Medicine and Health Sciences Commons^™

Malignant Hyperthermia, Jessica Joos

Nursing Student Class Projects (Formerly MSN)

Being a proficient anesthesia provider requires vigilantly monitoring for any complications that may arise during the anesthetic period. Malignant Hyperthermia (MH) is one such complication. Succinylcholine, a neuromuscular blocking agent, and volatile anesthetic gases can initiate an MH reaction. In MH, ryanodine receptors are stimulated to release excess calcium, which causes muscle hypermetabolism. This process causes the patient to develop highly elevated temperatures, hypoxia, hypercarbia, and muscle rigidity. Left untreated, MH can be fatal. Treatment requires discontinuation of the triggering agent, administering dantrolene, providing 100% oxygen, and managing complications such as acidosis, hyperkalemia, and arrhythmias. MH is a manageable complication …

Malignant Hyperthermia, Christina Bensley

Nursing Student Class Projects (Formerly MSN)

Malignant Hyperthermia

Christina Bensley

Department of Nursing, Otterbein University

NURS 6810: Advanced Pathophysiology for the Advanced Practice Nurse

Dr. Batross and Dr. Bhatnagar

August 5th, 2022

Abstract

Malignant Hyperthermia (MH) is a rare genetic mutation of the skeletal muscle that induces a hypermetabolic response when patients are exposed to volatile inhaled anesthetics or depolarizing neuromuscular blockers (Weant & Gregory, 2021). The first case of MH was identified in 1960, with an estimated mortality rate of 70-80% without appropriate treatment (Hopkins et al., 2021). Perioperative care providers must be able to identify triggering agents, recognize presenting signs and symptoms, and know …

Malignant Hyperthermia, Kathryn Hernandez

Nursing Student Class Projects (Formerly MSN)

Malignant hyperthermia (MH) is a condition in which the body goes into a hypermetabolic state affecting skeletal muscle in response to receiving inhaled anesthetics or the neuromuscular blocking agent, succinylcholine. MH is an autosomal dominant disorder that is most closely related to a defect in the ryanodine receptor. The defective receptor causes a rapid increase of intracellular calcium causing hyperthermia, tachycardia, tachypnea, hypercapnia, increased oxygen consumption, acidosis, hyperkalemia, muscle rigidity, and rhabdomyolysis. With the complexity of this disorder and its unique pathophysiological process it is crucial that all parts of the surgical team, especially anesthesia providers, understand how to treat …

Malignant Hyperthermia, Alexandra Mcguire

Nursing Student Class Projects (Formerly MSN)

Malignant Hyperthermia (MH) is a rare but life-threatening, genetic condition that can manifest when a patient is exposed to certain inhalation agents used in anesthesia as well as the depolarizing muscle relaxant succinylcholine (Rosenberg, Pollock, Schiemann, Bulger, & Stowell, 2015, p. 1). MH can develop during or after a surgical procedure and if left untreated, can cause major organ system damage and death (Seifert, Wahr, Pace, Cochrane, & Bagnola, 2014, p. 189). Creating awareness of this rare genetic condition allows for quicker interventions in reversing MH.

Melanoma, Christina Pfeifer

Nursing Student Class Projects (Formerly MSN)

The focus of this poster was to obtain information to enhance knowledge and understanding about melanoma. The areas of focus were the presentation of melanoma along with signs and symptoms, risk factors, the underlying pathophysiology, as well as, the significance of the pathology. Implications to nursing care were also reviewed and discussed. The poster shows graphics in relation to the mnemonic “ABCDE” in relation to signs and symptoms presented, as well as, a graphic displaying a genetic link of patients diagnosed with melanoma. The incidence of melanoma was found to be on the rise and therefore it is relevant and …

Malignant Hyperthermia, Brandon Kinnamon

Nursing Student Class Projects (Formerly MSN)

Common anesthetic agents can trigger a pathological response in patients resulting in intracellular calcium release and hyper-metabolism. This condition is known as Malignant Hyperthermia (MH). It is vital for anesthesia professionals and critical care nurses to recognize MH and act quickly to limit rapid shifts of electrolytes which can ultimately lead to death. As soon as cardinal signs of malignant hyperthermia are identified, the medication dantrolene should be administered along with intensive nursing care. Significant signs and symptoms, the pathophysiology of MH, and implications for nursing care are all examined in greater detail.

Prostate Cancer In African American Men, Chinwe Egwudo

Nursing Student Class Projects (Formerly MSN)

Prostate cancer, a malignancy with racial disparity, affects African American men more than Caucasians or any other race.

Malignant Hyperthermia, Garrett Erickson

Nursing Student Class Projects (Formerly MSN)

Malignant hyperthermia is known as a pharmacogenetic disorder which manifests itself in the skeletal muscle (Heytens, Forget, Scholtès, & Veyckemans, 2015). When a susceptible patient, who carries the autosomal dominant trait, is exposed to volatile anesthetics and/or the neuromuscular blocker succinylcholine, a detrimental response can occur. This response is a hypermetabolic state with hypercapnia, hemodynamic instability, rigidity, hyperthermia, and signs of rhabdomyolysis (Heytens et al., 2015). MH is a rare condition with incidences between 1/5,000 and 1/50,000 (Nagelhout and Plaus, 2014, p. 829), and often occurs during the induction of anesthesia but can also occur intraoperatively or one hour post …

Malignant Hyperthermia, Daniel Talbot

Nursing Student Class Projects (Formerly MSN)

Malignant Hyperthermia overview, signs and symptoms, pathophysiology, treatment, and implications for nursing care.

Malignant Hyperthermia, Taylor M. Morriss

Nursing Student Class Projects (Formerly MSN)

Complications related to the anesthetic process are multifaceted and abundant. As a future nurse anesthesia student, the underlying pathophysiology, diagnosis, and treatment of anesthesia-related complications are of particular interest. One such anesthesia-induced life-threatening metabolic process involves the hypermetabolism of skeletal muscle. This pharmacogenetic process, known as malignant hyperthermia (MH), has a variable incidence rate ranging from 1:10,000 to 1: 250,000 anesthetic cases. However, the prevalence of the genetic abnormalities may be as great as one in 400 individuals (Rosenberg, Pollock, Schiemann, Bulger, & Stowell, 2015, p. 1). “Malignant hyperthermia (MH) is a rare, but life-threatening, autosomal-dominant inherited disorder that may …