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Full-Text Articles in Medicine and Health Sciences
Carum Carvi Modulates Acetaminophen-Induced Hepatotoxicity: Effects On Tnf-Α, Nf-Κb, And Caspases, Tahir Maqbool Mir, Muneeb U. Rehman, Mohammad Khalid Ashfaq, Wajhul Qamar
Carum Carvi Modulates Acetaminophen-Induced Hepatotoxicity: Effects On Tnf-Α, Nf-Κb, And Caspases, Tahir Maqbool Mir, Muneeb U. Rehman, Mohammad Khalid Ashfaq, Wajhul Qamar
Faculty and Student Publications
Carum carvi is a well-known herb traditionally used as a spice in Asian countries. Acetaminophen is a known marketed drug mainly used as an analgesic. It has been scientifically proven that consumption of acetaminophen (paracetamol) is associated with liver toxicity if taken in high doses without medical supervision. The present study evaluated the in vivo antioxidant and hepatoprotective efficacy of Carum carvi against acetaminophen-induced hepatotoxicity in Wistar rats. Our results demonstrate that Carum carvi, at doses (mg/kg) of 100 (D1) and 200 (D2), showed inhibitory properties for DNA-sugar damage, lipid peroxidation, DPPH scavenging, and increased reducing potential in a concentration-dependent …
Traditional Use, Phytochemical Profiles And Pharmacological Properties Of Artemisia Genus From Central Asia, Aliya Nurlybekova, Aidana Kudaibergen, Aizhan Kazymbetova, Magzhan Amangeldi
Traditional Use, Phytochemical Profiles And Pharmacological Properties Of Artemisia Genus From Central Asia, Aliya Nurlybekova, Aidana Kudaibergen, Aizhan Kazymbetova, Magzhan Amangeldi
Faculty and Student Publications
The flora of Kazakhstan is characterized by its wide variety of different types of medicinal plants, many of which can be used on an industrial scale. The Traditional Kazakh Medicine (TKM) was developed during centuries based on the six elements of ancient Kazakh theory, associating different fields such as pharmacology, anatomy, pathology, immunology and food nursing as well as disease prevention. The endemic Artemisia L. species are potential sources of unique and new natural products and new chemical structures, displaying diverse bioactivities and leading to the development of safe and effective phytomedicines against prevailing diseases in Kazakhstan and the Central …
Essential Oil Yield, Composition, And Bioactivity Of Sagebrush Species In The Bighorn Mountains, Valtcho D. Zheljazkov, Charles L. Cantrell, Ekaterina A. Jeliazkova, Tess Astatkie
Essential Oil Yield, Composition, And Bioactivity Of Sagebrush Species In The Bighorn Mountains, Valtcho D. Zheljazkov, Charles L. Cantrell, Ekaterina A. Jeliazkova, Tess Astatkie
Faculty and Student Publications
Sagebrush (Artemisia spp.) are dominant wild plants in large areas of the U.S., Canada and Mexico, and they include several species and subspecies. The aim was to determine if there are significant differences in essential oil (EO) yield, composition, and biological activity of sagebrush within the Bighorn Mountains, U.S. The EO yield in fresh herbage varied from 0.15 to 1.69% for all species, including 0.25–1.69% in A. tridentata var. vaseyana, 0.64–1.44% in A. tridentata var. tridentata, 1% in A. tridentata var. wyomingensis, 0.8–1.2% in A. longifolia, 0.8–1% in A. cana, and 0.16% in A. ludoviciana. There was significant variability in …