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Antinociceptive Effects Of G-Protein Biased Mu Opioid Receptor Agonists In Male And Female Rats With Chemotherapy-Induced Neuropathy, Tilak Patel Md

Graduate Medical Education (GME) Resident and Fellow Research Day Posters

Aim: Mu-opioid receptor (MOR) agonists are often prescribed for the treatment of chemotherapy-induced neuropathy (CIN). Recent drug development strategies have focused on opioids with signaling profiles that “bias” activation of specific intracellular pathways (e.g., G-protein signaling) over others with the aim of increasing therapeutic selectivity. However, it is unknown if the variances in these signaling profiles at the MOR differentially modulate the antinociceptive effects of MOR agonists against neuropathic pain. In the present study, we tested a series of MOR agonists of varying G-protein signaling bias in a rat model of CIN. Methods: CIN was induced in male and female …