Medicine and Health Sciences Commons^™

Safety Of Lenadogene Nolparvovec Gene Therapy Over 5 Years In 189 Patients With Leber Hereditary Optic Neuropathy, Catherine Vignal-Clermont, Patrick Yu-Wai-Man, Nancy J. Newman, Valerio Carelli, Mark L. Moster, Valerie Biousse, Prem S. Subramanian, An-Guor Wang, Sean P. Donahue, Bart P. Leroy, Alfredo A. Sadun, Thomas Klopstock, Robert C. Sergott, Gema Rebolleda Fernandez, Bart K. Chwalisz, Rudrani Banik, Magali Taiel, Michel Roux, José-Alain Sahel

Wills Eye Hospital Papers

Purpose

To evaluate the safety profile of lenadogene nolparvovec (Lumevoq) in patients with Leber hereditary optic neuropathy.

Design

Pooled analysis of safety data from 5 clinical studies.

Methods

A total of 189 patients received single unilateral or bilateral intravitreal injections of a recombinant adeno-associated virus 2 (rAAV2/2) vector encoding the human wild-type ND4 gene. Adverse events (AEs) were collected throughout the studies, up to 5 years. Intraocular inflammation and increased intraocular pressure (IOP) were ocular AEs of special interest. Other assessments included ocular examinations, vector bio-dissemination, and systemic immune responses against rAAV2/2.

Results

Almost all patients (95.2%) received 9 × …

Physicians’ Considerations And Practice Recommendations Regarding The Use Of Sodium-Glucose Cotransporter-2 Inhibitors, Serge A. Jabbour, Nasrien E. Ibrahim, Christos P. Argyropoulos

Division of Endocrinology, Diabetes and Metabolic Diseases Faculty Papers

Sodium-glucose cotransporter-2 inhibitors (SGLT-2is) (canagliflozin, dapagliflozin, empagliflozin, and ertugliflozin), although initially developed as glucose-lowering drugs, provide significant beneficial effects on cardiorenal outcomes, including heart failure, regardless of type 2 diabetes status. Integration of SGLT-2is into clinical practice requires practical guidance for physicians about their use. To overcome physicians’ clinical inertia for SGLT-2i use, including addressing safety, potentially a barrier to their use, a roundtable discussion with physicians from three specialties (cardiology, endocrinology, and nephrology) was conducted. This review summarizes the physicians’ clinical experience and recommendations about SGLT-2i use across different patient populations, taking into consideration the beneficial effects of SGLT-2is …

Dataset Of Middle Cerebral Artery Blood Flow Stability In Response To High-Definition Transcranial Electrical Stimulation, Luiz H. Stefano, Diandra B. Favoretto, Diego C. Nascimento, Luan R.A. Santos, Marom Bikson, Joao P. Leite, Octavio M. Pontes-Neto, Dylan J. Edwards, Taiza G.S. Edwards

Moss-Magee Rehabilitation Papers

This supplementary dataset is supportive of the randomized sham-controlled, double-blind, crossover clinical trial investigating polarity- and intensity-dependent effects of high-definition transcranial electrical stimulation (HD-tDCS) applied over the right temporo-parietal junction on mean middle cerebral artery blood flow velocity (MCA-BFv) bilaterally. Data of eleven healthy right-handed adults (6 women, 5 men; mean age 31 ± 5.6 years old) were analyzed for MCA-BFv, assessed using transcranial doppler ultrasound on the stimulated and the contralateral hemisphere concomitantly, during and after 3 blocks of 2 min HD-tDCS at 1, 2, and 3 mA. Participants received three electrical stimulation conditions (anode center, cathode center, and …

Determining The Reliability Of Critical Controls In Construction Projects, Roberta Selleck, Maureen Hassall, Marcus Cattani

Research outputs 2022 to 2026

Across the global construction industry, fatalities continue to occur from high-risk activities, where the risk controls have been defined; however, these were unreliable. In the mining industry, Critical Control Risk Management has provided positive results in reducing major accidents, which raises the question, could the Critical Control approach reduce the fatality rate in the construction industry? This study analyzed 10 years of serious and fatal incident investigation reports from four international construction companies to (i) assess the reliability of their Critical Controls (CCs) and (ii) assess the factors that affect the reliability of CCs. The results show the reliability of …

Ums_Community Guidance_Students_Covid-19 Fall 2022 Vaccination Requirements, University Of Maine System

Community Guidance

Screenshot of webpage part of the "Together for Maine" University of Maine System providing information regarding vaccination requirements for the fall semester 2022.

Ums_Community Guidance_Employees_University Of Maine System Covid-19 Employee Vaccination Protocols, University Of Maine System

Community Guidance

Screenshot of webpage part of the "Together for Maine" University of Maine System guidance regarding vaccination protocols for employees.

Ums_Community Guidance_Students_Quarantine, Isolation, And Support Services, University Of Maine System

Community Guidance

Screenshot of webpage part of the "Together for Maine" University of Maine System with guidance on quarantine, isolation, and support services for students.

Ums_Community Guidance_Everyone_General Information Regarding Fall 2022 Programs, Visitor Access And Protocols, Visitor And Event Vaccination Requirements, Pandemic Protocols And Overall University Operations, University Of Maine System

Community Guidance

Screenshot of webpage part of the "Together for Maine" University of Maine System general information regarding fall 2022 programs, visitor access and protocols, visitor and event vaccination requirements, pandemic protocols and overall University operations.

Ums_Community Guidance_Everyone_Face Covering Requirements, University Of Maine System

Community Guidance

Screenshot of webpage part of the "Together for Maine" University of Maine System guidance regarding changes to face coverings requirements on UMS campuses.

Ums_Community Guidance_Everyone_General Information Regarding Summer 2022 Programs, Visitor Access And Protocols, Visitor And Event Vaccination Requirements, Pandemic Generally, And Overall University Operations, University Of Maine System

Community Guidance

Screenshot of webpage part of the "Together for Maine" University of Maine System containing general information regarding summer 2022 programs, visitor access and protocols, visitor and event vaccination requirements, pandemic generally, and overall University operations.

Ums_Community Guidance_Students_Summer 2022 Student Covid-19 Vaccination Requirement, University Of Maine System

Community Guidance

Screenshot of webpage part of the "Together for Maine" University of Maine System regarding summer 2022 student COVID-19 vaccination requirements.

Ums_Community Guidance_Employees_Quarantine And Isolation Updates: Stay 'Up-To-Date'; And, Have A Plan For Your Own Care, University Of Maine System

Community Guidance

Screenshot of webpage part of the "Together for Maine" University of Maine System guidance regarding quarantine and isolation requirements and information at the University of Maine System.

Surgeons And Ethical Challenges In Operating Room, Nazim Syed Muhammad, Syed Shahabuddin

Section of Urology

Ethics lie in the heart of professionalism. In surgery, it represents an essential element, with surgeons facing ethical challenges in their routine practice. The rapid expansion of surgical technology and innovation along with the use of resources and consideration of conflict of interest have brought up the need for the development of current surgical code of ethics. Operating room represents a stressful environment where patients' lives depend upon careful preparation, planning and execution. The progression of surgery within the operating room must be done in harmony and in line with the ethical principles of autonomy, beneficence, non-maleficence and justice. Discussion …

Ums_Community Guidance_Students_Updating Your Contact Information, University Of Maine System

Community Guidance

Screenshot of webpage part of the "Together for Maine" University of Maine System providing information regarding updating contact information.

An Informed Approach To The Development Of Primary Care Pediatric Firearm Safety Messages, Lindsay N Fuzzell, Sherry Dodd, Sisi Hu, Amanda Hinnant, Sungkyoung Lee, Glen Cameron, Jane M Garbutt

2020-Current year OA Pubs

BACKGROUND: Firearm ownership is prevalent in the US and many children spend time in areas where firearms are not stored safely. The AAP recommends firearm safety counseling at pediatric well-visits.

METHODS: We developed and tested six contextual messages to promote safe firearm storage based on: absence of harm, collective appeal to understanding child behavior, pediatrician's authority, evidence-based, fear appeal, and general safety considerations. One hundred four parents who keep firearms at home were recruited from Amazon Mechanical Turk Prime and viewed video messages and reported behavioral intentions and emotional reactions following each message.

RESULTS: All six contextual messages were perceived …

Ums_Community Guidance_Employees_Returning For The 2021-22 Academic Year, University Of Maine System

Community Guidance

Screenshot of webpage part of the "Together for Maine" University of Maine System guidance for continuing in-person operations for Spring 2022.

Public's Perceptions Of Early Mobility And Exercise In The Hospital And Intensive Care Unit: A Prospective Descriptive Survey, Amy Toonstra Pt, Dpt, Sydney Chelstrom Spt, Emily Ciesynski Spt, Mackenzie Dockendorf Spt, Brandon Hixson Spt

DPT Capstone Posters

Introduction

• 50% Amount of barriers to early mobility related to patient factors₁
• 25% Rate of physical therapy nontreatment or patient refusal₂
• Is lack of knowledge about benefits of activity a cause for these phenomena?

Objective

To evaluate public opinion on importance and safety of early mobility and exercise for individuals in the hospital and intensive care unit (ICU).

Participants

186 adults were recruited at the Minnesota State Fair in the University of Minnesota Driven to Discover Building to participate in the survey.

Methods

• Survey
• Adapted from previous validated survey₃
• 11 items
• 5 point Likert scale
• Established content …

Response And Rebuttal To "Comment On: Risk Factors For Workplace Encounters With Weapons By Hospital Employees" In Public Health In Practice; 3 (2022) 100256 By Chidinma Okani And Carmen Black, James D. Blando, Chalsie Paul, Mariana Szklo-Coxe

Community & Environmental Health Faculty Publications

No abstract provided.