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Articles 1 - 30 of 94
Full-Text Articles in Medicine and Health Sciences
Insulin Signaling And Function In Osteoblasts, Keertik S. Fulzele
Insulin Signaling And Function In Osteoblasts, Keertik S. Fulzele
All ETDs from UAB
Insulin and insulin-like growth factor-1 (IGF-1) are evolutionarily conserved hormonal signaling pathways with structurally similar ligands and receptors. Recent stu-dies suggest that that insulin and IGF-1 exert distinct as well as overlapping functions to regulate different aspects of skeletal development. A major problem in distinguishing the actions of insulin and IGF-1 is the fact that the receptors are co-expressed in many cell types and each ligand is able to cross-activate the other ligands' receptor. To distinguish direct skeletal actions of insulin from that of IGF-1, we have conditionally disrupted each receptor in vitro and in vivo specifically in osteoblasts. Studies …
Mechanisms And Countermeasures Of Microgravity Induced Bone Loss: In Vitro And In Vivo Model Systems, Ritu Saxena
Mechanisms And Countermeasures Of Microgravity Induced Bone Loss: In Vitro And In Vivo Model Systems, Ritu Saxena
All ETDs from UAB
Rapid bone loss occurs during prolonged periods of weightlessness experienced by astronauts during spaceflights which leads to osteopenia and increased fracture risk upon return to earth. Spaceflight studies have shown that the bone loss occurs as a result of both a decrease in bone formation and an increase in bone resorption, however, the molecular mechanisms still need to be elucidated. Previous studies from our laboratory and other groups have indicated that modeled microgravity leads to inhibition of osteoblastogenesis and a stimulation of adipogenesis of human mesenchymal stem cells in osteogenic medium which is most likely mediated by a decrease in …
The Role Of Mitochondria And Plasma Membrane Ca2+ Transport Systems In Ca2+-Dependent Glutamate Release From Rat Cortical Astrocytes, Reno Cervo Reyes
The Role Of Mitochondria And Plasma Membrane Ca2+ Transport Systems In Ca2+-Dependent Glutamate Release From Rat Cortical Astrocytes, Reno Cervo Reyes
All ETDs from UAB
Astrocytes, a type of glial cell in the central nervous system, are recognized for their support roles to neurons. They supply neurons with metabolites, maintain ion homeostasis and clear the synaptic space of neurotransmitters. However, it has been found that some astrocytes have receptors for neurotransmitter and neuroligands, exhibit Ca2+ excitability when stimulated via these receptors, and secrete gliotransmitters as an output of this Ca2+ excitability. In the Ca2+-dependent release of glutamate, it has been shown that the endoplasmic reticulum is the predominant source and the extracellular space is the auxiliary source of free Ca2+ necessary for triggering exocytosis. Because …
The Effect Of Zinc On Cytokine Release And Signal Transduction In Airway Epithelial Cells, Nai-Lin Cheng
The Effect Of Zinc On Cytokine Release And Signal Transduction In Airway Epithelial Cells, Nai-Lin Cheng
All ETDs from UAB
Zinc is an essential cation for life that is involved in numerous physiology and pathophysiology processes. Despite its wide use as a cytoprotective agent in medications, its cellular and molecular mechanisms of action have not been well established. In order to define the potential therapeutic benefit of zinc, I used several Cystic Fibrosis (CF) and non-CF human airway epithelial cell lines as models in my studies. Extracellular zinc caused release calcium from the endoplasmic reticulum though zinc-sensitive Gq-coupled receptor(s) that may subsequently modulate ion channels. In addition, zinc also exhibited anti-inflammatory effects. Zinc inhibited pro-inflammatory molecular TNFα-induced cytokine and chemokine …
Oncostatin M-Induced Gene Expression And Regulation In Astrocytes And Microglia, Brandi Janece Baker
Oncostatin M-Induced Gene Expression And Regulation In Astrocytes And Microglia, Brandi Janece Baker
All ETDs from UAB
Astrocytes and microglia are specialized glial cells of the Central Nervous System (CNS) that modulate neural activity and regulate immunological and inflammatory events. These cells perform their functions, in part, through the secretion of soluble mediators such as cytokines and chemokines. However, in response to the same neurological insult or inflammatory stimuli, the responses of these cells can vary greatly. This notion of differential responses was examined in our studies using Oncostatin M (OSM). OSM is a member of the IL-6 family of cytokines, which can be produced by microglia, astrocytes, neurons, and infiltrating leukocytes in the CNS, and is …
The Potential Role Of Vh Replacement In Editing And Generating Autoreactive Antibodies, Run Fan
The Potential Role Of Vh Replacement In Editing And Generating Autoreactive Antibodies, Run Fan
All ETDs from UAB
VH replacement occurs through RAG-mediated secondary recombination between an upstream VH gene and an existing VHDJH joint. In the first part of this dissertation, we focused on the potential regulation of VH replacement in the human B lineage EU12 cells muHC+ population, which underwent spontaneous VH replacement during in vitro culture. We cloned one of the dominant IgH genes, A19H, expressed in the EU12 muHC+ cells, and generated recombinant antibodies. We found that these recombinant antibodies recognize SM antigens. The anti-SM reactivity of A19H can not be efficiently neutralized by a randomly selected group of fourteen IgL chains from healthy …
Intracellular Trafficking Of The Hantaviral Nucleocapsid Protein And Its Function In Modulation Of Immune Signaling, Steven Joe Ontiveros
Intracellular Trafficking Of The Hantaviral Nucleocapsid Protein And Its Function In Modulation Of Immune Signaling, Steven Joe Ontiveros
All ETDs from UAB
Old World and New World hantaviruses, family Bunyaviridae, mature intracellularly within cellular compartments. Although it is generally accepted they assemble and bud in the Golgi apparatus the site remains controversial for New World hantaviruses, because some studies have raised the possibility of their maturation at the plasma membrane. Furthermore, the site of assembly hantaviruses still remains undetermined. The nucleocapsid (N) protein has been proposed to play a key role in facilitating assembly. To gain insight into the assembly pathways of Old World hantaviruses, we examine the intracellular trafficking of the Hantaan (HTN) virus N protein. We show progressive redistribution of …
Design Of The Predictive Power Method With Two Endpoints, Kiya R. Hamilton
Design Of The Predictive Power Method With Two Endpoints, Kiya R. Hamilton
All ETDs from UAB
Three reasons to review accumulating data in clinical trials include: ethical issues, financial concerns and administrative concerns. Interim analysis is a good way to monitor accumulating data in clinical trials. Interim analysis allows for the possibility that a study may be terminated early; that is, if the currently observed data convincingly favor the null or the alternative hypothesis then the study ends early. In addition, many clinical trials are conducted to compare a treatment group to a standard group on multiple endpoints. Combining interim analyses with multiple endpoints allows for more information to be provided from the trial than either …
The Effects Of Bisphenol A (Bpa) On Erbb2-Positive Breast Cancer, Sarah Jenkins
The Effects Of Bisphenol A (Bpa) On Erbb2-Positive Breast Cancer, Sarah Jenkins
All ETDs from UAB
Bisphenol A (BPA) is a synthetically made compound used to produce a myriad of consumer goods. Recent studies have shown BPA to leach from these products in appreciable amounts, resulting in nearly ubiquitous exposure. In this study, we assessed whether chronic administration to a range of low concentrations of BPA could accelerate spontaneously developing mammary cancer using a transgenic model that over-expresses wild type ErbB2/neu transgene (MMTV-erbB2). MMTV-erbB2 mice were provided drinking water containing 0 (control), 2.5 (BPA 2.5), 25 (BPA 25), 250 (BPA 250), or 2500 (BPA 2500) µg BPA/L from eight weeks of age until sacrifice. This range …
Development And Implementation Of Knock-In And Bac-In Il-2 Reporter Mouse Models To Characterize Il2 Gene Regulation In Cd4 T Cells, Rita Jeanne Luther
Development And Implementation Of Knock-In And Bac-In Il-2 Reporter Mouse Models To Characterize Il2 Gene Regulation In Cd4 T Cells, Rita Jeanne Luther
All ETDs from UAB
Maintenance of immune homeostasis involves a balance between T cell effector responses to antigen stimulus and reciprocal downregulation of this response through peripheral tolerance mechanisms. Upon exposure to pathogen, cytokine production and signaling serve to tightly coordinate cell-mediated clearance of antigen followed by contraction of the immune response. Interkeukin-2 (IL-2) is a type I family cytokine critical for expansion of activated T cells in vitro and enhancement of T cell memory responses in vivo. Deficiency of IL-2 in vivo also revealed a critical role for IL-2 in immune tolerance through the maintenance of T regulatory cell populations (Treg) in peripheral …
Localization And Function Of Electrogenic Na/Bicarbonate Cotransporter Nbce1 In Rat Brain, Debeshi Majumdar
Localization And Function Of Electrogenic Na/Bicarbonate Cotransporter Nbce1 In Rat Brain, Debeshi Majumdar
All ETDs from UAB
Na-Coupled Bicarbonate Transporters (NCBTs) are members of the bicarbonate transporter superfamily that play important roles in regulating intracellular pH (pHi) and extracellular pH (pHo) in the central nervous system. Electrogenic Na/bicarbonate Cotransporter 1 (NBCe1) is an NCBT that is expressed in different mammalian tissues including the brain. NBCe1 has three splice variants - NBCe1-A, -B and -C - that differ in the amino and carboxy termini. We have first performed a systematic characterization of the localization profiles of the three NBCe1 splice variants at mRNA and protein levels in rat brain. In these studies, we have used anti-sense probes and …
Characterizing The Role Of Primary Cilia In The Hair Follicle And Skin, Jonathan Merle Lehman
Characterizing The Role Of Primary Cilia In The Hair Follicle And Skin, Jonathan Merle Lehman
All ETDs from UAB
Primary cilia have been established as a nearly ubiquitous microtubule based signaling organelle, yet their function in many organs, including the hair and skin, is unknown. We hypothesized that the primary cilium would play vital roles in the hair follicle and skin based on the cilium's well characterized interactions with the Shh and Wnt developmental signaling pathways. This dissertation describes our efforts to determine the localization of the primary cilia in the murine hair follicle and assess the function of this organelle in the hair and skin. We used confocal immunofluorescence microscopy to virtually section the entire hair follicle and …
Regulation Of The Human Heme Oxygenase-1 Gene By Nitro-Linoleic Acid, Macienne M. Wright
Regulation Of The Human Heme Oxygenase-1 Gene By Nitro-Linoleic Acid, Macienne M. Wright
All ETDs from UAB
Nitro-fatty acids (NO-FA) exert anti-inflammatory effects in the vasculature. Heme oxygenase-1 (HO-1) degrades heme into iron, biliverdin, and carbon monoxide and is up-regulated as an adaptive and protective response to inflammatory processes. This dissertation examined whether nitro-linoleic acid (LNO2) induced HO-1 gene expression and evaluated the molecular mechanism of induction in human aortic endothelial (HAEC), human embryonic kidney 293 (HEK 293) and mouse embryonic fibroblast (MEF) cells. LNO2 induced HO-1 mRNA and protein in HAEC at the level of transcription. NO scavenging by carboxy-PTIO partially reversed LNO2–mediated induction of HO-1, suggesting that LNO2 acts via NO-dependent and NO-independent mechanisms of …
The Role Of The Ss2-Integrin Family On T Cell Subsets, Jillian E. Wohler
The Role Of The Ss2-Integrin Family On T Cell Subsets, Jillian E. Wohler
All ETDs from UAB
Members of the ß2-integrin family of adhesion molecules, CD11a, CD11b, and CD11c, have all been shown to play a role in the pathogenesis of experimental autoimmune encephalomyelitis (EAE). CD11d had yet to be studied in demyelinating disease and its functions remained unclear. We report here that CD11d is the only member of the ß2-integrin family of adhesion molecules that fails to protect against the development of EAE. Surprisingly, the EAE studies suggested that CD11a, CD11b, and CD11c were all contributing to T cell activity during disease development by mechanisms beyond the migration of these cells into the CNS. However, the …
Protein Trafficking And 4.1r Relocalization In Plamodium Falciparum-Infected Erythrocytes, Lindsay A. Parish
Protein Trafficking And 4.1r Relocalization In Plamodium Falciparum-Infected Erythrocytes, Lindsay A. Parish
All ETDs from UAB
Malaria is a mosquito-borne infectious disease that is caused by parasites in the genus Plasmodium. There are four species of malaria that routinely infect humans, but it is P. falciparum that is responsible for the majority of the severe and fatal cases of malaria. P. falciparum has a complex life cycle involving a mosquito vector and intracellular stages in both hepatocytes and erythrocytes; however, it is only the intraerythrocytic stages that are the cause of the pathology associated with malaria. This pathology is largely due to the ability of infected erythrocytes to cytoadhere to host microvasculature. After invasion, the parasite …
Comparisons Between Behavioral And Electrophysiological Measures Of Visual Function In Rodent Models Of Retinal Degeneration, Glen R. Rubin
Comparisons Between Behavioral And Electrophysiological Measures Of Visual Function In Rodent Models Of Retinal Degeneration, Glen R. Rubin
All ETDs from UAB
The critical flicker frequency (CFF) is the lowest frequency for which a flickering light appears steady. Measuring CFF indicates rod- and cone-driven function relative to light intensity. CFF can be measured by both electroretinogram (ERG) and behavior. We measured CFF in several rodent models of retinal degeneration in order to better characterize retinal degeneration and understand the functional implications of electrophysiological changes. We measured ERG CFF in RCS dystrophic (RCS-p+) and wild type (WT) rats at PN23, PN44, and PN64. ERG CFF data in RCS rats show significant early degeneration of the rods followed by cones. CFF was significantly lower …
Predictors Of Self-Reported Health Status In Occupationally And Environmentally Exposed Individuals, Christie Shelton
Predictors Of Self-Reported Health Status In Occupationally And Environmentally Exposed Individuals, Christie Shelton
All ETDs from UAB
Every year, over 3.5 billion pounds of industrial toxins and one to two billions pounds of environmental toxins are deliberately released into the environment. Although exposures have been shown to have an adverse effect on the health of the individuals, the effect of these exposures on the self-reported health status of individuals who have been environmentally and occupationally exposed to these toxins is still unclear. The purposes of this study were to: 1) identify the best subset of predictors of self-reported health status in current/former farmers and manufacturing workers from the set of age, sex, race, blood pressure, cholesterol measures, …
The Relationship Of Sexual Empowerment And Sexual Pressure To Condom Use Of Young Adult African American And Caucasian Women, Carrie Ann Long
The Relationship Of Sexual Empowerment And Sexual Pressure To Condom Use Of Young Adult African American And Caucasian Women, Carrie Ann Long
All ETDs from UAB
Introduction: HIV knowledge, high self-esteem, condom self-efficacy, positive attitudes toward condom use, and condom negotiation skills have been associated with decreased HIV risk behavior among women, but have not been examined within a framework of empowerment for sexual risk. Sexual pressure, inclusive of both coercive and noncoercive pressures to engage in unwanted or unprotected sex, has also not been studied in association with sexual empowerment as a framework or as a potential moderator between sexual empowerment and condom use among women of different racial groups. Study Purpose: 1) To explore the relationship between sexual empowerment and condom use; 2) to …
Impact Of Health Care Coverage And Other Socio-Demographic Variables On The Follow-Up Of Cervical Cancer Screening Among Colombian Women, Isabel Cristina Garces-Palacio
Impact Of Health Care Coverage And Other Socio-Demographic Variables On The Follow-Up Of Cervical Cancer Screening Among Colombian Women, Isabel Cristina Garces-Palacio
All ETDs from UAB
In Colombia, cervical cancer is the most common cancer among women with incidence (36.4/100,000) and mortality rates (18/100,000) much higher than those of the U.S. (7.7 and 2.3 respectively). About 70% of the Colombian population has health care coverage (HCC) through the subsidized regime (SR) which serves the poorest persons and the contributory regime (CR) which serves the working population. Our goal was to determine the role that HCC plays in cervical cancer screening follow-up among Colombian women. A population-based cross-sectional study of 24,717 women between the ages of 18 and 49, using the 2005 Demographic and Health Survey was …
Genome Copy Number Profiles Of African-American And European-American Early-Onset Breast Cancer, Tyesha Latrece Farmer
Genome Copy Number Profiles Of African-American And European-American Early-Onset Breast Cancer, Tyesha Latrece Farmer
All ETDs from UAB
Breast cancer is the second leading cause of cancer related death among women in the United States, surpassed only by lung cancer. It is estimated that over 200,000 women developed breast cancer and more than 40,000 died of the disease in 2008 alone. Although the overall incidence of breast cancer is lower in African-American women, the incidence of early-onset breast cancer is higher than that observed in European-American women. African-American women also have higher mortality rates due to this disease than those observed in their European-American counterparts. Breast cancer exhibits heterogeneity at the molecular, cellular, and clinical levels, and the …
The Protective Role Of Transglutaminase 2 In Ischemic Stroke, Anthony J. Filiano
The Protective Role Of Transglutaminase 2 In Ischemic Stroke, Anthony J. Filiano
All ETDs from UAB
Stroke is a leading cause of long term disabilities in the US. Currently, administration of thrombolytics is the only approved therapy. Due to the variability, small management time window, and lack of options for effective treatment, there is a clear need for new compounds to alleviate cell death post-stroke. Transglutaminase 2 (TG2) can decrease apoptotic signaling during stroke and lead to increased neuronal survival making it a potential target for therapeutic intervention. TG2, a multifunction enzyme that has both transamidase (TG) and GTPase activities, amongst others, has recently been shown to be upregulated in numerous neurodegenerative conditions, including stroke. In …
Maintaining Healthy Eating Behaviors With Women After A Weight Management Program: A Grounded Theory Approach, Christie Zunker
Maintaining Healthy Eating Behaviors With Women After A Weight Management Program: A Grounded Theory Approach, Christie Zunker
All ETDs from UAB
The purpose of this qualitative study was to explore the process of how women maintain their weight and continue healthy eating behaviors after completing a weight management program, which emphasized low-energy density foods. This is important since many women regain weight after participating in weight management programs. Theoretical sampling strategies guided participant recruitment. Inclusion criteria were: self-reported African American or Caucasian women aged 30 and older who lost > 5% of their body weight during their participation in the EatRight weight management program at least one year ago or longer. Height and weight was measured. Participants that remained > 5% below their …
Marginal Zone B-Cell Precursors As Cellular Agents For Type I Ifn Promoted Antigen Transport, John Hsien Wang
Marginal Zone B-Cell Precursors As Cellular Agents For Type I Ifn Promoted Antigen Transport, John Hsien Wang
All ETDs from UAB
Type I IFN is a known pro-inflammatory cytokine that is associated with the development of systemic lupus erythematosus (SLE). At the level of B-cell regulation, current literature primarily attributes the formation of autoantibodies at the post-germinal center stage when type I IFN is known to promote plasmablast differentiation. However, our findings here point to a type I IFN effect at the pre-germinal stage. Type I IFN promotes T-dependent antibody response, activation-induced cytidine deaminase (AID) expression, germinal center formation, all of which are processes before the onset of plasmablast differentiation. We have determined a subset of splenic transitional B-cells, that is …
Regulation Of Tissue Remodeling Through The Calreticulin Binding Domain Of Thrombospondin-1, Mariya Ts'ana Sweetwyne
Regulation Of Tissue Remodeling Through The Calreticulin Binding Domain Of Thrombospondin-1, Mariya Ts'ana Sweetwyne
All ETDs from UAB
Thrombospondin-1 (TSP1) is a multifunctional matricellular protein released by platelets in response to injury and secreted by cells under stress. TSP1 is cleaved into functional N- and C-terminal domain fragments, which have paradoxical actions with respect to angiogenesis, cell survival, and cell adhesion. Wound healing studies by others demonstrated that TSP1 knockout mice have delayed rates of wound closure, which was attributed to actions of the C-terminal domain. We wished to investigate the specific role of the N-terminal domain in tissue remodeling. Previously, we established that a sequence (aa 17-35) in the N-terminal domain of TSP1 induces focal adhesion disassembly, …
A Functional Analysis Of The Human Immunodeficiency Virus, Sushma Jyotika Bhakta
A Functional Analysis Of The Human Immunodeficiency Virus, Sushma Jyotika Bhakta
All ETDs from UAB
The retroviral life cycle is separated into two distinct phases of infection. In the first phase, viral enzymes and proteins allow the virus to establish infection. The virus usurps host machinery in the second stage to produce infectious virus. In both phases of the replication cycle, the envelope (Env) glycoprotein (gp) is a key component of infectivity. Env plays a pivotal role in viral entry, by mediating attachment and facilitating fusion of the viral and cellular membranes, and during assembly, where Env must be incorporated into budding virions in order to produce infectious virions. The Env cytoplasmic domain (CD) interacts …
Regulation Of Vh Replacement In Human Immature B Cells By B Cell Receptor (Bcr) - Mediated Signaling, Jing Liu
Regulation Of Vh Replacement In Human Immature B Cells By B Cell Receptor (Bcr) - Mediated Signaling, Jing Liu
All ETDs from UAB
VH replacement occurs through RAG-mediated secondary recombination to change unwanted IgH genes. In this dissertation, I focused on studying the molecular mechanism that regulates VH replacement in human immature B cells. In part I, our results show that VH replacement is regulated by B cell antigen receptor (BCR) mediated signaling. Using the human EU12 mHC+ cells as an experimental model system, crosslinking BCR with F(ab')2 anti-IgM antibodies results in BCR internalization, cell proliferation arrest, and induction of VH replacement. Pretreatment of human EU12 mHC+ cells with the protein tyrosine kinase inhibitor Genistein, Syk kinase inhibitors, and a Src kinase inhibitor …
Parenting Practices And Desire For A Child Among Mothers Living With Hiv, Natalie De La Cruz
Parenting Practices And Desire For A Child Among Mothers Living With Hiv, Natalie De La Cruz
All ETDs from UAB
One-quarter of adults living with HIV/AIDS in the US are women, most of whom are facing decisions regarding their reproductive future. Despite clear challenges and complexities facing HIV-positive women, most research suggests that they maintain strong desires and intentions for motherhood. This research explores the correlates of desire for another child, with a specific emphasis on examining the relationship between current parenting experiences and future childbearing desires, among a predominantly black sample of HIV-positive women (n=96) participating in the Making Our Mothers Stronger (MOMS) Project. Predictors of contraceptive use and consistency between contraceptive practices and fertility desires are also explored …
Involvement Of Reactive Oxygen Species In The Acute Development Of Insulin Resistance Following Trauma And Hemorrhage, Lidong Zhai
Involvement Of Reactive Oxygen Species In The Acute Development Of Insulin Resistance Following Trauma And Hemorrhage, Lidong Zhai
All ETDs from UAB
Hyperglycemia develops in the intensive care unit in many patients following injury, infection and critical illness. However, little is known about the mechanism of acute development of insulin resistance that causes this hyperglycemia, even though reducing or normalizing the elevated glucose levels has become a major therapeutic target in many ICUs. Using rodent models of injury, acute hepatic insulin resistance occurs within minutes and continues for at least several hours even following fluid resuscitation. We have previously reported that TNF-alpha; is necessary for the hepatic insulin resistance in the rat following resuscitation. However, whether TNF-alpha; plays a role in the …
Shunt Failure In Children With Hydrocephalus: Impact Of Sociodemographic Predictors On Time To Medical Evaluation For Shunt Failure And The Economic Burden Associated With Shunt Failure, Chevis Nacole Shannon
Shunt Failure In Children With Hydrocephalus: Impact Of Sociodemographic Predictors On Time To Medical Evaluation For Shunt Failure And The Economic Burden Associated With Shunt Failure, Chevis Nacole Shannon
All ETDs from UAB
Ventriculo-peritoneal shunts continue to be the standard surgical procedure for treating children diagnosed with hydrocephalus, regardless of etiology. The failure of these shunts can cause acute medical problems for the child requiring immediate medical care. It is known that hydrocephalus directly impacts a child's health status, educational abilities, developmental opportunities and emotional well being. An important gap in the current literature is the examination in a homogenous patient population of the impact of sociodemographic factors on the management of shunt failure and the economic burden on the family. The objective of this dissertation research study was to better understand shunt …
The Effects Of P-Glycoprotein Deficiency On Intestinal Integrity And Homeostasis, Elizabeth Marie Staley
The Effects Of P-Glycoprotein Deficiency On Intestinal Integrity And Homeostasis, Elizabeth Marie Staley
All ETDs from UAB
THE EFFECTS OF P-GLYCOPROTEIN DEFICIENCY ON INTESTINAL INTEGRITY AND HOMEOSTASIS ELIZABETH M. STALEY MICROBIOLOGY ABSTRACT P-glycoprotein (P-gp) is an ATP-binding transmembrane pump associated with substrate extrusion in cells of epithelial and hematopoietic lineage. Polymorphisms in multidrug resistance genes (MDR), which encode this protein, are associated with development of inflammatory bowel disease in patient subsets. Furthermore, FVB/N animals deficient in P-gp expression develop spontaneous colitis. Disease in FVB.mdr1a-/- animals is reported to be the result of P-gp deficiencies in intestinal epithelial cells. We developed a neonatal model of bone marrow reconstitution to accurately evaluate the contribution of P-gp deficiencies in either …