Medicine and Health Sciences Commons^™

Is Spironolactone An Effective Method For Reducing Lesion Count In Individuals With Acne Vulgaris?, Alana M. Waters

PCOM Physician Assistant Studies Student Scholarship

OBJECTIVE: The objective of this selective EBM review is to determine whether or not “Is spironolactone an effective method for reducing lesion count in individuals with acne vulgaris?”

STUDY DESIGN: A systematic review of three English language studies published after 2009 in peer-reviewed journals, including two randomized, controlled trials and one retrospective cohort study.

DATA SOURCES: Two randomized, controlled trials and one retrospective cohort study that evaluated spironolactone as a treatment for acne vulgaris were found using PubMed.

OUTCOMES MEASURED: Reductions in total lesion counts (TLC).

RESULTS: All three studies supported the efficacy of spironolactone in reducing lesion counts in …

Is Oral Isotretinoin More Effective Than Antibiotics In The Treatment Of Severe Acne In Adults?, Eric Thomas

PCOM Physician Assistant Studies Student Scholarship

Objective: The objective of this selective EBM review is to determine whether or not the use of oral isotretinoin is more effective than oral antibiotics in the treatment of severe acne.

Study Design: Review of all English language primary studies published after year 2000.

Data Sources: Three randomized control trials all found using PubMed. Outcomes Measured: Total number and percentage change in total acne lesions from baseline at various intervals.

Results: A randomized control trial (RCT) by Gollnick et al. (2001) found that oral isotretinoin was more effective than combination therapy involving minocycline in treating severe …

Is A Once Daily Topical Application Of Fixed-Dose Combination Gel Containing Adapalene 0.1%-Benzoyl Peroxide (Bpo) 2.5%(Adapalene-Bpo) Effective At Treating Mild To Moderate Acne?, Kelly A. Weitzel

PCOM Physician Assistant Studies Student Scholarship

OBJECTIVE: The objective of this selective EBM review is to determine whether or not a once daily topical application of fixed-dose combination gel containing adapalene 0.1%-benzoyl peroxide (BPO) 2.5% (adapalene-BPO) is effective at treating mild to moderate acne.

STUDY DESIGN: Three multi-center double blind randomized control studies published in the English language between 2007-2013.

STUDY SOURCES: Three peer-reviewed RCTS were found using Pubmed. These studies compared the same fixed-dose combination gel adapalene-BPO against placebo vehicles. Two studies also compared to additional groups receiving monotherapies.

OUTCOMES MEASURED: Outcomes measured were improvement of participant’s acne according to the Investigator’s Global Assessment of …

Is Glycolic Acid Safe And Effective In The Treatment Of Mild To Moderate Acne?, Brittany Stokes

PCOM Physician Assistant Studies Student Scholarship

OBJECTIVE: The objective of this selective EMB review is to determine whether or not the use of glycolic acid is effective in the treatment of inflammatory and non-inflammatory acne.

STUDY DESIGN: The review of three randomized, double-blind, controlled trials all published in English language between the years of 2008-2010.

DATA SOURCES: Three randomized, double-blind, controlled trails comparing glycolic acid to a visually matched placebo or pharmaceutical therapy in improvement of acne. All articles were found using PubMed and EBSCO.

OUTCOMES MEASURED: The improvement of inflammatory and non-inflammatory acne and tolerance/ safety of the intervention. Efficacy was …

Is A Low Glycemic Index Diet An Effective Treatment Regimen For Acne Vulgaris In Adolescents And Young Adults Ages 15-30?, Gina C. Tomkus

PCOM Physician Assistant Studies Student Scholarship

OBJECTIVE: The objective of this selective EBM review is to determine whether or not a low glycemic index (Low GI) diet is an effective treatment for acne vulgaris in adolescents and young adults ages 15-30.

STUDY DESIGN: Systematic review of two randomized, double blind, placebo controlled clinical trial and one parallel clinical trial published in peer-reviewed journals.

DATA SOURCES: Two randomized double blind clinical trials and one parallel clinical trial published in 2007, 2012, and 2010 respectively. The sources studying the use of a low glycemic index diet as a therapeutic intervention for acne vulgaris were obtained …

Is Dapsone Gel Safe And Effective For The Treatment Of Acne Vulgaris?, Amy Patel

PCOM Physician Assistant Studies Student Scholarship

OBJECTIVE: The objective of this selective EBM review is to determine whether or not dapsone gel is safe and effective for the treatment of acne vulgaris.

STUDY DESIGN: A review of three English language studies published in 2007. Includes two randomized, double-blind, controlled trials and one open label, noncomparative study. DATA SOURCES: Randomized, controlled trials comparing dapsone gel to vehicle gel control were found using PubMed and Cochrane database.

OUTCOMES MEASURED: Success on the Global Acne Assessment Score (GAAS) and reduction in acne lesion counts

RESULTS: The two randomized, controlled trials and the open-label noncomparative study …