Medicine and Health Sciences Commons^™

Perspectives On Primary Blast Injury Of The Brain: Translational Insights Into Non-Inertial Low-Intensity Blast Injury, Heather R. Siedhoff, Shanyan Chen, Hailong Song, Jiankun Cui, Ibolja Cernak, David X. Cifu, Ralph G. Depalma, Zezong Gu

Physical Medicine and Rehabilitation Publications

Most traumatic brain injuries (TBIs) during military deployment or training are clinically “mild” and frequently caused by non-impact blast exposures. Experimental models were developed to reproduce the biological consequences of high-intensity blasts causing moderate to severe brain injuries. However, the pathophysiological mechanisms of low-intensity blast (LIB)-induced neurological deficits have been understudied. This review provides perspectives on primary blast-induced mild TBI models and discusses translational aspects of LIB exposures as defined by standardized physical parameters including overpressure, impulse, and shock wave velocity. Our mouse LIB-exposure model, which reproduces deployment-related scenarios of open-field blast (OFB), caused neurobehavioral changes, including reduced exploratory activities, …