Hyperthermia, Courtney Morris

Nursing Student Class Projects (Formerly MSN)

Malignant Hyperthermia as defined by the International Classification of Diseases is a rare but progressive, and life-threatening hyperthermic reaction in response to a triggering agent such as general anesthetic gases or the depolarizing neuromuscular blocking agent Succinylcholine (Hopkins et. al., 2020). MalignantHyperthymia is a genetic disorder of the skeletal muscle, that leads to continuous muscle contraction and the inability to relax skeletal muscle (Haili and Weant, 2021). Signs and symptoms can vary from patient to patient and can be masked by anesthesia, but the classical signs include an increase in end-tidal CO2, increased heart rate, and a rapid increase in …

Malignant Hyperthermia, Nicholas Colangelo

Nursing Student Class Projects (Formerly MSN)

Malignant hyperthermia is a rare manifestation of a genetic mutation involving the ryanodine receptors. This mutation causes a sustained intracellular calcium release that is triggered by certain anesthetics such as depolarizing neuromuscular blockers and volatile gases. The extended release of calcium functions as a dangerous catalyst for hyper-metabolism that will lead to rapid death if unrecognized and untreated. Current treatment involves the drug dantrolene in tandem with symptomatic management in the intensive care setting. Symptomatic treatment may likely involve rapid cooling, fluid resuscitation, electrolyte management, and mechanical ventilation until symptoms resolve. A literature review of malignant hyperthermia is of vital …

Malignant Hyperthermia, Alec Smith

Nursing Student Class Projects (Formerly MSN)

Abstract: There are many issues that healthcare professionals face in the evolving world of medicine. One of these is the development of a disease process known as Malignant Hyperthermia (MH). This condition is precipitated by frequently used anesthetic agents such as volatile gases and depolarizing muscle relaxants. The onset of MH is sudden and can be life-threatening, therefore, diligent monitoring of patients is essential in early recognition and treatment of MH. The purpose of this poster is to provide in -depth knowledge about MH. This includes the pathophysiology of the disease, signs and symptoms, treatment options, and implications MH has …

Malignant Hyperthermia, Courtney Stevenson

Nursing Student Class Projects (Formerly MSN)

Malignant Hyperthermia (MH) is a rare but life-threatening medical emergency. It is a skeletal muscle disorder that leads to a hypermetabolic reaction. It occurs in response to the administration of inhaled anesthetics and depolarizing muscle relaxants.

Malignant Hyperthermia, Alexandra Mcguire

Nursing Student Class Projects (Formerly MSN)

Malignant Hyperthermia (MH) is a rare but life-threatening, genetic condition that can manifest when a patient is exposed to certain inhalation agents used in anesthesia as well as the depolarizing muscle relaxant succinylcholine (Rosenberg, Pollock, Schiemann, Bulger, & Stowell, 2015, p. 1). MH can develop during or after a surgical procedure and if left untreated, can cause major organ system damage and death (Seifert, Wahr, Pace, Cochrane, & Bagnola, 2014, p. 189). Creating awareness of this rare genetic condition allows for quicker interventions in reversing MH.

Malignant Hyperthermia, Ashley Casimir Vasnaik

Nursing Student Class Projects (Formerly MSN)

The Certified Registered Nurse Anesthetist (CRNA), as well as other anesthesia providers and support staff interact with a variety of patients on a day to day basis. These patients come to the hospital to seek help for their medical and surgical ailments. As every patient is different, they can also have a variety of health-related issues, many of which can also impact their anesthetic plan. One of the most difficult issues and or emergent situations that can impact everyone in the operating room is an exacerbation of Malignant Hyperthermia (MH), whether it is anticipated or unanticipated. The task of preventing …

Malignant Hyperthermia, Brandon Kinnamon

Nursing Student Class Projects (Formerly MSN)

Common anesthetic agents can trigger a pathological response in patients resulting in intracellular calcium release and hyper-metabolism. This condition is known as Malignant Hyperthermia (MH). It is vital for anesthesia professionals and critical care nurses to recognize MH and act quickly to limit rapid shifts of electrolytes which can ultimately lead to death. As soon as cardinal signs of malignant hyperthermia are identified, the medication dantrolene should be administered along with intensive nursing care. Significant signs and symptoms, the pathophysiology of MH, and implications for nursing care are all examined in greater detail.

Malignant Hyperthermia, David Kanotz

Nursing Student Class Projects (Formerly MSN)

Malignant Hyperthermia (MH) is a life-threatening skeletal muscle disorder that presents as a hypermetabolic response to several inhaled anesthetics and to the depolarizing muscle relaxant succinylcholine. It is extremely important for certified registered nurse anesthetist (CRNA) to understand the pathophysiology, clinical symptoms, and treatment plan of MH due to their vital role in managing these patients in the operating room.

Malignant Hyperthermia, Daniel Talbot

Nursing Student Class Projects (Formerly MSN)

Malignant Hyperthermia overview, signs and symptoms, pathophysiology, treatment, and implications for nursing care.

Malignant Hyperthermia, Taylor M. Morriss

Nursing Student Class Projects (Formerly MSN)

Complications related to the anesthetic process are multifaceted and abundant. As a future nurse anesthesia student, the underlying pathophysiology, diagnosis, and treatment of anesthesia-related complications are of particular interest. One such anesthesia-induced life-threatening metabolic process involves the hypermetabolism of skeletal muscle. This pharmacogenetic process, known as malignant hyperthermia (MH), has a variable incidence rate ranging from 1:10,000 to 1: 250,000 anesthetic cases. However, the prevalence of the genetic abnormalities may be as great as one in 400 individuals (Rosenberg, Pollock, Schiemann, Bulger, & Stowell, 2015, p. 1). “Malignant hyperthermia (MH) is a rare, but life-threatening, autosomal-dominant inherited disorder that may …

Malignant Hyperthermia, Leonid Levertov

Nursing Student Class Projects (Formerly MSN)

Providing patient care in the operating room as a nurse anesthetist is rewarding and challenging. There is a paramount level of responsibility that lies on certified registered nurse anesthetist (CRNA). Recognition of serious life threatening conditions by CRNA must be prompt and treated urgently. As a student registered nurse anesthetist and future CRNA, knowing how to recognize and treat developed emergency conditions while patient is under anesthesia or recovering from anesthesia is an absolute requirement. Malignant hyperthermia (MH), is a rare autosomal dominant hypermetabolic life threatening disorder of skeletal muscle. Malignant hyperthermia is caused by volatile anesthetics (desflurane, sevoflurane, isoflurane) …