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Full-Text Articles in Medicine and Health Sciences
Role Of T Cells In Cancer Immunotherapy: Opportunities And Challenges, Hossain Ahmed, Aar Rafi Mahmud, Mohd. Faijanur - Rob – Siddiquee, Asif Shahriar, Partha Biswas, Md. Ebrahim Khalil Shimul, Shahlaa Zernaz Ahmed, Tanzila Ismail Ema, Nova Rahman, Md. Arif Khan
Role Of T Cells In Cancer Immunotherapy: Opportunities And Challenges, Hossain Ahmed, Aar Rafi Mahmud, Mohd. Faijanur - Rob – Siddiquee, Asif Shahriar, Partha Biswas, Md. Ebrahim Khalil Shimul, Shahlaa Zernaz Ahmed, Tanzila Ismail Ema, Nova Rahman, Md. Arif Khan
School of Medicine Publications and Presentations
Immunotherapies boosting the immune system's ability to target cancer cells are promising for the treatment of various tumor types, yet clinical responses differ among patients and cancers. Recently, there has been increasing interest in novel cancer immunotherapy practices aimed at triggering T cell-mediated anti-tumor responses. Antigen-directed cytotoxicity mediated by T lymphocytes has become a central focal point in the battle against cancer utilizing the immune system. The molecular and cellular mechanisms involved in the actions of T lymphocytes have directed new therapeutic approaches in cancer immunotherapy, including checkpoint blockade, adoptive and chimeric antigen receptor (CAR) T cell therapy, and cancer …
Reprogramming Of Pancreatic Adenocarcinoma Immunosurveillance By A Microbial Probiotic Siderophore, Mehdi Chaib, Bilal B. Hafeez, Hassan Mandil, Deidre Daria, Ajeeth K. Pingili, Sonam Kumari, Mohammed Sikander, Vivek K. Kashyap, Emmanuel Anning, Manish Tripathi, Sheema Khan, Stephen Behrman, Murali M. Yallapu, Meena Jaggi, Subhash C. Chauhan
Reprogramming Of Pancreatic Adenocarcinoma Immunosurveillance By A Microbial Probiotic Siderophore, Mehdi Chaib, Bilal B. Hafeez, Hassan Mandil, Deidre Daria, Ajeeth K. Pingili, Sonam Kumari, Mohammed Sikander, Vivek K. Kashyap, Emmanuel Anning, Manish Tripathi, Sheema Khan, Stephen Behrman, Murali M. Yallapu, Meena Jaggi, Subhash C. Chauhan
School of Medicine Publications and Presentations
There is increasing evidence suggesting the role of microbiome alterations in relation to pancreatic adenocarcinoma and tumor immune functionality. However, molecular mechanisms of the interplay between microbiome signatures and/or their metabolites in pancreatic tumor immunosurveillance are not well understood. We have identified that a probiotic strain (Lactobacillus casei) derived siderophore (ferrichrome) efficiently reprograms tumor-associated macrophages (TAMs) and increases CD8 + T cell infiltration into tumors that paralleled a marked reduction in tumor burden in a syngeneic mouse model of pancreatic cancer. Interestingly, this altered immune response improved anti-PD-L1 therapy that suggests promise of a novel combination (ferrichrome and …
A Rare Case Of Penile Mucosal Melanoma, Safiya-Hana Belbina, Sofia Gereta, Mia Rose Schmolze, James Mclain Bradford, Christopher Yang, Aaron A. Laviana
A Rare Case Of Penile Mucosal Melanoma, Safiya-Hana Belbina, Sofia Gereta, Mia Rose Schmolze, James Mclain Bradford, Christopher Yang, Aaron A. Laviana
School of Medicine Publications and Presentations
No abstract provided.